Abstract:
:Integrin alpha 6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin alpha 6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin alpha 6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Mimori K,Mori M,Begum N,Tanaka S,Haraguchi M,Ueo H,Karimine N,Akiyoshi T,Barnard Gdoi
10.3892/ijo.11.5.959subject
Has Abstractpub_date
1997-11-01 00:00:00pages
959-64issue
5eissn
1019-6439issn
1791-2423journal_volume
11pub_type
杂志文章abstract::Protein kinase C (PKC) designates a family of kinases that regulate many essential functions including cell growth and differentiation. The tight regulation of PKC activity is crucial for maintaining normal cellular proliferation and excessive activity leads to abnormal or uncontrolled cell growth. Recent reports indi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.2.327
更新日期:1999-02-01 00:00:00
abstract::Endothelial cells (ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11)...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3127
更新日期:2015-10-01 00:00:00
abstract::Lack of life-prolonging therapies has provided much of the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, the use of dietary supplements and botanical products has been showing a sustained increase in recent years, owing in part to some en...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutation...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The aim of the present study was to investigate the effects of lysyl oxidase‑like 2 (LOXL2) on the invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of renal cell carcinoma (RCC) cells through the steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway. RCC tissues and adjacen...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4726
更新日期:2019-05-01 00:00:00
abstract::Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.3869
更新日期:2017-03-01 00:00:00
abstract::A431 resistant variants to epoxomicin (EXM) were established, showing 4.0-6.7 times more resistance to EXM than parental A431P. Both variants demonstrated increased expression of the beta-subunit molecules of 26S proteasome with approximately 2.5 times increased activity. In variant cells, cyclin B and P34cdc2 were ov...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::Mutations in p53 are the most common genetic abnormality in cancers. Arsenic trioxide (ATO) is an effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia (APL) and is being tested in phase II studies in various types of cancers. We have shown that ATO is a potent inducer of apoptosis in mult...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::Gene amplification is an important phenomenon in the pathogenetics of malignancy. A method is defined which allows the determination of gene amplification from any sample from which RNA can be obtained, and requires no a priori knowledge of the cytogenetic or genomic state of the tumor. This method allows the determin...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can als...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.18.4.825
更新日期:2001-04-01 00:00:00
abstract::To compare the oncosuppressive activity of integrated and episomal adeno-associated virus (AAV), two Epstein-Barr virus (EBV) derived episomal form vectors, p205 and p220, were used to generate plasmids containing episomal AAV. HeLa cells transfected with p205, p220, and the plasmids with forward (pA205-1, pA220-1) an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.2.337
更新日期:1993-08-01 00:00:00
abstract::New aromatase inhibitors are an exciting treatment option for postmenopausal women with hormone sensitive breast cancer. They have been shown to reduce tumors in a significant number of patients, and exhibit definite antitumor activity at a relatively low daily dose, and are highly potent, highly selective, and well-t...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.17.5.1037
更新日期:2000-11-01 00:00:00
abstract::In the multistep progressive pathogenesis of human breast cancer, comedo ductal carcinoma in situ (DCIS) represents a preinvasive precursor lesion for therapy resistant invasive cancer. Human tissue derived cell culture models exhibiting molecular similarities to clinical DCIS facilitate an important preclinical mecha...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::The retinoic acid receptor (RAR) beta gene is located in a region on chromosome 3p, which is frequently deleted in renal cell carcinoma. Since retinoic acid (RA) can inhibit cell proliferation and tumor formation, loss of RAR beta might contribute to oncogenesis of the kidney. This prompted us to examine RAR beta expr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.2.391
更新日期:1995-02-01 00:00:00
abstract::Serum CASA, CEA, CYFRA 21-1, NSE, MSA, TPA, and TPS were determined in patients with lung cancer (LC), benign lung disease (BL), and healthy control (HC) donors. Using predefined cutpoints, the cytokeratin-related markers TPA, TPS, and CYFRA showed the highest sensitivity in non-small cell lung cancer (TPA 69%, TPS 63...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.5.1129
更新日期:1994-05-01 00:00:00
abstract::To investigate the usefulness of oral doxifluridine (5'-DFUR), an active intermediate metabolite of capecitabine (XELODA), in gastric cancer patients after curative resection, we conducted a phase III randomized controlled study to compare oral 5'-DFUR and oral 5-fluorouracil (5-FU). 485 gastric cancer patients with S...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3892/ijo.16.5.1021
更新日期:2000-05-01 00:00:00
abstract::Induction of differentiation represents a promising concept for chemotherapy of malignant gliomas, which are often refractory even to the combined treatment with surgery, irradiation and chemotherapy. Since anti-neoplastic alkylphosphocholines can induce differentiation of leukemic cell lines, the effects of the intra...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.4.673
更新日期:2001-10-01 00:00:00
abstract::Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases re...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4964
更新日期:2020-03-01 00:00:00
abstract::Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been frequently administered in colon cancer patients, low response rates to these single drug therapies were reported. It is therefore imperative to search for new targeted combination therapies t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000465
更新日期:2009-12-01 00:00:00
abstract::MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of p53. Increasing evidence shows that miR-34a dysregulation may contribute to tumor development and progression in numerous cancers, includ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4015
更新日期:2017-07-01 00:00:00
abstract::Conventional cancer treatments are not adequate for the majority of most patients stricken with squamous cell carcinomas of the head and neck (SCCHN). Conditionally replicating adenoviruses (CRAds) represent a promising new modality for treating of neoplastic diseases, including SCCHN. Specifically, CRAd agents infect...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2707
更新日期:2015-01-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is characterized by extensive angiogenesis that is mostly orchestrated by the hypoxia inducible factor HIF-1. Deregulation of HIF-1 is believed to contribute to cancer initiation and progression. However, instances have been described in which loss of HIF-1 leads to more aggressive tumors...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000554
更新日期:2010-04-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found int...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2012.1647
更新日期:2012-12-01 00:00:00
abstract::Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. F...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.1.4.403
更新日期:1992-09-01 00:00:00
abstract::Identification of sensitive and specific biomarkers for early detection and prognosis of prostate cancer is essential for timely and appropriate treatment of the disease in individual patients. We identified an RNA transcript with sequence homology to TRPM8 (melastatin-related transient receptor potential member 8) th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract::Metastatic disease commonly occurs in the spine and incidence is likely to increase secondary to improved survival rates in many cancer patients. Despite published research on instability in patients with metastatic disease of the thoracolumbar spine, controversy exists regarding risk factors for instability and indic...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::We have previously isolated a drug-resistant, [PC3(R)], variant of human prostate PC3 cell line, which showed significant resistance (>10-fold) to adriamycin. No known mechanisms of drug resistance were found; however, resistant cells expressed more bcl2, c-myc, and ms oncogenes compared to the sensitive cells. In thi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.4.819
更新日期:1997-10-01 00:00:00
abstract::Interleukin-2 (IL-2) which has no cross-resistance with chemotherapy, has given responses in tumors resistant to chemotherapy, and shown to be more effective when tumor burden is low. 13-cis retinoic acid (RA) has immunomodulatory properties, potentially synergistic with IL-2. The objective of this pilot phase II stud...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-06-01 00:00:00