Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer.


:Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/DIABLO can be detected in the serum and then assess whether the circulating levels of Smac/DIABLO are of prognostic significance in patients with bladder cancer. The levels of Smac/DIABLO in the sera of 173 patients with bladder cancer and 36 normal donors were determined by using an enzyme-linked immunosorbent assay. The mean serum level of Smac/DIABLO in patients with bladder cancer was approximately 2-fold lower than that in normal donors. The mean level of serum Smac/DIABLO in patients with muscle-invasive bladder cancer was lower than that in patients with non-muscle invasive cancer. In addition, the mean serum Smac/DIABLO level in patients with T4 muscle-invasive bladder cancer was lower than that in patients with T2 and T3 cancers. The mean serum level of Smac/DIABLO in patients with Grade 3 bladder cancer was lower than that in patients with Grade 1 and Grade 2 cancers. Analysis by Kaplan-Meier revealed that patients with Ta and T1 non-muscle invasive bladder cancer with high level of serum Smac/DIABLO (more than mean value) had a longer post-operative tumor-free interval than those with low level (less than mean value) in the 3-year follow-up. Furthermore, patients with T2-T4 muscle-invasive bladder cancer with high serum Smac/DIABLO level (more than mean value) had a higher post-operative disease-free rate when compared with patients with low level (less than mean value) in the 5-year follow-up. The present study is the first to analyze circulating levels of Smac/DIABLO in the serum. The findings demonstrate that the mean serum level of Smac/DIABLO was downregulated in patients with bladder cancer compared to control healthy individuals, especially high grade muscle-invasive bladder cancer. Noteworthy, lower serum level of Smac/DIABLO predicted early recurrence in patients with bladder cancer. Overall, the findings suggest that measuring the levels of Smac/DIABLO in the serum may be considered a prognostic parameter in patients with bladder cancer. Furthermore, Smac/DIABLO may be a molecular therapeutic target in bladder cancer.


Int J Oncol


Mizutani Y,Katsuoka Y,Bonavida B




Has Abstract


2012-04-01 00:00:00












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    journal_title:International journal of oncology

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    authors: Hartomo TB,Van Huyen Pham T,Yamamoto N,Hirase S,Hasegawa D,Kosaka Y,Matsuo M,Hayakawa A,Takeshima Y,Iijima K,Nishio H,Nishimura N

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    journal_title:International journal of oncology

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    journal_title:International journal of oncology

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    pub_type: 杂志文章


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    journal_title:International journal of oncology

    pub_type: 杂志文章


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    更新日期:2006-07-01 00:00:00

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    journal_title:International journal of oncology

    pub_type: 杂志文章


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    更新日期:2011-04-01 00:00:00

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    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Zhang Z,Fang C,Wang Y,Zhang J,Yu J,Zhang Y,Wang X,Zhong J

    更新日期:2018-11-01 00:00:00

  • Sensitivity of fresh isolates of soft tissue sarcoma, osteosarcoma and giant cell tumour cells to Apo2L/TRAIL and doxorubicin.

    abstract::Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

    更新日期:2004-05-01 00:00:00