Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin.

abstract：:We examined the expression levels of P-glycoprotein (P-Gp)/the human multidrug resistance gene (MDR1) and in vivo chemosensitivity in the 7 osteosarcoma xenografts. Three of seven (43%) osteosarcoma xenografts expressed MDR1 by reverse transcriptase-polymerase chain reaction (RT-PCR). The OSS-516R xenograft selected w...

journal_title：International journal of oncology

authors： Suto R,Abe Y,Nakamura M,Ohnishi Y,Yoshimura M,Lee YH,Imanishi T,Yamazaki H,Kijima H,Tokunaga T,Oshika Y,Hiraoka N,Tamaoki N,Fukuda H,Ueyama Y

更新日期：1998-02-01 00:00:00

abstract：:Identification of sensitive and specific biomarkers for early detection and prognosis of prostate cancer is essential for timely and appropriate treatment of the disease in individual patients. We identified an RNA transcript with sequence homology to TRPM8 (melastatin-related transient receptor potential member 8) th...

journal_title：International journal of oncology

authors： Bai VU,Murthy S,Chinnakannu K,Muhletaler F,Tejwani S,Barrack ER,Kim SH,Menon M,Veer Reddy GP

更新日期：2010-02-01 00:00:00

abstract：:The positron-emitting radiohalogens 18F, 75Br, 76Br, and 124I are reviewed regarding their relevance for positron emission tomography (PET) in oncology. Relevant production routes of these cyclotron-generated isotopes are given, followed by publications that deal with applications of these radiohalogens. This article ...

journal_title：International journal of oncology

authors： Glaser M,Luthra SK,Brady F

更新日期：2003-02-01 00:00:00

abstract：:MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...

journal_title：International journal of oncology

authors： Giannakouros P,Matte I,Rancourt C,Piché A

更新日期：2015-01-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) is an important regulator of cell development and differentiation of various organs. Tumorigenesis and tumor progression are also strongly associated with changes of the fate of cells which are highly differentiated in healthy tissues. Therefore, we studied the role of BMP-7 in bre...

journal_title：International journal of oncology

authors： Schwalbe M,Sänger J,Eggers R,Naumann A,Schmidt A,Höffken K,Clement JH

更新日期：2003-07-01 00:00:00

abstract：:Claudin 6 (CLDN6), a member of tight junction protein claudin (CLDN) family, inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. However, these molecular mechanisms of CLDN6-induced apoptosis remain largely elusive. We previously found that restoration of human CLDN6 gene expression was correlat...

journal_title：International journal of oncology

authors： Guo Y,Lin D,Zhang M,Zhang X,Li Y,Yang R,Lu Y,Jin X,Yang M,Wang M,Zhao S,Quan C

更新日期：2016-06-01 00:00:00

abstract：:The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in the progression of prostate cancer. In this study, we examined whether the TGF-β signaling pathway is associated...

journal_title：International journal of oncology

authors： Lee HR,Hwang KA,Choi KC

更新日期：2014-08-01 00:00:00

abstract：:The identification of cell surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene expression analysis. The data indicate that there a...

journal_title：International journal of oncology

authors： Teicher BA

更新日期：2007-02-01 00:00:00

abstract：:Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...

journal_title：International journal of oncology

authors： Tsai SY,Hsieh TC,Ardelt B,Darzynkiewicz Z,Wu JM

更新日期：2002-05-01 00:00:00

abstract：:In the present study, the precise mechanism of the enhancing action of histone deacetylase (HDAC) inhibitors on cisplatin (CDDP)-induced apoptosis was investigated using suberoylanilide hydroxamic acid (SAHA) in human oral squamous cell carcinoma cells (HSC-3). HDAC inhibitors are promising novel compounds for the tre...

journal_title：International journal of oncology

authors： Rikiishi H,Shinohara F,Sato T,Sato Y,Suzuki M,Echigo S

更新日期：2007-05-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:The modifying effects of dietary administration of capsaicin, which is the principal pungent capsicum fruit, and rotenone, which is a naturally occurring pesticide derived from Derris and Lonchorcarpus species, on azoxymethane (AOM)-induced colon tumorigenesis were investigated in male F344 rats. Gavage with capsaicin...

journal_title：International journal of oncology

authors： Yoshitani SI,Tanaka T,Kohno H,Takashima S

更新日期：2001-11-01 00:00:00

abstract：:We describe and discuss the findings by fluorescent in situ hybridization (FISH) for detection of non-random chromosomal gains, in a group of unusual fibrous lesions in children. Nuclear disaggregation was used to prepare slides from eight cases which were hybridized using alpha-satellite enumeration probes for chromo...

journal_title：International journal of oncology

authors： Flores-Stadler EM,Chou PM,Barquin N,Thangavelu M,Gonzalez-Crussi F

更新日期：2000-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training c...

journal_title：International journal of oncology

authors： Wang X,Liao X,Yu T,Gong Y,Zhang L,Huang J,Yang C,Han C,Yu L,Zhu G,Qin W,Liu Z,Zhou X,Liu J,Han Q,Peng T

更新日期：2019-10-01 00:00:00

abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

journal_title：International journal of oncology

authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

更新日期：2007-10-01 00:00:00

abstract：:The p16(INK4A) gene is frequently inactivated in nonsmall cell lung carcinoma (NSCLC) by either mutations, deletions or DNA methylations. To assess the biological significance of p16(INK4A) inactivation in the development of NSCLC, full-length p16(INK4A) cDNA was introduced into NSCLC cell lines, A549 and H322, in whi...

journal_title：International journal of oncology

authors： Adachi J,Kohno T,Baeg G,Akiyama T,Yokota J

更新日期：1997-01-01 00:00:00

abstract：:Paclitaxel (taxol) has been used for the treatment of various human tumors and is an exceedingly efficient chemotherapy agent against esophageal cancer. However, the precise molecular mechanisms of paclitaxel effects on human esophageal adenocarcinoma cells are not well understood. MTT assay and cell cycle analysis we...

journal_title：International journal of oncology

authors： Kim SJ,Chung MJ,Kim JS,Kim B,Park WH,Kim SH,Kim SZ,Lee JS,Kim SM

更新日期：2011-12-01 00:00:00

abstract：:Integrins are adhesion receptors involved in bidirectional signaling and are crucial for various cellular responses during normal homeostasis and pathological conditions, such as cancer progression and metastasis. In the present study, we demonstrated that blockage of β3 integrin-mediated cell- extracellular matrix in...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2016-03-01 00:00:00

abstract：:Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...

journal_title：International journal of oncology

authors： Markaverich B,Alejandro M

更新日期：1997-12-01 00:00:00

abstract：:Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to hepatocellular carcinoma (HCC) is currently unknown. The aim of this study was t...

journal_title：International journal of oncology

authors： Li L,Dong L,Qu X,Jin S,Lv X,Tan G

更新日期：2016-04-01 00:00:00

abstract：:Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E...

journal_title：International journal of oncology

authors： Vizirianakis IS,Chen YQ,Kantak SS,Tsiftsoglou AS,Kramer RH

更新日期：2002-07-01 00:00:00

abstract：:Currently, it is not entirely clear whether hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of COX-2 expression and epithelial-to-mesenchymal transition (EMT), and whether these events affect the prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolizati...

journal_title：International journal of oncology

authors： Huang M,Wang L,Chen J,Bai M,Zhou C,Liu S,Lin Q

更新日期：2016-05-01 00:00:00

abstract：:High consumption of soy products in some Asian countries has been linked to the low incidence of breast cancer in women. The chemopreventive effect of the soy isoflavone, genistein, has been observed through the suppression of cell proliferation, inhibition of angiogenesis and stimulation of apoptosis in breast carcin...

journal_title：International journal of oncology

authors： Valachovicova T,Slivova V,Bergman H,Shuherk J,Sliva D

更新日期：2004-11-01 00:00:00

abstract：:The p16INK4 gene, encoding a cyclin-dependent kinase inhibitor, is frequently methylated in colorectal cancer, and a side-specific methylation frequency was suggested. To clarify the frequency of real loss of tumor suppressor function dependent on anatomical localization, we investigated 43 primary colorectal carcinom...

journal_title：International journal of oncology

authors： Schneider-Stock R,Boltze C,Peters B,Höpfner T,Meyer F,Lippert H,Roessner A

更新日期：2003-10-01 00:00:00

abstract：:Resistance to first-line chemotherapeutic drugs such as gemcitabine contributes to the poor prognosis of patients with pancreatic cancer. MicroRNAs (miRNA) regulate chemoresistance in pancreatic cancer. By analyzing the miRNA sequencing dataset of pancreatic cancer from The Cancer Genome Atlas, it was demonstrated tha...

journal_title：International journal of oncology

authors： Sun D,Wang X,Sui G,Chen S,Yu M,Zhang P

更新日期：2018-05-01 00:00:00

abstract：:Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...

journal_title：International journal of oncology

authors： Isayeva T,Kumar S,Ponnazhagan S

更新日期：2004-08-01 00:00:00

abstract：:IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-...

journal_title：International journal of oncology

authors： Deforzh E,Vargas TR,Kropp J,Vandamme M,Pinna G,Polesskaya A

更新日期：2016-12-01 00:00:00

abstract：:Integrin alpha 6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin alpha 6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumor...

journal_title：International journal of oncology

authors： Mimori K,Mori M,Begum N,Tanaka S,Haraguchi M,Ueo H,Karimine N,Akiyoshi T,Barnard G

更新日期：1997-11-01 00:00:00

abstract：:We have previously demonstrated the multipotent nature of human umbilical cord blood stem cells (hUCB). In this study, we have attempted to show the use of hUCB in glioma therapy. We used hUCB enriched in CD44 and CD133 cells for our studies and observed that glioma cells co-cultured with hUCB undergo apoptosis. To pr...

journal_title：International journal of oncology

authors： Gondi CS,Gogineni VR,Chetty C,Dasari VR,Gorantla B,Gujrati M,Dinh DH,Rao JS

更新日期：2010-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of p53. Increasing evidence shows that miR-34a dysregulation may contribute to tumor development and progression in numerous cancers, includ...

journal_title：International journal of oncology

authors： Yang L,Song X,Zhu J,Li M,Ji Y,Wu F,Chen Y,Cui X,Hu J,Wang L,Cao Y,Wei Y,Zhang W,Li F

更新日期：2017-07-01 00:00:00