Modulation of Doxorubicin sensitivity and level of p-glycoprotein expression in human colon-carcinoma cells by ectopic and orthotopic environments in nude-mice.

abstract：:Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major rol...

journal_title：International journal of oncology

authors： Kawaguchi M,Banno K,Yanokura M,Kobayashi Y,Kishimi A,Ogawa S,Kisu I,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2009-11-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00

abstract：:WNT signaling pathway plays a key role in carcinogenesis and embryogenesis. We have cloned and characterized the human WNT5B. Overlapping WNT5B cDNAs, containing 1080-bp ORF, were isolated. WNT5B encoded a 359-amino-acid polypeptide with the N-terminal signal peptide, four N-linked glycosylation sites, and consensus a...

journal_title：International journal of oncology

authors： Saitoh T,Katoh M

更新日期：2001-08-01 00:00:00

abstract：:Cytokine production in squamous cell carcinoma (SCC) of the head and neck may directly influence the clinical behavior of this aggressive neoplasm since cytokines act as autocrine/paracrine growth factors, as well as immunomodulators. In the present study, the cytokine profiles of 16 SCCs of the head and neck and matc...

journal_title：International journal of oncology

authors： Sabourin C,Wang Q,Mallery S,Nicholson R,Gopalakrishnan R,Lang J,Schuller D,Stoner G

更新日期：1996-01-01 00:00:00

abstract：:The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in the progression of prostate cancer. In this study, we examined whether the TGF-β signaling pathway is associated...

journal_title：International journal of oncology

authors： Lee HR,Hwang KA,Choi KC

更新日期：2014-08-01 00:00:00

abstract：:The aim of this study was to demonstrate the potential of electrogene therapy with the bacterial purine nucleoside phosphorylase gene (ePNP), on pancreatic carcinoma (PC) large tumors. The in vivo electroporation (EP) conditions and efficacy were investigated on both subcutaneous xenografts of human PC cells in immuno...

journal_title：International journal of oncology

authors： Deharvengt S,Rejiba S,Wack S,Aprahamian M,Hajri A

更新日期：2007-06-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:Gliomas are malignant brain tumors thought to arise through multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cyclin D1 gene encodes a proto-oncogenic cell cycle regulator implicated in the pathogenesis of several types of cancer, including gliomas. Northe...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-09-01 00:00:00

abstract：:Liver cancer is the fourth leading cause of cancer‑related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2 (PIM2), has been shown to be overexpressed in liver cancer, ...

journal_title：International journal of oncology

authors： Kronschnabl P,Grünweller A,Hartmann RK,Aigner A,Weirauch U

更新日期：2020-02-01 00:00:00

abstract：:Metastasis is the main challenge of osteosarcoma treatment. Herein, we first reveal the oncogenic role of FAT10 in metastasis of osteosarcoma. FAT10 was upregulated in osteosarcoma, especially in metastatic osteosarcoma. High level of FAT10 was associated with poorer prognosis of osteosarcoma patients. Moreover, Trans...

journal_title：International journal of oncology

authors： Ma C,Zhang Z,Cui Y,Yuan H,Wang F

更新日期：2016-08-01 00:00:00

abstract：:The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy woul...

journal_title：International journal of oncology

authors： Pang Y,Liu J,Li X,Zhang Y,Zhang B,Zhang J,Du N,Xu C,Liang R,Ren H,Tang SC,Sun X

更新日期：2017-10-01 00:00:00

abstract：:5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity induced by 5-FU alon...

journal_title：International journal of oncology

authors： Lamberti M,Porto S,Zappavigna S,Stiuso P,Tirino V,Desiderio V,Mele L,Caraglia M

更新日期：2015-05-01 00:00:00

abstract：:The in situ formation of cytotoxic metabolites by an enzyme-catalyzed reaction is a recent approach in cancer therapy. The present results show that multidrug-resistant human colon adenocarcinoma cells (LoVo) are significantly more sensitive than corresponding wild-type cells to hydrogen peroxide and aldehydes, the pr...

journal_title：International journal of oncology

authors： Agostinelli E,Vedova LD,Belli F,Condello M,Arancia G,Seiler N

更新日期：2006-10-01 00:00:00

abstract：:Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...

journal_title：International journal of oncology

authors： Uchiyama T,Takahashi H,Endo H,Sugiyama M,Sakai E,Hosono K,Nagashima Y,Inayama Y,Wada K,Hippo Y,Nakajima A

更新日期：2011-10-01 00:00:00

abstract：:Release of DNA fragments into the culture supernatant of human promyelocytic cell line HL-60 was investigated. The released DNA has previously been shown to have a strong immunosuppressive effect on the proliferation of mitogen-stimulated human peripheral lymphocytes and some cancer cell lines. In this study, HL-60 ce...

journal_title：International journal of oncology

authors： Abolhassani M,Tillotson J,Chiao J

更新日期：1994-02-01 00:00:00

abstract：:Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous ad...

journal_title：International journal of oncology

authors： Tsukagoshi S,Saga Y,Suzuki N,Fujioka A,Nakagawa F,Fukushima M,Suzuki M

更新日期：2003-05-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. Genetic polymorphisms that decrease MTHFR activity result in an altered cancer risk depending on folic acid intake. In this study we examined the C677T an...

journal_title：International journal of oncology

authors： Singal R,Ferdinand L,Das PM,Reis IM,Schlesselman JJ

更新日期：2004-11-01 00:00:00

abstract：:The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of our knowledge, there are only...

journal_title：International journal of oncology

authors： Xu H,He Y,Ma J,Zhao Y,Liu Y,Sun L,Su J

更新日期：2020-09-01 00:00:00

abstract：:Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFkappaB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFkappaB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly in...

journal_title：International journal of oncology

authors： Huang C,Chen N,Ma WY,Dong Z

更新日期：1998-10-01 00:00:00

abstract：:Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can als...

journal_title：International journal of oncology

authors： Matsubara H,Maeda T,Gunji Y,Koide Y,Asano T,Ochiai T,Sakiyama S,Tagawa M

更新日期：2001-04-01 00:00:00

abstract：:The peptide hormone, GnRH has been hypothesized to play a direct antitumoral role in certain kinds of breast cancer. This direct effect is considered to function via high affinity membrane receptors to GnRH that have been demonstrated in tumors. However, no routine assay for GnRH receptors exist limiting further resea...

journal_title：International journal of oncology

authors： Reshkin S,Pezzetta A,Albarani V,Schittulli F,Paradiso A

更新日期：1995-08-01 00:00:00

abstract：:Mxi1 protein is a basic helix-loop-helix, leucine zipper (bHLHZIP) transcriptional factor, which dimerizes with the Max protein. This heterodimer binds a specific DNA sequence (E-box) and suppresses transcription of target genes. On the other hand, c-Myc protein is also a bHLHZIP protein that dimerizes with Max, binds...

journal_title：International journal of oncology

authors： Kawamata N,Sugimoto KJ,Sakajiri S,Oshimi K,Koeffler HP

更新日期：2005-05-01 00:00:00

abstract：:We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...

journal_title：International journal of oncology

authors： Hartmann K,Teckentrup R,Nixdorf D,Meuer S,Papa V,Heinrich U

更新日期：1993-06-01 00:00:00

abstract：:Liquid crystals are the state of matter existing between liquid and crystalline phases, and recently there has been increasing interest in their biological effects. Following our recently reported work, we investigated the cell suppressive effects of liquid crystal-related compounds (LCRCs), which are precursors of li...

journal_title：International journal of oncology

authors： Wakasaya T,Yoshino H,Fukushi Y,Yoshizawa A,Kashiwakura I

更新日期：2013-04-01 00:00:00

abstract：:Retroviral reverse transcriptase (RT) plays a definite role in retroviral life cycle and is essential for the process of retrotransposition. We investigated the RNA expression of endogenous reverse transcriptases (enRTs) in the NIH3T3 mouse genome using, as a probe, a mixture of RT-PCR generated reverse transcriptase ...

journal_title：International journal of oncology

authors： Tzavaras T,Eftaxia S,Tavoulari S,Hatzi P,Angelidis C

更新日期：2003-10-01 00:00:00

abstract：:We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...

journal_title：International journal of oncology

authors： Kolzau T,Deppert W

更新日期：1993-07-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:Rituximab resistance has become increasingly common in patients with diffuse large B cell lymphoma (DLBCL). However, the mechanisms involved remain unclear. In this study, we aimed to examine the effect of rituximab on interleukin (IL)-17A and to investigate the role of IL-17A in rituximab resistance and its prognosti...

journal_title：International journal of oncology

authors： Zhong W,Xu X,Zhu Z,Yang L,Du H,Xia Z,Yuan Z,Xiong H,Du Q,Wei Y,Li Q

更新日期：2018-05-01 00:00:00

abstract：:Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...

journal_title：International journal of oncology

authors： Michaelidou K,Tzovaras A,Missitzis I,Ardavanis A,Scorilas A

更新日期：2013-05-01 00:00:00

abstract：:The development of resistance to anticancer agents during treatment is a major obstacle in the chemotherapy of cancer. Cells expressing high levels of the P-glycoprotein exhibit a multidrug resistance phenotype. The P-glycoprotein is a membrane phosphoprotein which serves as a drug efflux pump to reduce intracellular ...

journal_title：International journal of oncology

authors： Srivastava R,Srivastava A,Chochung Y

更新日期：1996-11-01 00:00:00