Interleukin-4 inhibits lak and initial phase til activity via interleukin-2 receptor.

abstract：:Colorectal cancer (CRC) treatment primarily relies on chemotherapy along with surgery, radiotherapy and, more recently, targeted therapy at the late stages. However, chemotherapeutic drugs have high cytotoxicity, and the similarity between the effects of these drugs on cancerous and healthy cells limits their wider us...

journal_title：International journal of oncology

authors： Zhang Z,Fang C,Wang Y,Zhang J,Yu J,Zhang Y,Wang X,Zhong J

更新日期：2018-11-01 00:00:00

abstract：:Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a s...

journal_title：International journal of oncology

authors： Choi YM,An S,Lee EM,Kim K,Choi SJ,Kim JS,Jang HH,An IS,Bae S

更新日期：2012-07-01 00:00:00

abstract：:CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...

journal_title：International journal of oncology

authors： Sato K,Dang NH

更新日期：2003-03-01 00:00:00

abstract：:The positron-emitting radiohalogens 18F, 75Br, 76Br, and 124I are reviewed regarding their relevance for positron emission tomography (PET) in oncology. Relevant production routes of these cyclotron-generated isotopes are given, followed by publications that deal with applications of these radiohalogens. This article ...

journal_title：International journal of oncology

authors： Glaser M,Luthra SK,Brady F

更新日期：2003-02-01 00:00:00

abstract：:Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...

journal_title：International journal of oncology

authors： Ciatto S,Cataliotti L,Pacini P,Distante V,Bianchi S,Simoncini R,Cardona G,Rontini M,Falli F,Elbetti C

更新日期：1993-08-01 00:00:00

abstract：:The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in the progression of prostate cancer. In this study, we examined whether the TGF-β signaling pathway is associated...

journal_title：International journal of oncology

authors： Lee HR,Hwang KA,Choi KC

更新日期：2014-08-01 00:00:00

abstract：:Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The re...

journal_title：International journal of oncology

authors： Zhang Y,Ying X,Han S,Wang J,Zhou X,Bai E,Zhang J,Zhu Q

更新日期：2013-01-01 00:00:00

abstract：:The development of carcinoma is associated with alterations in the expression of many cell adhesion molecules. Syndecan-1 is a cell surface proteoglycan that binds cells to the extracellular matrix and changes its expression following malignant transformation in some tumors. Our purpose was to examine the pattern of s...

journal_title：International journal of oncology

authors： Numa F,Hirabayashi K,Kawasaki K,Sakaguchi Y,Sugino N,Suehiro Y,Suminami Y,Hirakawa H,Umayahara K,Nawata S,Ogata H,Kato H

更新日期：2002-01-01 00:00:00

abstract：:The p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation. There are several reports that the reintroduction of the p16INK4A gene into p16(-) NSCLC cells results i...

journal_title：International journal of oncology

authors： Sumitomo K,Shimizu E,Shinohara A,Yokota J,Sone S

更新日期：1999-06-01 00:00:00

abstract：:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a ...

journal_title：International journal of oncology

authors： Park YK,Cho CH,Chi SG,Han CS,Ushigome S,Unni KK

更新日期：2001-10-01 00:00:00

abstract：:Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear matrix proteins during HMBA-induced differentiation of human...

journal_title：International journal of oncology

authors： Xu DH,Liu F,Li X,Chen XF,Jing GJ,Wu FY,Shi SL,Li QF

更新日期：2014-07-01 00:00:00

abstract：:177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...

journal_title：International journal of oncology

authors： Lundsten S,Spiegelberg D,Stenerlöw B,Nestor M

更新日期：2019-12-01 00:00:00

abstract：:We have recently demonstrated in a mouse renal adenocarcinoma tumor system that the antitumor effect of adriamycin (ADM) in combination with interleukin-2 (IL2) is superior to treatment with either ADM or IL2 alone. Based on this observation we postulated that modulation of host's immune competence by ADM and/or IL2 m...

journal_title：International journal of oncology

authors： Gautam S,Chikkala N,Ganapathi R

更新日期：1992-12-01 00:00:00

abstract：:We studied the expresssion of estrogen (ER), progesterone (PgR), and androgen receptors (AR) in hepatocellular carcinoma (HCC) and found expression in (7/36), 3.2% (1/31), 16.7% (4/24) of cases, respectively. The expression of ER did not correlate with histological grade, tumor size, or stage of disease. On the other ...

journal_title：International journal of oncology

authors： Ishizu H,Une Y,Gondo H,Kameda H,Uchino J

更新日期：1994-06-01 00:00:00

abstract：:Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...

journal_title：International journal of oncology

authors： Xiao S,Zhou Y,Yi W,Luo G,Jiang B,Tian Q,Li Y,Xue M

更新日期：2015-04-01 00:00:00

abstract：:The proteins of the rho gene family have been isolated from cytosolic as well as particulate fractions. The rho proteins have values of about 22KDa and have consensus amino acid sequences for GTP/GDP-binding and GTPase activities. We have localized the rho proteins in mammalian cells by using affinity-purified anti-pe...

journal_title：International journal of oncology

authors： Hauser C,Avraham S,Avraham H

更新日期：1993-12-01 00:00:00

abstract：:Although radiation therapy is a powerful anticancer modality, radiation- induced stress response and gene expression with adaptive resistance may severely compromise the effectiveness of radiation. The function of rotundic acid (RA) on inducing apoptosis in the human breast cancer cell line MCF-7 has been investigated...

journal_title：International journal of oncology

authors： Wang ZF,Sun WY,Yu DH,Zhao Y,Xu HM,He YF,Li HJ

更新日期：2018-11-01 00:00:00

abstract：:CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...

journal_title：International journal of oncology

authors： Jing F,Kim HJ,Kim CH,Kim YJ,Lee JH,Kim HR

更新日期：2015-04-01 00:00:00

abstract：:The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...

journal_title：International journal of oncology

authors： Lohmeyer M,Mason S,Gullick W

更新日期：1997-04-01 00:00:00

abstract：:Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/...

journal_title：International journal of oncology

authors： Mizutani Y,Katsuoka Y,Bonavida B

更新日期：2012-04-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers; however, the development of drugs to treat the condition has reached a plateau. Bortezomib (PS-341, Velcade®) is a proteasome inhibitor approved for the treatment of hematological malignancies, including multiple myeloma. A few trials of bortezomib, alone or i...

journal_title：International journal of oncology

authors： Hong YS,Hong SW,Kim SM,Jin DH,Shin JS,Yoon DH,Kim KP,Lee JL,Heo DS,Lee JS,Kim TW

更新日期：2012-07-01 00:00:00

abstract：:Gene amplification is an important phenomenon in the pathogenetics of malignancy. A method is defined which allows the determination of gene amplification from any sample from which RNA can be obtained, and requires no a priori knowledge of the cytogenetic or genomic state of the tumor. This method allows the determin...

journal_title：International journal of oncology

authors： Liang B

更新日期：1995-09-01 00:00:00

abstract：:A camptothecin (CPT) formulation that can be easily administered, is less toxic, and has greater antitumor effect is needed. In this study, a water-soluble CPT derivative was obtained by direct coupling of CPT to poly(L-glutamic acid) (PG) through the C20(S)-hydroxyl group. CPT was released from the resulting conjugat...

journal_title：International journal of oncology

authors： Zou Y,Wu QP,Tansey W,Chow D,Hung MC,Charnsangavej C,Wallace S,Li C

更新日期：2001-02-01 00:00:00

abstract：:Lipomas are the most common soft tissue tumors in adults. They often carry chromosome aberrations involving 12q13~15 leading to rearrangements of the HMGA2 gene in 12q14.3, with breakpoints occurring within or outside of the gene. Here, we present eleven lipomas and one osteochondrolipoma with a novel recurrent chromo...

journal_title：International journal of oncology

authors： Panagopoulos I,Gorunova L,Bjerkehagen B,Lobmaier I,Heim S

更新日期：2015-09-01 00:00:00

abstract：:Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. Transportation of LAPTM5 from Golgi to lysosome could be inhibit...

journal_title：International journal of oncology

authors： Chen L,Wang G,Luo Y,Wang Y,Xie C,Jiang W,Xiao Y,Qian G,Wang X

更新日期：2017-01-01 00:00:00

abstract：:Long noncoding RNA (lncRNA) MAF BZIP transcription factor G antisense RNA 1 (MAFG‑AS1) has been demonstrated to serve an important role in the progression of various types of cancer, whereas its role in breast cancer has not been fully elucidated. The present study aimed to explore the potential role and underlying me...

journal_title：International journal of oncology

authors： Jia H,Wu D,Zhang Z,Li S

更新日期：2020-11-20 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:The development of resistance to anticancer agents during treatment is a major obstacle in the chemotherapy of cancer. Cells expressing high levels of the P-glycoprotein exhibit a multidrug resistance phenotype. The P-glycoprotein is a membrane phosphoprotein which serves as a drug efflux pump to reduce intracellular ...

journal_title：International journal of oncology

authors： Srivastava R,Srivastava A,Chochung Y

更新日期：1996-11-01 00:00:00

abstract：:Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects...

journal_title：International journal of oncology

authors： Drago-Ferrante R,Santulli A,Di Fiore R,Giuliano M,Calvaruso G,Tesoriere G,Vento R

更新日期：2008-10-01 00:00:00