Syndecan-1 expression in cancer of the uterine cervix: association with lymph node metastasis.

abstract：:We assessed Stanniocalcin-1 (STC-1) mRNA expression in human normal tissues, various types of human cancer cell lines, and cancer tissues obtained during surgery. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay developed to detect STC-1 mRNA, the transcripts were detected in 20 out of 21 cancer ...

journal_title：International journal of oncology

authors： Fujiwara Y,Sugita Y,Nakamori S,Miyamoto A,Shiozaki K,Nagano H,Sakon M,Monden M

更新日期：2000-04-01 00:00:00

abstract：:As epidemiological data suggest ultraviolet (UV) radiation to be the major environmental factor for the development of melanoma, we screened this malignancy for UV-specific C right curved arrow T and CC right curved arrow TT DNA mutations as described in squamous and basal cell carcinomas of the skin. Mitochondrial (m...

journal_title：International journal of oncology

authors： Deichmann M,Kahle B,Benner A,Thome M,Helmke B,Näher H

更新日期：2004-01-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological cancer. We identified interleukin 11 (IL11) as a critical mediator of endometrial tumourigenesis and demonstrated that IL11 regulates chondroitin sulfate proteoglycan (CSPG4) in human placental trophoblasts. CSPG4 is a cell membrane protein overexpressed in numerous ...

journal_title：International journal of oncology

authors： Winship A,Van Sinderen M,Heffernan-Marks A,Dimitriadis E

更新日期：2017-03-01 00:00:00

abstract：:Multiple drug resistance is reported to be a major obstacle in treatment of osteosarcoma (OS). Research has demonstrated that small subsets of cells called cancer stem cells (CSCs) are responsible for multiple drug resistance. CSCs are potential targets for reversing chemoresistance. In the present study, we compared ...

journal_title：International journal of oncology

authors： Shang D,Wu J,Guo L,Xu Y,Liu L,Lu J

更新日期：2017-05-01 00:00:00

abstract：:Thirty patients who underwent hepatectomy for the treatment of hepatocellular carcinoma (HCC) were examined for expression of HLA class I antigens on HCC cells by flow cytometry. The expression was found significantly lower in cases of stage IV compared with those of stage I or stage II (p<0.05), and in cases of intra...

journal_title：International journal of oncology

authors： Nishibe M,Une Y,Kobayashi M,Kuramitsu Y,Hosokawa M,Uchino J

更新日期：1996-06-01 00:00:00

abstract：:The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody ...

journal_title：International journal of oncology

authors： Ishikawa T,Furihata M,Ohtsuki Y,Ono H,Inoue A,Ogoshi S

更新日期：1997-11-01 00:00:00

abstract：:The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...

journal_title：International journal of oncology

authors： Chen WJ,Xiong ZA,Zhang M,Yao CG,Zhao ZY,Hua YY,Zhou W

更新日期：2013-03-01 00:00:00

abstract：:On the basis of immunological results, it is not in doubt that the immune system is able to recognize and eliminate transformed cells. A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and ...

journal_title：International journal of oncology

authors： Scutti JAB

更新日期：2018-04-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:MicroRNAs (miRs) are short non-coding single stranded RNAs regulating the translation of target mRNAs in normal and cancer cells in which they are frequently dysregulated promoting tumor progression. Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC), identified by aldehyde-dehydrogenase express...

journal_title：International journal of oncology

authors： Sun Z,Hu W,Xu J,Kaufmann AM,Albers AE

更新日期：2015-10-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...

journal_title：International journal of oncology

authors： Shaughnessy M,Lamuraglia G,Klebanov N,Ji Z,Rajadurai A,Kumar R,Flaherty K,Tsao H

更新日期：2019-11-01 00:00:00

abstract：:It has been reported that XAF1 expression in gastric cancer is negatively correlated with p53. Our purpose was to clarify the regulatory mechanism of p53 on XAF1 expression. The effects of overexpressed wild-type and mutant p53 on XAF1 expression were evaluated. Binding capacity of core XAF1 promoter sequence to the r...

journal_title：International journal of oncology

authors： Zhang W,Guo Z,Jiang B,Niu L,Xia G,Wang X,Cheng T,Zhang Y,Wang J

更新日期：2010-04-01 00:00:00

abstract：:Peripheral blood was examined for the presence of tumor cells at multiple time points over a one-year period in 45 patients with a history of surgical resection of breast carcinoma. The number of circulating epithelial cells in 8 of 8 patients with clinically active disease concurred or preceded changes in the disease...

journal_title：International journal of oncology

authors： Terstappen LW,Rao C,Gross S,Weiss AJ

更新日期：2000-09-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated antigens (sTAA) of 66 kDa and 51 kDa could promote suppression of chemically-induced rat mammary tumorigenesis by the hormone-related anticancer drug tamoxifen and prevent the drug's toxic side-effects. Dimethylbenzanthracene (DMBA, 10 mg/rat, 3 administrations)...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2002-02-01 00:00:00

abstract：:Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a the...

journal_title：International journal of oncology

authors： Nitulescu GM,Margina D,Juzenas P,Peng Q,Olaru OT,Saloustros E,Fenga C,Spandidos DΑ,Libra M,Tsatsakis AM

更新日期：2016-03-01 00:00:00

abstract：:MCA serum levels were determined in 196 patients with benign breast disease (BD) and in 371 patients with breast cancer. MCA values were abnormal in 30.6% of the patients with BD. In breast cancer patients, significant increases were only found in metastatic disease (89.1%). MCA levels were not correlated with tumor s...

journal_title：International journal of oncology

authors： Donadeo A,Lorusso V,Micelli G,Quaranta M,Muncipinto A,Schittulli F

更新日期：1993-02-01 00:00:00

abstract：:Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this gene in a large series of primary tumors located outside the gastrointestinal tract which have been associated with loss ...

journal_title：International journal of oncology

authors： Verbeek W,Spirin K,Hatta Y,Miller C,Kawamata N,Takeuchi S,Koike M,Asou H,Simpson J,Koeffler H

更新日期：1997-02-01 00:00:00

abstract：:Polo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role in colorectal cancer (CRC) development remains unknown. The present study demonstrated that PLK4 protein expression was upregulated in CRC tissues compared with in normal tissues thr...

journal_title：International journal of oncology

authors： Liao Z,Zhang H,Fan P,Huang Q,Dong K,Qi Y,Song J,Chen L,Liang H,Chen X,Zhang Z,Zhang B

更新日期：2019-02-01 00:00:00

abstract：:The tumor suppressor protein p53 is one of the most important manipulators of the cell cycle. By interaction with targets such as WAF1/CIP1, mdm2 or GADD45 p53 functions as a negative or positive regulator of the cell cycle. After DNA damage p53 is implicated in growth arrest of cells in the G(1) phase of the cell cyc...

journal_title：International journal of oncology

authors： Gotz C,Montenarh M

更新日期：1995-05-01 00:00:00

abstract：:The mechanisms of invasion and metastasis are poorly understood. Our previous studies demonstrated that cancer cell invasion may result from reorganization of membrane molecules, thereby initiating signaling pathways. To increase our understanding on how cancer cells govern metastases we studied the established LNCaP ...

journal_title：International journal of oncology

authors： Van Slambrouck S,Jenkins AR,Romero AE,Steelant WF

更新日期：2009-06-01 00:00:00

abstract：:To investigate the relationships of the gross appearance to cancer depth and microinvasion in gallbladder cancer, thirty-three cancers were macroscopically subgrouped: papillary (n=8), nodular (n=6), papillo-invasive (n=1), nodulo-invasive (n=11), and invasive (n=7) type, respectively. Papillary type cancers were limi...

journal_title：International journal of oncology

authors： Namieno T,Takahashi M,Koito K,Sato N,Uchino J

更新日期：1996-02-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue tumors arising sporadically although more frequently in patients with Neurofibromatosis type 1. Prognosis remains dismal as chemo- and radiotherapy have not been shown to be successful. The heparin-binding growth factor, Midkine (MK), is impl...

journal_title：International journal of oncology

authors： Friedrich C,Holtkamp N,Cinatl J Jr,Sakuma S,Mautner VF,Wellman S,Michaelis M,Henze G,Kurtz A,Driever PH

更新日期：2005-11-01 00:00:00

abstract：:The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3, can induce differentiation in breast cancer cells; however, it is hypercalcemic in vivo. Therefore, development of non-calcemic analogs of vitamin D has received considerable attention. Recently, we synthesized an analog of vitamin D [1alpha(OH)D5] tha...

journal_title：International journal of oncology

authors： Mehta RR,Bratescu L,Graves JM,Green A,Mehta RG

更新日期：2000-01-01 00:00:00

abstract：:Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...

journal_title：International journal of oncology

authors： Thews O,Lambert C,Kelleher DK,Biesalski HK,Vaupel P,Frank J

更新日期：2005-09-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:Liposarcoma (LPS) is one of the most frequently reported type of soft‑tissue sarcoma (STS). Well‑differentiated (WD) LPS and dedifferentiated (DD) LPS are the two most common subtypes. Chemotherapy has been considered to be ineffective in LPS, and novel treatment agents are thus necessary. In this study, we reanalyzed...

journal_title：International journal of oncology

authors： Yen CC,Chen SC,Hung GY,Wu PK,Chua WY,Lin YC,Yen CH,Chen YC,Wang JY,Yang MH,Chao Y,Chang MC,Chen WM

更新日期：2019-10-01 00:00:00

abstract：:Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...

journal_title：International journal of oncology

authors： Baillargeon J,Rose DP

更新日期：2006-03-01 00:00:00

abstract：:Cytokines of the TGF beta family are thought to be involved in cellular growth control and are therefore likely candidates to regulate homeostasis of the prostate. We have analyzed immunohistochemically the expression of TGF-beta 3 in normal prostate (NP), benign prostate hyperplasia (BPH) and prostate cancer (PCa). I...

journal_title：International journal of oncology

authors： Djonov V,Andres A,Altermatt H,Merz V

更新日期：1997-12-01 00:00:00

abstract：:A murine B16 melanoma parental line (B16) and two clones either pigmented (B16P) or non-pigmented (B16NP) were cocultured as aggregates with mouse 3T3 fibroblasts. In vivo, these mixed aggregates developed more aggressive tumors in the mouse than corresponding pure aggregates. In vitro, the three pure cell lines secre...

journal_title：International journal of oncology

authors： Coucke P,Baramova E,Leprince P,Depauwgillet M,Foidart J,Bassleer R

更新日期：1994-11-01 00:00:00