Peripheral blood tumor cell load reflects the clinical activity of the disease in patients with carcinoma of the breast.

Abstract:

:Peripheral blood was examined for the presence of tumor cells at multiple time points over a one-year period in 45 patients with a history of surgical resection of breast carcinoma. The number of circulating epithelial cells in 8 of 8 patients with clinically active disease concurred or preceded changes in the disease activity. In 12 of 37 patients with no evidence of disease epithelial cells were found at least at one time point at a frequency larger than the control group. One patient had a recurrence of the breast cancer 4 weeks after circulating epithelial cells were detected in the blood.

journal_name

Int J Oncol

authors

Terstappen LW,Rao C,Gross S,Weiss AJ

doi

10.3892/ijo.17.3.573

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

573-8

issue

3

eissn

1019-6439

issn

1791-2423

journal_volume

17

pub_type

杂志文章
  • Inhibition of MMP-9 using a pyrrole-imidazole polyamide reduces cell invasion in renal cell carcinoma.

    abstract::We investigated the clinical significance of the expression levels of matrix metalloproteinase 9 (MMP-9) in renal cell carcinoma (RCC). In addition, we validated the efficacy of pyrrole imidazole polyamide (PIP) targeting MMP-9 on inhibiting proliferation and invasion of RCC. We evaluated the expression levels of MMP-...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2013.2073

    authors: Sato A,Nagase H,Obinata D,Fujiwara K,Fukuda N,Soma M,Yamaguchi K,Kawata N,Takahashi S

    更新日期:2013-11-01 00:00:00

  • Characterization and genetic analysis in the newly established human bile duct cancer cell lines.

    abstract::Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

    更新日期:2005-02-01 00:00:00

  • Immunomodulatory properties of antineoplastic drugs administered in conjunction with GM-CSF-secreting cancer cell vaccines.

    abstract::Cancer cells genetically modified to secrete immunoregulatory cytokines offer great promise for human cancer treatment as tumor vaccines. However, in preclinical animal studies, large established cancer burdens have appeared difficult to eradicate with such vaccines. For example, lethally-irradiated GM-CSF-secreting C...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.12.1.161

    authors: Nigam A,Yacavone RF,Zahurak ML,Johns CM,Pardoll DM,Piantadosi S,Levitsky HI,Nelson WG

    更新日期:1998-01-01 00:00:00

  • Prognostic-significance of p53 mutations in small non-cleaved cell lymphomas.

    abstract::We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which cont...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.4.3.567

    authors: Gutierrez M,Bhatia K,Diez B,Muriel F,Epelman S,Deandreas M,Huppi K,Magrath I

    更新日期:1994-03-01 00:00:00

  • High establishment efficiency of lymph node stromal cells which spontaneously produce multiple cytokines derived from adult T-cell leukemia/lymphoma patients.

    abstract::Stromal cells isolated from lymph nodes of adult T-cell leukemia/lymphoma (ATL) patients were cultured. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. The rate of human T lymphotropic virus type...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.9.4.619

    authors: Joh T,Yamada Y,Seto M,Nakamura S,Ohmoto Y,Kamihira S,Tomonaga M,Shiku H

    更新日期:1996-10-01 00:00:00

  • Reversible dissociation of a tumor-cell surface protease-inhibitor complex.

    abstract::Tumour cell surfaces possess a cell surface protease (GB), which can be recognised by a cytoplasmic inhibitor protein prepared from cultured tumour cells. This enzyme inhibitor complex has been shown to be reversibly dissociated by 10-(4)M sodium dodecyl sulphate. Sections of frozen tumour tissue were used to provide ...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.1.1.59

    authors: Steven F,Griffin M,Blakey D

    更新日期:1992-06-01 00:00:00

  • Inhibitory effect of bufalin combined with Hedgehog signaling pathway inhibitors on proliferation and invasion and metastasis of liver cancer cells.

    abstract::Hepatocellular carcinoma (HCC) is difficult to diagnose early, resulting in only 30% resection rate. HCC is a relatively chemo-resistant tumor, molecular targeted therapy can only benefit approximately 30% patients with liver cancer. Bufalin (Bu) is one of the topoisomerase II inhibitors, many studies have recently fo...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2016.3667

    authors: Sheng X,Sun X,Sun K,Sui H,Qin J,Li Q

    更新日期:2016-10-01 00:00:00

  • Identification of new genes differentially expressed in breast carcinoma cells treated with human chorionic gonadotropin.

    abstract::Human chorionic gonadotropin (hCG) inhibits the growth of human breast epithelial cells MCF-7. Differential display was utilized for analyzing RNA of hCG-treated MCF-7 cells in order to determine whether this effect was mediated by specific gene activation or repression. Three cDNA clones, 19, 29 and 44, were differen...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Srivastava P,Silva ID,Russo J,Mgbonyebi OP,Russo IH

    更新日期:1998-09-01 00:00:00

  • Expression and function of interleukin-8 in human hepatocellular carcinoma.

    abstract::Expression and functions of interleukin (IL)-8, a pro-inflammatory cytokine with angiogenesis action, was examined in 23 surgically resected hepatocellular carcinoma (HCC) specimens and 7 HCC cell lines. In all HCC tissues, IL-8 expression was confirmed with reverse-transcription polymerase chain reaction method and e...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.18.2.257

    authors: Akiba J,Yano H,Ogasawara S,Higaki K,Kojiro M

    更新日期:2001-02-01 00:00:00

  • Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene.

    abstract::Pleomorphic adenomas (PAs) of salivary glands are characterized by the mixed appearance of epithelial and mesenchymal-like components such as myxoid and chondroid tissues. Although various studies have examined PAs, thus far it is not clear how PAs make these multiple components. Thus, clarification of the histodiffer...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Kitagawa M,Ogawa I,Shima K,Hashimoto S,Kudo Y,Miyauchi M,Tahara H,Shimono M,Takata T

    更新日期:2007-08-01 00:00:00

  • Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases.

    abstract::CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2015.2844

    authors: Jing F,Kim HJ,Kim CH,Kim YJ,Lee JH,Kim HR

    更新日期:2015-04-01 00:00:00

  • Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significance.

    abstract::Multiple myeloma (MM) patients initially respond to conventional therapy, however, many develop resistance and have recurrences. We have reported in other tumors that the transcription factor Yin Yang 1 (YY1) is a resistant factor and, thus, we hypothesized that YY1 may be over-expressed in MM. Significantly, higher e...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2014.2511

    authors: Huerta-Yepez S,Liu H,Baritaki S,Del Lourdes Cebrera-Muñoz M,Rivera-Pazos C,Maldonado-Valenzuela A,Valencia-Hipolito A,Vega MI,Chen H,Berenson JR,Bonavida B

    更新日期:2014-09-01 00:00:00

  • Antitumor activity of human umbilical cord blood cells: A comparative analysis with peripheral blood and bone marrow cells.

    abstract::Although the hematopoietic reconstituting ability of human umbilical cord blood cells (UCBC) is well documented, their antitumor cytotoxic potential has not been well studied. Therefore, UCBC were compared to normal peripheral blood stem cells (PBSC) and bone marrow (BM) stem cell harvests for cytomorphology, antitumo...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.13.4.791

    authors: Joshi SS,Babushkina-Patz NN,Verbik DJ,Gross TG,Tarantolo SR,Kuszynski CA,Pirruccello SJ,Bishop MR,Kessinger A

    更新日期:1998-10-01 00:00:00

  • Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model.

    abstract::Breast cancer remains the second most common disease worldwide. Radiotherapy, alone or in combination with chemotherapy, is widely used after surgery as a treatment for cancer with proven therapeutic efficacy manifested by reduced incidence of loco-regional and distant recurrences. However, clinical evidence indicates...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2017.4125

    authors: Calaf GM,Roy D

    更新日期:2017-11-01 00:00:00

  • Long non‑coding RNA 00152 functions as a competing endogenous RNA to regulate NRP1 expression by sponging with miRNA‑206 in colorectal cancer.

    abstract::Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non‑coding RNAs (lncRNAs) play a critical role in CRC progression and metastasis; however, the bio...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2018.4451

    authors: Chen ZP,Wei JC,Wang Q,Yang P,Li WL,He F,Chen HC,Hu H,Zhong JB,Cao J

    更新日期:2018-09-01 00:00:00

  • Establishment and characterization of a novel cell line (cc‑006cpm8) of moderately/poorly differentiated colorectal adenocarcinoma derived from a primary tumor of a patient.

    abstract::In the present study, the cc‑006cpm8 novel colon cell line was established from a sample of right colorectal adenocarcinoma obtained from a woman with liver metastasis. It was possible to culture this cell line for ≥100 passages in vitro with vigorous growth. Morphologically, the cells grew as several layers with tigh...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2019.4806

    authors: Chu X,Xue Y,Huo X,Wei J,Chen Y,Han R,Chen H,Su X,Zhang H,Gong Y,Chen J

    更新日期:2019-07-01 00:00:00

  • Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells.

    abstract::We have initiated studies to enhance targeted delivery of an anticancer agent, curcumin, for prostate cancer treatment by incorporating this agent into the liposomes (nanodelivery vehicles primarily composed of phospholipids) coated with prostate membrane specific antigen specific antibodies. We prepared curcumin-load...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Thangapazham RL,Puri A,Tele S,Blumenthal R,Maheshwari RK

    更新日期:2008-05-01 00:00:00

  • Histone deacetylase 3 promotes pancreatic cancer cell proliferation, invasion and increases drug-resistance through histone modification of P27, P53 and Bax.

    abstract::Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2014.2568

    authors: Jiao F,Hu H,Yuan C,Jin Z,Guo Z,Wang L,Wang L

    更新日期:2014-10-01 00:00:00

  • Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21waf1/cip1 on the SP-B resistance or susceptibility of human leukemia cells.

    abstract::We previously showed that the B cell leukemia cell line NALM-6 had the highest susceptibility among a number of leukemia cell lines to spiruchostatin B (SP-B), a potent histone deacetylase (HDAC) inhibitor. We also showed that SP-B-induced cytotoxicity depended on induction of apopt...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2012.1507

    authors: Kanno S,Maeda N,Tomizawa A,Yomogida S,Katoh T,Ishikawa M

    更新日期:2012-09-01 00:00:00

  • Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors.

    abstract::Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

    更新日期:2007-02-01 00:00:00

  • Recapitulation of a normal cellular growth program in early invasive breast-cancer.

    abstract::With a view to identifying markers reflecting not the evidence of, but the potential for, neoplastic progression of the breast we have compared the normal invasive mammary epithelial cell growth seen at puberty with invasive and non-invasive carcinogenesis using the mouse as a model. We have analyzed cell proliferatio...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Djonov V,Altermatt H,Arnold A,Gerber H,Andres A

    更新日期:1995-08-01 00:00:00

  • Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1.

    abstract::The monocyte chemotactic protein 3 (MCP-3) belongs to the MCP subgroup of the CC chemokines and promotes chemotaxis of immune cells. MCP-1 is believed to play an important role in monocyte infiltration into tumor tissues; however, the relationship between tumor-infiltrating macrophage/microglia (TIM/M) and the express...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo_00000292

    authors: Okada M,Saio M,Kito Y,Ohe N,Yano H,Yoshimura S,Iwama T,Takami T

    更新日期:2009-06-01 00:00:00

  • miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.

    abstract::Chemotherapy is an important treatment option for gastric cancer (GC); however, chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR). In our previous studies, microRNA (miR)‑874 was demonstrated to serve an important role in tumour growth, apoptosis and angiogenesis. In the presen...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2018.4593

    authors: Huang H,Tang J,Zhang L,Bu Y,Zhang X

    更新日期:2018-12-01 00:00:00

  • CEOP-B/VIMB vs. promace-CytaBOM in the treatment of intermediate or high grade non-Hodgkin's lymphoma: A randomised multicenter study of Southern Italy Cooperative Group.

    abstract::From January 1992 to December 1995, 129 patients with previously untreated non-Hodgkin's lymphoma were randomised in a phase III multicenter trial to receive CEOP-B/VIMB or ProMACE-CytaBOM. Eligibility criteria included intermediate or high grade lymphoma (follicular large cell, diffuse small cleaved-cell, diffuse mix...

    journal_title:International journal of oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3892/ijo.16.1.149

    authors: Lorusso V,Palmieri G,Bianco AR,Abate G,Catalano G,De Vita F,Dammacco F,Lauta VM,Lucarelli G,Polimeno G,Mantovani G,D'Aprile M,Marzullo F,De Lena M

    更新日期:2000-01-01 00:00:00

  • High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism.

    abstract::Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the degradation of pyrimidines and pyrimidine base analogs including the anticancer drugs 5-fluorouracil (5-FU) and Xeloda. A decreased DPD enzyme activity has been described in cancer patients experiencing severe and life-threatening toxic...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:

    authors: Gross E,Seck K,Neubauer S,Mayr J,Hellebrand H,Ratanaphan A,Lutz V,Stockinger H,Kiechle M

    更新日期:2003-02-01 00:00:00

  • Deleterious MnSOD signals lead to abnormal breast cell proliferation by radiation and estrogen exposure.

    abstract::Manganese superoxide dismutase (MnSOD) seems to have a pivotal role in maintaining the normal phenotype by suppressing cell growth through blocking the entrance of quiescent cells into the cell cycle. MnSOD protein expression has been shown to be dysregulated in malignant cells. A well-established experimental breast ...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2011.978

    authors: Echiburú-Chau C,Roy D,Calaf GM

    更新日期:2011-06-01 00:00:00

  • Pathways regulating the expression of the immunomodulatory protein glycodelin in non‑small cell lung cancer.

    abstract::Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2018.4654

    authors: Weber R,Meister M,Muley T,Thomas M,Sültmann H,Warth A,Winter H,Herth FJF,Schneider MA

    更新日期:2019-02-01 00:00:00

  • Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells.

    abstract::Most cancer cells trigger thrombin generation (TG) to various extent. In the present study, we dissected the mechanisms responsible for the procoagulant activity of pancreatic adenocarcinoma cells (BXPC3), a highly thrombogenic cancer type, and breast cancer cells (MCF7), a less thombogenic tumor type. TG of normal pl...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2017.4172

    authors: Rousseau A,Larsen AK,Van Dreden P,Sabbah M,Elalamy I,Gerotziafas GT

    更新日期:2017-12-01 00:00:00

  • Implication of new figo surgical staging on patterns of failure and survival in endometrial carcinoma.

    abstract::Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.4.1.247

    authors: Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

    更新日期:1994-01-01 00:00:00

  • Modulation of carcinogen-induced polyoma DNA-replication by organoselenium and organosulfur chemopreventive agents.

    abstract::Both chemical and physical carcinogens are potent inducers of asynchronous replication of various DNA tumor viruses. Employing H3 cells that carry an integrated copy of polyoma virus we have evaluated potential effects of known chemopreventive agents on carcinogen-induced polyoma DNA replication. The ability of well e...

    journal_title:International journal of oncology

    pub_type: 杂志文章

    doi:10.3892/ijo.2.3.413

    authors: Foiles P,Miglietta L,Dolan L,Elbayoumy K,Ronai Z

    更新日期:1993-03-01 00:00:00