Interleukin-2 and 13-cis retinoic acid in the treatment of minimal residual disease: a phase II study.


:Interleukin-2 (IL-2) which has no cross-resistance with chemotherapy, has given responses in tumors resistant to chemotherapy, and shown to be more effective when tumor burden is low. 13-cis retinoic acid (RA) has immunomodulatory properties, potentially synergistic with IL-2. The objective of this pilot phase II study was to verify the immunomodulatory properties, activity and toxicity of outpatient immunotherapy with subcutaneous low dose IL-2 and oral RA, identified in a previous phase-I study, in patients with advanced solid cancer in whom a response or stable disease as a result of standard chemotherapy had been achieved. Eighty patients with advanced solid tumors after standard chemotherapy, were treated with IL-2: 1.8 x 106 IU and RA: 0.5 mg/kg for 5 days/week for 2 consecutive cycles of 3 weeks, with a 1-week rest, for up to 1 year. A total of 511 courses of IL-2/RA therapy were administered (median 6.4 per patient). Tumor markers, T4/T8 ratio and NK were monitored every 2 months. Response evaluation was carried out every 4 months. After a median follow-up time of 31 months there was a statistically significant improvement in the number of total lymphocytes, T4/T8 ratio and NK after IL-2 and RA therapy. Responses and disease stabilization were maintained for a median time of 19.3 months. Six patients were converted from partial to complete response, while 5 patients progressed. Median survival time was not reached yet. Grade 2 cutaneous toxicity and fever were observed in 29 and 13% of patients, respectively. These preliminary data show that after chemotherapy the administration of low-dose subcutaneous IL-2 and oral RA is feasible and has low toxicity. A sustained increase in the immunological parameters known to be prognostically relevant was observed and a clear benefit on tumor response from immunotherapy was obtained in 7.5% of patients.


Int J Oncol


Recchia F,De Filippis S,Rosselli M,Saggio G,Fumagalli L,Rea S



Has Abstract


2002-06-01 00:00:00












  • SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability.

    abstract::Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht U

    更新日期:2010-04-01 00:00:00

  • Oridonin induces apoptosis in oral squamous cell carcinoma probably through the generation of reactive oxygen species and the p38/JNK MAPK pathway.

    abstract::The anti-inflammatory effects of oridonin (Ordn) have been well established in previous studies. However, the apoptotic effects of Ordn on oral cancer cells have not yet been evaluated, at least to the best of our knowledge. The aim of this study was to examine the apoptotic activity of Ordn in oral squamous cell carc...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Oh HN,Seo JH,Lee MH,Yoon G,Cho SS,Liu K,Choi H,Oh KB,Cho YS,Kim H,Han AL,Chae JI,Shim JH

    更新日期:2018-05-01 00:00:00

  • Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fraction.

    abstract::Evidence indicates that a hypoxic micro-environment plays an essential role in the regulation of cancer stem cells (CSCs). However, whether hypoxia is able to regulate the stem-like biological properties of laryngeal cancer cells remains unknown. In this study, we investigated the influence of hypoxia on the stemness ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Wu CP,Du HD,Gong HL,Li DW,Tao L,Tian J,Zhou L

    更新日期:2014-05-01 00:00:00

  • Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model.

    abstract::Breast cancer remains the second most common disease worldwide. Radiotherapy, alone or in combination with chemotherapy, is widely used after surgery as a treatment for cancer with proven therapeutic efficacy manifested by reduced incidence of loco-regional and distant recurrences. However, clinical evidence indicates...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Calaf GM,Roy D

    更新日期:2017-11-01 00:00:00

  • Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility.

    abstract::Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Tameda M,Sugimoto K,Shiraki K,Yamamoto N,Okamoto R,Usui M,Ito M,Takei Y,Nobori T,Kojima T,Suzuki H,Uchida M,Uchida K

    更新日期:2014-08-01 00:00:00

  • Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.

    abstract::Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Kijima H,Yamazaki H,Nakamura M,Scanlon KJ,Osamura RY,Ueyama Y

    更新日期:2004-03-01 00:00:00

  • Anti-proliferative and anti-invasive properties of a purified fraction from Streptomyces sp. H7372.

    abstract::Secondary metabolites from actinomycetes especially the genus Streptomyces may be one of the most important sources for novel anticancer agents. A purified fraction from a novel actinomycete strain, Streptomyces sp. H7372, was elucidated in breast cancer cells. We have isolated three purified fractions from a novel st...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Yip WK,Cheenpracha S,Chang LC,Ho CC,Seow HF

    更新日期:2010-11-01 00:00:00

  • Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters.

    abstract::Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Kubo T,Sugita T,Shimose S,Nitta Y,Ikuta Y,Murakami T

    更新日期:2000-08-01 00:00:00

  • Inhibition of b16 melanoma metastasis by administration of g(m3)- or gg3- liposomes - blocking adhesion of melanoma-cells to endothelial-cells (antiadhesion therapy) via inhibition of g(m3)-gg3cer or g(m3)-laccer interaction.

    abstract::Tumor cell (TC) metastasis is initiated by selective adhesion of TCs to target structures such as basement membrane and endotheliaI cells (ECs), followed by transvascular migration of TCs. Variants of murine B16 melanoma having different metastatic potentials (in the order BL6 greater than or equal to F10>F1>WA4) have...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Otsuji E,Park Y,Tashiro K,Kojima N,Toyokuni T,Hakomori S

    更新日期:1995-02-01 00:00:00

  • p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location.

    abstract::The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Goh HS,Elnatan J,Low CH,Smith DR

    更新日期:1999-09-01 00:00:00

  • The effects of leukemia inhibitory factor (lif) on cell multiplication and locomotion in human teratocarcinoma cells.

    abstract::The human teratocarcinoma cell line (Tera 2) could be stimulated to a moderate increase in cell number in serum-free medium by addition of 5 ng leukemia inhibitory factor (LIF)/ml. However this effect was only observed in short term (24 h) cultures. By comparing cell numbers with thymidine incorporation data and propo...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Granerus M,Bierke P,Engstrom W

    更新日期:1994-12-01 00:00:00

  • O(2) extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues.

    abstract::The aim of this study was to assess pivotal factors determining the oxygenation status of malignant tumors, and, for comparison, of normal tissues. For this purpose, microvascular patterns, blood flow data, O2 consumption rates and O2 extractions were correlated to the median pO2 values of isografted rodent and xenogr...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Vaupel P,Thews O,Kelleher DK,Konerding MA

    更新日期:2003-04-01 00:00:00

  • Substrate stiffness affects epithelial-mesenchymal transition of cervical cancer cells through miR-106b and its target protein DAB2.

    abstract::The effects of different substrate stiffness were investigated on epithelial-mesenchymal transition (EMT) of cervical cancer cell lines and the role of miR-106b and its target protein DAB2 therein. Cervical cancer cell lines HeLa and SiHa were cultured on artificial substrates with different stiffness prepared using d...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Piao J,You K,Guo Y,Zhang Y,Li Z,Geng L

    更新日期:2017-06-01 00:00:00

  • HER2 analysis in breast cancer: reduced immunoreactivity in FISH non-informative cancer biopsies.

    abstract::Due to the central role in predicting response to herceptin and possibly also other anticancer drugs, accurate and reproducible detection of the HER2 status is important. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are the most commonly used methods for HER2 analysis. It is a disadvantage ...

    journal_title:International journal of oncology

    pub_type: 临床试验,杂志文章


    authors: Tapia C,Schraml P,Simon R,Al-Kuraya KS,Maurer R,Mirlacher M,Novotny H,Spichtin H,Mihatsch MJ,Sauter G

    更新日期:2004-12-01 00:00:00

  • miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells.

    abstract::MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Kim EA,Kim TG,Sung EG,Song IH,Kim JY,Doh KO,Lee TJ

    更新日期:2017-03-01 00:00:00

  • P53 expression in esophageal dysplasia - a possible biomarker for carcinogenesis of esophageal squamous-cell carcinoma.

    abstract::The tumor suppressor gene product p53 has been detected in a high percentage of esophageal squamous cell carcinoma. To evaluate the role of this protein in carcinogenesis, we examined the p53 overexpression both in esophageal dysplasia and in esophageal squamous cell carcinoma in the same patients. Using anti-p53 anti...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Maruyama K,Shiozaki H,Shimaya K,Inoue M,Iwazawa T,Matsui S,Mori T

    更新日期:1994-05-01 00:00:00

  • Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines.

    abstract::We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly dif...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Moriya S,Yanagihara K,Fujita H,Kuzumaki N

    更新日期:1994-12-01 00:00:00

  • Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo.

    abstract::Insulin-like growth factor-II (IGF-II)/IGF2R signaling plays a pivotal role in cell growth, migration and differentiation in many malignancies. An individual with high IGF-II expression levels has a high risk of developing cancer, but IGF2R is often considered to be a tumor suppressor. To date, little has been reporte...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Ou JM,Lian WS,Qiu MK,Dai YX,Dong Q,Shen J,Dong P,Wang XF,Liu YB,Quan ZW,Fei ZW

    更新日期:2014-09-01 00:00:00

  • Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells.

    abstract::The DNA topoisomerase I inhibitor beta-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of beta-lapachone on the growth of human prostate epithelial cells. Upon treatment with beta-lapachon...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Choi YH,Kim MJ,Lee SY,Lee YN,Chi GY,Eom HS,Kim ND,Choi BT

    更新日期:2002-12-01 00:00:00

  • Interferon γ suppresses dentin sialophosphoprotein in oral squamous cell carcinoma cells resulting in antitumor effects, via modulation of the endoplasmic reticulum response.

    abstract::The expression of proinflammatory cytokines in various malignant neoplasms is widely considered to represent the host immune response to tumor development. The role of interferon (IFN)γ in head and neck squamous cell carcinoma, and its association with endoplasmic reticulum (ER) stress pathways, remains a subject of o...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Gkouveris I,Nikitakis NG,Aseervatham J,Ogbureke KUE

    更新日期:2018-12-01 00:00:00

  • Cell cycle-specific patterns of ADP-ribosylation and the effect of ionizing radiation.

    abstract::The enzyme poly(ADP-ribose)polymerase (PARP) has been implicated in several cellular processes by the demonstration of ADP-ribosylation of proteins which play a role in cellular repair of DNA damage, response to ionizing radiation and apoptosis. In addition, ADP-ribosylation has been shown to play a role in cell cycle...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Ramsamooj P,Prasad S,Dritschilo A,Notario V

    更新日期:1996-04-01 00:00:00

  • Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro.

    abstract::Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Xiao S,Zhou Y,Yi W,Luo G,Jiang B,Tian Q,Li Y,Xue M

    更新日期:2015-04-01 00:00:00

  • Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.

    abstract::Quinazolinone derivatives are known to possess anticancer activities on cell metastasis and cell death in different human cancer cell lines. Here, we studied the anti-metastasis activity and the underlying mechanisms of the novel quinazoline derivative MJ-56 (6-pyrrolidinyl-2-(3-bromostyryl)quinazolin-4-one). MJ-56 in...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Chen HJ,Jiang YL,Lin CM,Tsai SC,Peng SF,Fushiya S,Hour MJ,Yang JS

    更新日期:2013-07-01 00:00:00

  • Endosialin: a novel malignant cell therapeutic target for neuroblastoma.

    abstract::Endosialin emerged recently as a potential therapeutic target for sarcoma. Since some sarcoma subtypes, such as Ewing's sarcoma, show characteristics of neuroendocrine differentiation, we wondered whether cancers with neuro-endocrine properties and/or neuroectodermal origin, such as neuroblastoma, small cell lung canc...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Rouleau C,Smale R,Sancho J,Fu YS,Kurtzberg L,Weber W,Kruger A,Jones C,Roth S,Bormann C,Dunham S,Krumbholz R,Curiel M,Wallar G,Mascarello J,Campos-Rivera J,Horten B,Schmid S,Miller G,Teicher BA

    更新日期:2011-10-01 00:00:00

  • The uptake of a monoclonal antibody (Po66) in lung tumour cell aggregates involves a phagocytose-like phenomenon.

    abstract::The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

    更新日期:1997-03-01 00:00:00

  • Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).

    abstract::In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to...

    journal_title:International journal of oncology

    pub_type: 杂志文章,评审


    authors: Gupta S

    更新日期:2003-01-01 00:00:00

  • Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer.

    abstract::Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

    更新日期:2006-01-01 00:00:00

  • Increased mdm2 expression and immunoreactivity in human pancreatic ductal adenocarcinoma.

    abstract::The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Ebert M,Yokoyama M,Kobrin M,Friess H,Buchler M,Korc M

    更新日期:1994-12-01 00:00:00

  • Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4.

    abstract::The transcription factor E2F4 plays a critical role in cell cycle progression of normal and cancerous intestinal epithelial cells. Contrary to other E2Fs, the coding region of the E2F4 gene contains a longer spacer segment of a CAG trinucleotide repeat sequence encoding 13 consecutive serine residues, which is highly ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Paquin MC,Leblanc C,Lemieux E,Bian B,Rivard N

    更新日期:2013-12-01 00:00:00

  • Expression of CD44 spliced variants with both exons v9 and v10 in primary N(-)M(-) breast carcinomas correlates with metastasis.

    abstract::We analyzed the representation of CD44 isoforms with both exons v9 and v10 among CD44 total amount and also examined correlation between their expression, clinical parameters and survival. We used a semi-quantitative RT-PCR reaction and a panel of 25 normal breast specimens, 10 mammary fibroadenomas, 8 cystic samples ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Guriec N,Gairard B,Marcellin L,Wilk A,Calderoli H,Renaud R,Bergerat J,Oberling F

    更新日期:1997-01-01 00:00:00