Abstract:
:Tumour growth is frequently associated with massive loss of body weight and negative nitrogen balance leading to cachexia, one of the worst features of malignancy accounting for nearly two thirds of cancer deaths. At the metabolic level, cachexia is associated with depletion of body lipid stores as well as loss of skeletal muscle protein, which is manifested as an excessive nitrogen loss. The present study reviews the modulations of nitrogen metabolism in tumour-bearing conditions. In addition, the role of different mediators (such as cytokines) in the development of protein wasting is discussed. Particular emphasis has been given to tumour necrosis factor-alpha (TNF-alpha) which seems to have a key role in mediating changes related to nitrogen metabolism in the tumour-bearing host.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Argilés JM,Costelli P,Carbó N,Pallarés-Trujillo J,López-Soriano FJkeywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
479-86issue
3eissn
1019-6439issn
1791-2423journal_volume
14pub_type
杂志文章,评审abstract::A number of glycosyltransferases have been identified and biologically characterized in cancer cells, yet their exact pathophysiological functions are largely unknown. Here, we report the critical role of β1,3-N-acetylgalactosaminyltransferase II (B3GALNT2), which transfers N-acetylgalactosamine (GalNAc) in a β1,3 lin...
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