Abstract:
:We describe and discuss the findings by fluorescent in situ hybridization (FISH) for detection of non-random chromosomal gains, in a group of unusual fibrous lesions in children. Nuclear disaggregation was used to prepare slides from eight cases which were hybridized using alpha-satellite enumeration probes for chromosomes 8, 11 and 17. Trisomy 8 and 11 were detected in a high percentage of nuclei in cases of congenital/infantile fibrosarcomas (ranging from 45 to 80%), and in a low grade fibrosarcoma in an older child (23%). Only gains of chromosome 17 were detected in a case of infantile fibromatosis (22%). In this study we have found that given the unconventional histopathologic features, the detection of more than one non-random chromosomal gains by FISH, may aid in further defining fibrous tumors in children, and may be useful as an ancillary diagnostic test in the future.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Flores-Stadler EM,Chou PM,Barquin N,Thangavelu M,Gonzalez-Crussi Fdoi
10.3892/ijo.17.3.433keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
433-7issue
3eissn
1019-6439issn
1791-2423journal_volume
17pub_type
杂志文章abstract::Clinicopathological assessment of the functional relationship between the HER2 oncogene and tumor-associated fatty acid synthase (FASN) is largely precluded because immunohistochemical and/or mRNA studies should be performed in biopsies from breast cancer patients. We here sought to determine whether serum FASN (sFASN...
journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:10.3892/ijo.2018.4630
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更新日期:1992-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.7.5.1117
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3000
更新日期:2015-07-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.4.4.983
更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2007-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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更新日期:2017-06-01 00:00:00
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