Mucin-like carcinoma-associated antigen (mca) serum levels in breast-cancer - a critical-appraisal.

abstract：:The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstrated that recombinant REIC/Dkk-3 protein induced the differentiation of h...

journal_title：International journal of oncology

authors： Watanabe M,Kashiwakura Y,Huang P,Ochiai K,Futami J,Li SA,Takaoka M,Nasu Y,Sakaguchi M,Huh NH,Kumon H

更新日期：2009-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...

journal_title：International journal of oncology

authors： Jing F,Kim HJ,Kim CH,Kim YJ,Lee JH,Kim HR

更新日期：2015-04-01 00:00:00

abstract：:Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

journal_title：International journal of oncology

authors： Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

更新日期：2007-02-01 00:00:00

abstract：:We examined the expression levels of P-glycoprotein (P-Gp)/the human multidrug resistance gene (MDR1) and in vivo chemosensitivity in the 7 osteosarcoma xenografts. Three of seven (43%) osteosarcoma xenografts expressed MDR1 by reverse transcriptase-polymerase chain reaction (RT-PCR). The OSS-516R xenograft selected w...

journal_title：International journal of oncology

authors： Suto R,Abe Y,Nakamura M,Ohnishi Y,Yoshimura M,Lee YH,Imanishi T,Yamazaki H,Kijima H,Tokunaga T,Oshika Y,Hiraoka N,Tamaoki N,Fukuda H,Ueyama Y

更新日期：1998-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) plays critical roles in cancer aggressiveness. We investigated the clinical and biological significance of neuropilin (NP)-1, a member of the VEGF receptor family, in colon carcinoma. We transfected NP-1-specific small interfering RNA (siRNA) into a human colon adenocarcinoma ...

journal_title：International journal of oncology

authors： Ochiumi T,Kitadai Y,Tanaka S,Akagi M,Yoshihara M,Chayama K

更新日期：2006-07-01 00:00:00

abstract：:Cancer progression has been associated with an increase in genomic instability indicated by inactivation of tumor suppressor genes and activation of oncogenes. Epidemiological and experimental evidence has implicated estrogens in the etiology of breast cancer. To study environmental organophosphorous pesticides is of ...

journal_title：International journal of oncology

authors： Calaf GM,Echiburu-Chau C,Roy D

更新日期：2009-11-01 00:00:00

abstract：:The anti-inflammatory effects of oridonin (Ordn) have been well established in previous studies. However, the apoptotic effects of Ordn on oral cancer cells have not yet been evaluated, at least to the best of our knowledge. The aim of this study was to examine the apoptotic activity of Ordn in oral squamous cell carc...

journal_title：International journal of oncology

authors： Oh HN,Seo JH,Lee MH,Yoon G,Cho SS,Liu K,Choi H,Oh KB,Cho YS,Kim H,Han AL,Chae JI,Shim JH

更新日期：2018-05-01 00:00:00

abstract：:In an attempt to isolate potential molecular targets for diagnosis, treatment and/or prevention of colorectal cancer (CRC), we have been analyzing expression profiles of clinical samples from CRC patients using genome-wide cDNA microarray. Among the genes up-regulated frequently in colorectal tumors, we here focused o...

journal_title：International journal of oncology

authors： Shimokawa T,Matsushima S,Tsunoda T,Tahara H,Nakamura Y,Furukawa Y

更新日期：2006-08-01 00:00:00

abstract：:Hypericin is used as a powerful naturally occurring photosensitizer in photodynamic therapy (PDT). Activated by visible light, it kills tumour cells and tissues via generation of reactive oxygen species (ROS). Depending on the protocol, apoptotic cell death can be achieved very effectively by hypericin-PDT. To analyze...

journal_title：International journal of oncology

authors： Sanovic R,Krammer B,Grumboeck S,Verwanger T

更新日期：2009-10-01 00:00:00

abstract：:Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. However, the effects of SAL on metastatic capacity of HT1080 human fibrosarcoma cells have not been elucidated. We investigated the effect of SAL on migration an...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2016-06-01 00:00:00

abstract：:The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

journal_title：International journal of oncology

authors： Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

更新日期：1997-03-01 00:00:00

abstract：:Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

journal_title：International journal of oncology

authors： Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

更新日期：2005-02-01 00:00:00

abstract：:Pemetrexed (PEM) is a novel, multitargeted, antifolate, antineoplastic agent for the treatment of non-small cell lung cancer and malignant pleural mesothelioma. Additional effects of nitric oxide (NO) donors on the chemosensitivity of cancers have been reported. However, the effects of an NO donor on PEM-induced cytot...

journal_title：International journal of oncology

authors： Nagai H,Yasuda H,Hatachi Y,Xue D,Sasaki T,Yamaya M,Sakamori Y,Togashi Y,Masago K,Ito I,Kim YH,Mio T,Mishima M

更新日期：2012-07-01 00:00:00

abstract：:A chromosomal break indicates a double-stranded DNA break of the chromatin fiber. Cytogenetic observations can enumerate chromosome breaks but cannot detect single-stranded DNA breaks (nicks). When a high frequency of chromosomal breaks occurs in a cell population, whether spontaneously occurred or mutagen induced, a ...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Liang J

更新日期：1993-06-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against several human cancer cell lines. In the present study, we investigated further possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured...

journal_title：International journal of oncology

authors： Park C,Jung JH,Kim ND,Choi YH

更新日期：2007-01-01 00:00:00

abstract：:Resistance may be classified as active (or competitive) (due to excess amount of a factor) vs passive (or non-competitive) (due to a deficiency of a factor). Passive resistance may be important in human solid tumors. In passive resistance, the dose-response curve may be shallow, or may flatten at a relatively low dose...

journal_title：International journal of oncology

authors： Stewart DJ,Goel R,Gertler SZ,Huan S,Tomiak EM,Yau J,Cripps C,Evans WK

更新日期：1999-10-01 00:00:00

abstract：:Peptide vaccine treatment has attracted attention in recent years as a new therapy option for chemotherapy‑resistant, advanced, unresectable cancer. The safety of peptide vaccination with HLA-A*2402-restricted URLC10-A24-177 and VEGFR1-A12-9 1084 epitope peptides (fixed 2-mg dose) was investigated in a phase I clinica...

journal_title：International journal of oncology

authors： Higashihara Y,Kato J,Nagahara A,Izumi K,Konishi M,Kodani T,Serizawa N,Osada T,Watanabe S

更新日期：2014-03-01 00:00:00

abstract：:The monocyte chemotactic protein 3 (MCP-3) belongs to the MCP subgroup of the CC chemokines and promotes chemotaxis of immune cells. MCP-1 is believed to play an important role in monocyte infiltration into tumor tissues; however, the relationship between tumor-infiltrating macrophage/microglia (TIM/M) and the express...

journal_title：International journal of oncology

authors： Okada M,Saio M,Kito Y,Ohe N,Yano H,Yoshimura S,Iwama T,Takami T

更新日期：2009-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found int...

journal_title：International journal of oncology

authors： Allegra A,Alonci A,Campo S,Penna G,Petrungaro A,Gerace D,Musolino C

更新日期：2012-12-01 00:00:00

abstract：:Highly aggressive murine B16 melanoma was engineered to secrete IFN-alpha constitutively. Cells expressing IFN-alpha were injected into syngeneic C57BL/6 mice and the mice were monitored for tumor development. Secretion of IFN-alpha by B16 melanoma cells completely abrogated their tumorigenicity in syngeneic mice. LFN...

journal_title：International journal of oncology

authors： Sarkar S,Flores I,Ron Y,Derosa C,Ozzello L,Pestka S

更新日期：1995-07-01 00:00:00

abstract：:The aim of the present study was to assess whether (-)-epigallocatechin 3-gallate (EGCG) via epigenetic modifications, regulates Raf kinase inhibitor protein (RKIP) expression and invasive metastatic activity in AsPC-1 pancreatic adenocarcinoma cells. Basal levels of RKIP were examined in various human pancreatic canc...

journal_title：International journal of oncology

authors： Kim SO,Kim MR

更新日期：2013-01-01 00:00:00

abstract：:The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy woul...

journal_title：International journal of oncology

authors： Pang Y,Liu J,Li X,Zhang Y,Zhang B,Zhang J,Du N,Xu C,Liang R,Ren H,Tang SC,Sun X

更新日期：2017-10-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target for anticancer drug design. However, few reports have described the constitutive activation of STAT3 in human sarcoma cells. In this study, we demonstrate that t...

journal_title：International journal of oncology

authors： Wei CC,Ball S,Lin L,Liu A,Fuchs JR,Li PK,Li C,Lin J

更新日期：2011-01-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：International journal of oncology

authors： Navolanic PM,McCubrey JA

更新日期：2005-11-01 00:00:00

abstract：:Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...

journal_title：International journal of oncology

authors： Jung KH,Ryu YL,Lee HS,Lee H,Son MK,Yan HH,Hong SW,Ryu JK,Hong S,Suh JK,Hong SS

更新日期：2013-06-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Lymph node metastasis of breast cancer is a clinical marker of poor prognosis. Yet, there exist no therapies targeting mechanisms of intravasation into lymphatics. Herein we report on an effect of the antidyslipidemic drug fenofibrate with vasoprotective activity, which attenuates breast cancer intravasation in vitro,...

journal_title：International journal of oncology

authors： Nguyen CH,Huttary N,Atanasov AG,Chatuphonprasert W,Brenner S,Fristiohady A,Hong J,Stadler S,Holzner S,Milovanovic D,Dirsch VM,Kopp B,Saiko P,Krenn L,Jäger W,Krupitza G

更新日期：2017-05-01 00:00:00

abstract：:We have examined six patients with multiple low grade, low stage superficial multifocal bladder tumors with surrounding tissues for loss of heterozygosity (LOH) and microsatellite instability at chromosome 3, totaling 76 samples. The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FH...

journal_title：International journal of oncology

authors： Louhelainen J,Wijkström H,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:Recombinant adenovirus-associated vector serotype 2 (rAAV2) is one of the most promising gene transfer vectors due to its advantage of causing non-pathogenic infection, low immunogenicity, and long-term gene expression in human clinical trials. Human interleukin 15 (hIL15) has been implicated in modulation of antitumo...

journal_title：International journal of oncology

authors： Yu YL,Wei CW,Chen YL,Chen MH,Yiang GT

更新日期：2010-02-01 00:00:00