Increased mdm2 expression and immunoreactivity in human pancreatic ductal adenocarcinoma.

abstract：:Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...

journal_title：International journal of oncology

authors： Kondo R,Ishino K,Wada R,Takata H,Peng WX,Kudo M,Kure S,Kaneya Y,Taniai N,Yoshida H,Naito Z

更新日期：2019-04-01 00:00:00

abstract：:The purpose of the study was to determine whether the organ environment can influence the response of colon cancer cells to chemotherapy. The highly metastatic human colon cancer cell line KM12L4, previously selected for production of liver metastases in nude mice, was injected into the cecal wall and into the spleen ...

journal_title：International journal of oncology

authors： Wilmanns C,Fan D,Obrian C,Radinsky R,Bucana C,Tsan R,Fidler I

更新日期：1993-09-01 00:00:00

abstract：:Pancreatic neuroendocrine neoplasms (p-NENs) are slowly growing tumors with frequent liver metastasis. There is a variety of approaches to treat non-functional p-NENs with synchronous liver metastasis (LM) which complicates the determination of optimal treatment. Based on updated literature review, we discussed the tr...

journal_title：International journal of oncology

authors： Jin K,Xu J,Chen J,Chen M,Chen R,Chen Y,Chen Z,Cheng B,Chi Y,Feng ST,Fu D,Hou B,Huang D,Huang H,Huang Q,Li J,Li Y,Liang H,Lin R,Liu A,Liu J,Liu X,Lu M,Luo J,Mai G,Ni Q,Qiu M,Shao C,Shen B,Sheng W

更新日期：2016-11-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) is an important regulator of cell development and differentiation of various organs. Tumorigenesis and tumor progression are also strongly associated with changes of the fate of cells which are highly differentiated in healthy tissues. Therefore, we studied the role of BMP-7 in bre...

journal_title：International journal of oncology

authors： Schwalbe M,Sänger J,Eggers R,Naumann A,Schmidt A,Höffken K,Clement JH

更新日期：2003-07-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...

journal_title：International journal of oncology

authors： Wang H,Dai YY,Zhang WQ,Hsu PC,Yang YL,Wang YC,Chan G,Au A,Xu ZD,Jiang SJ,Wang W,Jablons DM,You L

更新日期：2017-07-01 00:00:00

abstract：:The p16INK4 gene, encoding a cyclin-dependent kinase inhibitor, is frequently methylated in colorectal cancer, and a side-specific methylation frequency was suggested. To clarify the frequency of real loss of tumor suppressor function dependent on anatomical localization, we investigated 43 primary colorectal carcinom...

journal_title：International journal of oncology

authors： Schneider-Stock R,Boltze C,Peters B,Höpfner T,Meyer F,Lippert H,Roessner A

更新日期：2003-10-01 00:00:00

abstract：:As epidemiological data suggest ultraviolet (UV) radiation to be the major environmental factor for the development of melanoma, we screened this malignancy for UV-specific C right curved arrow T and CC right curved arrow TT DNA mutations as described in squamous and basal cell carcinomas of the skin. Mitochondrial (m...

journal_title：International journal of oncology

authors： Deichmann M,Kahle B,Benner A,Thome M,Helmke B,Näher H

更新日期：2004-01-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...

journal_title：International journal of oncology

authors： Otsuki T,Fujimoto D,Hirono Y,Goi T,Yamaguchi A

更新日期：2014-12-01 00:00:00

abstract：:Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...

journal_title：International journal of oncology

authors： Fritz G,Issinger OG,Olsen BB

更新日期：2009-11-01 00:00:00

abstract：:Three major, fast developing lines of research are elucidating the biology of the mammary gland and its malignant transformation: phenotypical analyses of epithelial cells and mammary proliferative lesions, the identification, purification and characterization of mammary stem cells and breast cancer-initiating cells, ...

journal_title：International journal of oncology

authors： Birnbaum D,Bertucci F,Ginestier C,Tagett R,Jacquemier J,Charafe-Jauffret E

更新日期：2004-08-01 00:00:00

abstract：:Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that...

journal_title：International journal of oncology

authors： Poofery J,Sripanidkulchai B,Banjerdpongchai R

更新日期：2020-04-01 00:00:00

abstract：:Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. Transportation of LAPTM5 from Golgi to lysosome could be inhibit...

journal_title：International journal of oncology

authors： Chen L,Wang G,Luo Y,Wang Y,Xie C,Jiang W,Xiao Y,Qian G,Wang X

更新日期：2017-01-01 00:00:00

abstract：:An overview of the current mechanisms identified as associated with the expression of multidrug resistance is provided. The clinical relevance of multidrug resistance associated with the overexpression of the three major drug resistance-associated proteins namely, P-glycoprotein, MRP and/or LRP, is discussed. Alternat...

journal_title：International journal of oncology

authors： Hill B

更新日期：1996-08-01 00:00:00

abstract：:The homeobox transcription factor orthodenticle homeobox 2 (OTX2) plays a critical role in very early neurogenesis, but can become oncogenic when aberrantly expressed later in life. We previously discovered its novel oncogenic role in the malignant childhood brain tumor medulloblastoma and hypothesize an oncogenic rol...

journal_title：International journal of oncology

authors： Li J,Di C,Jing J,Di Q,Nakhla J,Adamson DC

更新日期：2015-11-01 00:00:00

abstract：:Mxi1 protein is a basic helix-loop-helix, leucine zipper (bHLHZIP) transcriptional factor, which dimerizes with the Max protein. This heterodimer binds a specific DNA sequence (E-box) and suppresses transcription of target genes. On the other hand, c-Myc protein is also a bHLHZIP protein that dimerizes with Max, binds...

journal_title：International journal of oncology

authors： Kawamata N,Sugimoto KJ,Sakajiri S,Oshimi K,Koeffler HP

更新日期：2005-05-01 00:00:00

abstract：:Primary liver cancer is globally the sixth most frequent cancer, and the second leading cause of cancer death and its incidence is increasing in many countries, thus, becoming serious threat to human health. Substantial research has focused on the treatment and prevention of liver cancer. However, the underlying molec...

journal_title：International journal of oncology

authors： Hu B,Sun M,Liu J,Hong G,Lin Q

更新日期：2016-04-01 00:00:00

abstract：:Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell l...

journal_title：International journal of oncology

authors： Habibie,Yokoyama S,Abdelhamed S,Awale S,Sakurai H,Hayakawa Y,Saiki I

更新日期：2014-08-01 00:00:00

abstract：:The aminoacyl-tRNA synthetase interacting multi-functional protein 1 (AIMP1) participates in a variety of cellular processes, including translation, cell proliferation, inflammation and wound healing. Previously, we showed that the N-terminal peptide of AIMP1 (6-46 aa) induced ERK phosphorylation. Liver fibrosis is ch...

journal_title：International journal of oncology

authors： Ahn J,Son MK,Jung KH,Kim K,Kim GJ,Lee SH,Hong SS,Park SG

更新日期：2016-02-01 00:00:00

abstract：:The lack of good molecular markers for diagnosis as well as treatment assessment has rendered the hepatocellular carcinoma (HCC) a major challenge in health care. In this study, woodchucks were used as an animal model for hepatitis virus-induced HCC, and gene expression studies were performed using a human oligonucleo...

journal_title：International journal of oncology

authors： Wang F,Anderson PW,Salem N,Kuang Y,Tennant BC,Lee Z

更新日期：2007-01-01 00:00:00

abstract：:The primary form of therapy for prostate cancer is androgen ablation resulting in apoptosis and expression of apoptotic genes (i.e. par-4). Prostate cancer cells that survive androgen ablation therapy express pro-survival genes (i.e. bcl-2) permitting these androgen independent (AI) cells to overcome apoptotic signals...

journal_title：International journal of oncology

authors： Fraizer G,Leahy R,Priyadarshini S,Graham K,Delacerda J,Diaz M

更新日期：2004-03-01 00:00:00

abstract：:A precise diagnosis of peritoneal dissemination is necessary to determine the appropriate treatment strategy for colorectal cancer. However, small peritoneal dissemination is difficult to diagnose. 5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism. The administration of 5-ALA to cancer pati...

journal_title：International journal of oncology

authors： Kondo Y,Murayama Y,Konishi H,Morimura R,Komatsu S,Shiozaki A,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Takahashi K,Inoue K,Nakajima M,Otsuji E

更新日期：2014-07-01 00:00:00

abstract：:Recent studies demonstrated an epigenetic inactivation of the runt-related transcription factor 3 (RUNX3) gene in human colon cancer. However, it remains unclear whether RUNX3 is tumor suppressive in colon cancer and, if so, the underlying molecular mechanisms of this activity are still unknown. In the present study, ...

journal_title：International journal of oncology

authors： Peng Z,Tang H,Wang X,Zhou C,Fan J,Wang L,Jia Z,Li Q,Le X,Wei D,Xie K

更新日期：2008-11-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00

abstract：:Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutation...

journal_title：International journal of oncology

authors： Furihata M,Shuin T,Takeuchi T,Sonobe H,Ohtsuki Y,Akiyama Y,Yuasa Y

更新日期：2000-03-01 00:00:00

abstract：:Transcriptional silencing of the DNA repair protein, O6-methylguanine-DNA methyltransferase (MGMT), occurs only in malignant or transformed cell lines, and such MGMT-deficient cells are hypersensitive to chemotherapeutic alkylating agents such as 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide. Previous...

journal_title：International journal of oncology

authors： Danam RP,Howell SR,Remack JS,Brent TP

更新日期：2001-06-01 00:00:00

abstract：:Of 108 Wistar/Ma rats perinatally injected with Snyder-Theilen feline sarcoma virus, 75 developed tumors within 60 days (group A), and 25 after more than 117 days (group B). Metastases were detected in 59.1% and 11.8% in group A and B respectively. Antibody to v-fes gene product was found to occur before tumor develop...

journal_title：International journal of oncology

authors： Lu S,Miyauchi M,Maruyama K

更新日期：1997-03-01 00:00:00

abstract：:The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...

journal_title：International journal of oncology

authors： Lohmeyer M,Mason S,Gullick W

更新日期：1997-04-01 00:00:00

abstract：:Abstract. The gestational trophoblastic diseases (GTD) are uncommon complications of pregnancy. The UK GTD registration scheme offers specialist facilities for screening and treatment. In Sheffield about 5% of all patients monitored require chemotherapy. The successful treatment - almost 100% cure - of these patients ...

journal_title：International journal of oncology

authors： Sheridan E,Hancock B,Smith S,Dorreen M,Neal F,Pennington G,Millar D

更新日期：1993-08-01 00:00:00

abstract：:Gastric carcinoma may occur sporadically or in association with hereditary diseases, such as Peutz-Jehgers syndrome (PJS). The PJS gene (named STK11 or LKB1) was mapped to 19p13.3 and recently cloned. Germ-line mutations of the gene have been detected in familial PJS patients and are predicted to predispose STK11 carr...

journal_title：International journal of oncology

authors： Park WS,Moon YW,Yang YM,Kim YS,Kim YD,Fuller BG,Vortmeyer AO,Fogt F,Lubensky IA,Zhuang Z

更新日期：1998-09-01 00:00:00