Silencing FAT10 inhibits metastasis of osteosarcoma.

abstract：:Endothelial cells (ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11)...

journal_title：International journal of oncology

authors： Kim EH,Kim MS,Jeong YK,Cho I,You SH,Cho SH,Lee H,Jung WG,Kim HD,Kim J

更新日期：2015-10-01 00:00:00

abstract：:The effects of retinoic acid (RA) and its analogs, all-trans RA, 9-cis RA and 13-cis RA, were investigated in human breast cancer MCF-7 cells and immortalized breast epithelial cell line MCF-10A. RA inhibited the telomerase activity of MCF-7 cells in a wide range of concentrations. RA at 10 microM also inhibited the g...

journal_title：International journal of oncology

authors： Choi SH,Kang HK,Im EO,Kim YJ,Bae YT,Choi YH,Lee KH,Chung HY,Chang HK,Kim ND

更新日期：2000-11-01 00:00:00

abstract：:Allyl isothiocyanate (AITC), a member of the isothiocyanate (ITC) family found in a constituent of cruciferous vegetables, possesses anticancer activity and induces apoptosis in various types of human cancer cell lines. However, no available information showed antitumor effects in human breast adenocarcinoma cells. Th...

journal_title：International journal of oncology

authors： Tsai SC,Huang WW,Huang WC,Lu CC,Chiang JH,Peng SF,Chung JG,Lin YH,Hsu YM,Amagaya S,Yang JS

更新日期：2012-12-01 00:00:00

abstract：:Numerous dietary phytochemicals have shown anti-breast carcinogenic activities when tested in vitro; however, in most cases, the demonstrated efficacy of individual phytochemicals requires doses not readily achievable in vivo. Therefore, whether diets might exert translational promises and benefits in clinical setting...

journal_title：International journal of oncology

authors： Hsieh TC,Wu JM

更新日期：2008-10-01 00:00:00

abstract：:CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...

journal_title：International journal of oncology

authors： Sato K,Dang NH

更新日期：2003-03-01 00:00:00

abstract：:Despite attempts to use multiple drug combinations that include gemcitabine (GEM), there is very little evidence that these combination regimens are superior to the single use of this agent. We therefore investigated the suppressive effect of the combination of systemically administered GEM and locally administered in...

journal_title：International journal of oncology

authors： Ito Y,Aiura K,Ueda M,Kitajima M,Kitagawa Y

更新日期：2008-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) represent a class of small non-coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been described for several human malignancies. Herein, we show that miR-145 is down-regulated in human cancer cell line MCF-7 when compared...

journal_title：International journal of oncology

authors： Wang S,Bian C,Yang Z,Bo Y,Li J,Zeng L,Zhou H,Zhao RC

更新日期：2009-05-01 00:00:00

abstract：:The primary form of therapy for prostate cancer is androgen ablation resulting in apoptosis and expression of apoptotic genes (i.e. par-4). Prostate cancer cells that survive androgen ablation therapy express pro-survival genes (i.e. bcl-2) permitting these androgen independent (AI) cells to overcome apoptotic signals...

journal_title：International journal of oncology

authors： Fraizer G,Leahy R,Priyadarshini S,Graham K,Delacerda J,Diaz M

更新日期：2004-03-01 00:00:00

abstract：:Gene amplifications occurring in the q13 band of chromosome 11 are frequently observed in head and neck squamous cell carcinomas. In order to determine the relative frequency of amplification in 5 distinct 11q13 loci and their relation with clinical data, tumor DNAs from 31 patients - including 26 who had undergone ne...

journal_title：International journal of oncology

authors： Parise O,Janot F,Guerry R,Fortin A,Luboinski B,Tursz T,Schwaab G,Busson P

更新日期：1994-08-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is cytotoxic to the majority of cancer cells while sparing most normal cells. However, different prostate carcinoma cell lines respond with different sensitivities to TRAIL, urging us to disclose the mechanisms that determine TRAIL sensitivity in prostate...

journal_title：International journal of oncology

authors： Sonnemann J,Gekeler V,Sagrauske A,Müller C,Hofmann HP,Beck JF

更新日期：2004-10-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological cancer. We identified interleukin 11 (IL11) as a critical mediator of endometrial tumourigenesis and demonstrated that IL11 regulates chondroitin sulfate proteoglycan (CSPG4) in human placental trophoblasts. CSPG4 is a cell membrane protein overexpressed in numerous ...

journal_title：International journal of oncology

authors： Winship A,Van Sinderen M,Heffernan-Marks A,Dimitriadis E

更新日期：2017-03-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family and is highly expressed in several types of cancer cells and/or stromal tissue. Lumican expression in the cytoplasm in advanced colorectal cancer correlates with poor patient prognosis. The expression of lumican in stromal tissues is associated with a hig...

journal_title：International journal of oncology

authors： Matsuda Y,Yamamoto T,Kudo M,Kawahara K,Kawamoto M,Nakajima Y,Koizumi K,Nakazawa N,Ishiwata T,Naito Z

更新日期：2008-12-01 00:00:00

abstract：:Dissemination of single tumor cells to the bone marrow is a common event in cancer. The clinical significance of cytokeratin-positive cells detected in the bone marrow of cancer patients is still a matter of debate. In gastric cancer, overexpression of the receptor (uPAR or CD87) for the serine protease urokinase-type...

journal_title：International journal of oncology

authors： Noack F,Helmecke D,Rosenberg R,Thorban S,Nekarda H,Fink U,Lewald J,Stich M,Schutze K,Harbeck N,Magdolen V,Graeff H,Schmitt M

更新日期：1999-10-01 00:00:00

abstract：:Expressions of p53 protein and epidermal growth factor receptor (EGFR) were immunohistochemically investigated in 111 patients with papillary thyroid carcinomas (PTC) in order to evaluate their co-expression in relation to lymph node metastases (LNM), tumor size and clinicopathologic stage. In PTC, positive staining f...

journal_title：International journal of oncology

authors： Chen BK,Ohtsuki Y,Furihata M,Takeuchi T,Iwata J,Liang SB,Sonobe H

更新日期：1999-11-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumo...

journal_title：International journal of oncology

authors： Jögi A,Abel F,Sjöberg RM,Toftgård R,Zaphiropoulos PG,Påhlman S,Martinsson T,Axelson H

更新日期：2000-05-01 00:00:00

abstract：:The presence of arachidonate 12-lipoxygenase (12-LOX) potentiates prostate cancer (PCa) progression and therefore may be a good therapeutic target and/or a potential diagnostic predictor for PCa. In this study, we examined the expression of 12-LOX in PCa stem cells (PCa SCs) to test if it can serve as a unique marker ...

journal_title：International journal of oncology

authors： Yin B,Yang Y,Zhao Z,Zeng Y,Mooney SM,Li M,Xu X,Song Y,Wu B,Yang Z

更新日期：2011-04-01 00:00:00

abstract：:The expression of proinflammatory cytokines in various malignant neoplasms is widely considered to represent the host immune response to tumor development. The role of interferon (IFN)γ in head and neck squamous cell carcinoma, and its association with endoplasmic reticulum (ER) stress pathways, remains a subject of o...

journal_title：International journal of oncology

authors： Gkouveris I,Nikitakis NG,Aseervatham J,Ogbureke KUE

更新日期：2018-12-01 00:00:00

abstract：:Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...

journal_title：International journal of oncology

authors： Jung J,Jeong SY,Park SS,Shin SH,Ju EJ,Choi J,Park J,Lee JH,Kim I,Suh YA,Hwang JJ,Kuroda S,Lee JS,Song SY,Choi EK

更新日期：2015-03-01 00:00:00

abstract：:One of the major obstacles in curing prostate cancer is the development of drug resistance. It is not only imperative to discover the molecular basis of resistance but also to find therapeutic agents that can disrupt the resistant pathways. Tumor necrosis factor TNF-related apoptosis-inducing ligand TRAIL-like ligands...

journal_title：International journal of oncology

authors： Festuccia C,Gravina GL,D'Alessandro AM,Millimaggi D,Di Rocco C,Dolo V,Ricevuto E,Vicentini C,Bologna M

更新日期：2008-08-01 00:00:00

abstract：:In the present study, we analyzed the proliferation and cytotoxic activities of LAK cells and initial phase TILs by stimulation with IL-4. IL-4 obviously inhibited the DNA synthesis of LAK cells and initial phase TILs at the concentration of 250 pg/ml and 25 pg/ml, respectively. Furthermore, IL-4 (25 ng/ml for LAK cel...

journal_title：International journal of oncology

authors： Tsunoda T,Tanimura H,Yamaue H,Iwahashi M,Tani M,Tamai M,Noguchi K,Mizobata S,Arii K

更新日期：1995-11-01 00:00:00

abstract：:Expression of E-cadherin in esophageal carcinoma was studied immunohistochemically in 65 patients using an anti-human E-cadherin monoclonal antibody (HECD-1). In normal esophageal epithelium, E-cadherin was strongly expressed on cell-cell boundaries. On the contrary, a reduced E-cadherin expression (Rd-type) was frequ...

journal_title：International journal of oncology

authors： Miyata M,Shiozaki H,Iihara K,Shimaya K,Oka H,Kadowaki T,Inoue M,Tamura S,Takeichi M,Mori T

更新日期：1994-01-01 00:00:00

abstract：:Ganoderma lucidum (Curt.:Fr.) P. Karst, a medicinal fungus, has been widely used in Asian countries for centuries to prevent or treat a variety of diseases, including cancer. However, the mechanisms responsible for the effects of G. lucidum on cancer cells remain to be elucidated. We have previously shown that ethyl a...

journal_title：International journal of oncology

authors： Zaidman BZ,Wasser SP,Nevo E,Mahajna J

更新日期：2007-10-01 00:00:00

abstract：:Meningiomas are the most commonly occurring tumors of the central nervous system including the brain and spinal cord. Malignant meningiomas are highly aggressive and frequently recur after surgical resection of the tumor. Our previous studies have reported that urokinase plasminogen activator receptor (uPAR) and matri...

journal_title：International journal of oncology

authors： Tummalapalli P,Gondi CS,Dinh DH,Gujrati M,Rao JS

更新日期：2007-07-01 00:00:00

abstract：:In this communication, the roles of apoptosis-inducing factor (AIF) and Bcl-2 inhibitor of transcription (Bit1) in TAp63gamma-induced apoptosis were investigated in human esophageal squamous cancer EC9706 cells. Positive RNA and protein expressions of AIF and Bit1 in these cells were verified. However, no TAp63gamma c...

journal_title：International journal of oncology

authors： Fan T,Jiang G,Suo Z,Liu H,Xu P,Ji Z,Zhang L,Yang G

更新日期：2009-08-01 00:00:00

abstract：:We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...

journal_title：International journal of oncology

authors： Doucrasy S,Coll J,Barrois M,Joubel A,Prost S,Dozier C,Stehelin D,Riou G

更新日期：1993-05-01 00:00:00

abstract：:Mammalian sterile-20-like kinase 4 (MST4) has been implicated in cell proliferation and differentiation. In a previous study, we found MST4 to be an important candidate gene for metastatic hepatocellular carcinoma (HCC); however, the molecular mechanism of the promoting role of MST4 in HCC metastasis is poorly underst...

journal_title：International journal of oncology

authors： Lin ZH,Wang L,Zhang JB,Liu Y,Li XQ,Guo L,Zhang B,Zhu WW,Ye QH

更新日期：2014-08-01 00:00:00

abstract：:In the present study, a series of seven synthetic croma-kalim analogues were prepared and evaluated for cytotoxic effect on human cervical carcinoma HeLa cells using WST-8 assay. A preliminary screening of these cromakalim analogues showed that 1-[(3S,4R)-4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy- 2,2-dimethylchr...

journal_title：International journal of oncology

authors： Zhang X,Zhao J,Kang S,Yi M,You S,Shin DS,Kim DK

更新日期：2011-12-01 00:00:00

abstract：:Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymi...

journal_title：International journal of oncology

authors： Nishioka K,Fujimori Y,Hashimoto-Tamaoki T,Kai S,Qiu H,Kobayashi N,Tanaka N,Westerman KA,Leboulch P,Hara H

更新日期：2003-10-01 00:00:00