Frequent expression of sialyl Le(a) in human esophageal squamous cell carcinoma.

abstract：:Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...

journal_title：International journal of oncology

authors： Otsuki T,Fujimoto D,Hirono Y,Goi T,Yamaguchi A

更新日期：2014-12-01 00:00:00

abstract：:We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...

journal_title：International journal of oncology

authors： Kolzau T,Deppert W

更新日期：1993-07-01 00:00:00

abstract：:We previously showed that the B cell leukemia cell line NALM-6 had the highest susceptibility among a number of leukemia cell lines to spiruchostatin B (SP-B), a potent histone deacetylase (HDAC) inhibitor. We also showed that SP-B-induced cytotoxicity depended on induction of apopt...

journal_title：International journal of oncology

authors： Kanno S,Maeda N,Tomizawa A,Yomogida S,Katoh T,Ishikawa M

更新日期：2012-09-01 00:00:00

abstract：:Neuroblastoma (NB) is one of the most common extracranial solid tumors in children, which has complex molecular mechanisms. Increasing evidence has suggested that long noncoding RNAs (lncRNAs) account for NB pathogenesis. However, the function of small nucleolar RNA host gene 16 (SNHG16) in NB is currently unclear. In...

journal_title：International journal of oncology

authors： Yu Y,Chen F,Yang Y,Jin Y,Shi J,Han S,Chu P,Lu J,Tai J,Wang S,Yang W,Wang H,Guo Y,Ni X

更新日期：2019-07-01 00:00:00

abstract：:We compared the responses of c-Jun/AP-1 transcriptional complexes with those of NF-kappa B, an established hypoxia-inducible transcriptional complex, in hypoxic SiHa human squamous carcinoma cells. We observed that NF-kappa B was activated rapidly, while AP-1 activation was detectable only after prolonged hypoxia. How...

journal_title：International journal of oncology

authors： Laderoute K,Calaoagan J,Mendonca H,Ausserer W,Chen E,Giaccia A,Sutherland R

更新日期：1996-05-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associ...

journal_title：International journal of oncology

authors： Zeng H,Xu N,Liu Y,Liu B,Yang Z,Fu Z,Lian C,Guo H

更新日期：2017-08-01 00:00:00

abstract：:CA IX is a tumor-associated transmembrane isoform of the carbonic anhydrase with a high enzyme activity and a functional involvement in the pH regulation and cell adhesion. Expression of CA9 gene in tumor cells is principally regulated by the high cell density and the hypoxia-related VHL-HIF pathway. In renal cell car...

journal_title：International journal of oncology

authors： Jakubicková L,Biesová Z,Pastoreková S,Kettmann R,Pastorek J

更新日期：2005-04-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:Tumour growth is frequently associated with massive loss of body weight and negative nitrogen balance leading to cachexia, one of the worst features of malignancy accounting for nearly two thirds of cancer deaths. At the metabolic level, cachexia is associated with depletion of body lipid stores as well as loss of ske...

journal_title：International journal of oncology

authors： Argilés JM,Costelli P,Carbó N,Pallarés-Trujillo J,López-Soriano FJ

更新日期：1999-03-01 00:00:00

abstract：:Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...

journal_title：International journal of oncology

authors： Shaughnessy M,Lamuraglia G,Klebanov N,Ji Z,Rajadurai A,Kumar R,Flaherty K,Tsao H

更新日期：2019-11-01 00:00:00

abstract：:Recently, the inflammatory cytokine IL-6 has been reported as a potent inducer of epithelial-mesenchymal transition (EMT) in breast cancer cells with an epithelial phenotype. Furthermore, EMT induces stem cell features in normal and transformed mammary cells. We explored whether IL-...

journal_title：International journal of oncology

authors： Xie G,Yao Q,Liu Y,Du S,Liu A,Guo Z,Sun A,Ruan J,Chen L,Ye C,Yuan Y

更新日期：2012-04-01 00:00:00

abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells (APCs), that have so far been applied for cancer specific immunotherapy. Recent results suggest that matured DCs derived from human monocytes have a significant impact on the outcome of vaccination. The conventional generation of mature DCs from human monocyt...

journal_title：International journal of oncology

authors： Tanaka F,Yamaguchi H,Haraguchi N,Mashino K,Ohta M,Inoue H,Mori M

更新日期：2006-11-01 00:00:00

abstract：:Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...

journal_title：International journal of oncology

authors： Gil EY,Jo UH,Jeong H,Whang YM,Woo OH,Cho KR,Seo JH,Kim A,Lee ES,Koh I,Kim YH,Park KH

更新日期：2012-08-01 00:00:00

abstract：:We showed in our previous study that cancer upregulated gene (CUG) 2, a novel oncogene, confers resistance to infection of oncolytic vesicular stomatitis virus (VSV) by activating Stat1-mediated signal transduction. Since many studies have reported that autophagy is involved in virus replication, we investigated wheth...

journal_title：International journal of oncology

authors： Malilas W,Koh SS,Lee S,Srisuttee R,Cho IR,Moon J,Kaowinn S,Johnston RN,Chung YH

更新日期：2014-04-01 00:00:00

abstract：:A total of forty-one tumor infiltrating T cell lines (TIL) were cloned, in the presence of interleukin-2, from nine breast tumor and five melanoma specimens with limiting dilution in a microculture system. Nineteen (46%) of the lines/clones reacted to autologous tumor targets. The T cell receptor (TcR) V beta gene usa...

journal_title：International journal of oncology

authors： Chin Y,Janssens J,Bleus J,Vandevijver C,Zhang J,Raus J

更新日期：1995-07-01 00:00:00

abstract：:Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulation of hTERT. All-trans retinoic acid (ATRA) induces differentiation in...

journal_title：International journal of oncology

authors： Love WK,Berletch JB,Andrews LG,Tollefsbol TO

更新日期：2008-03-01 00:00:00

abstract：:We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha). High incidence of lymphoma development in this transgenic mouse model system was similar to lymphoma development in p53 knockout mice. In an effort to understand the molecular basis of lymphomagenesis...

journal_title：International journal of oncology

authors： Haidar MA,Manshouri T,Keating MJ,Kantarjian HM,Freireich EJ,Mehta K,Albitar M

更新日期：2000-03-01 00:00:00

abstract：:Specific chromosomal abnormalities, such as del(7q), t(12;14), 12 trisomy, or the rearrangement of 6p, are seen in approximately 30% of uterine leiomyomas despite their benign status. We investigated the association between the shrinkage of uterine leiomyomas treated with a GnRH agonist and the interstitial deletion o...

journal_title：International journal of oncology

authors： Takahashi K,Kawamura N,Tsujimura A,Ichimura T,Ito F,Ishiko O,Ogita S

更新日期：2001-06-01 00:00:00

abstract：:Inhibin and activin, members of transforming growth factor beta (TGF beta) superfamily, have been localized immunohistochemically in fetal bovine heart endothelial cells (FBHE), suggesting that these cells produce inhibin/activin proteins. In addition, the mRNAs coding for alpha-, and beta A-subunits of inhibin/activi...

journal_title：International journal of oncology

authors： Ying S,Zhang Z

更新日期：1995-10-01 00:00:00

abstract：:EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC). Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce the downstream signaling pathways and induce EGFR internalization. This study aims to investigate the role of the EGFR signaling pathway and EG...

journal_title：International journal of oncology

authors： Rebucci M,Peixoto P,Dewitte A,Wattez N,De Nuncques MA,Rezvoy N,Vautravers-Dewas C,Buisine MP,Guerin E,Peyrat JP,Lartigau E,Lansiaux A

更新日期：2011-01-01 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-...

journal_title：International journal of oncology

authors： Ouelaa-Benslama R,De Wever O,Hendrix A,Sabbah M,Lambein K,Land D,Prévost G,Bracke M,Hung MC,Larsen AK,Emami S,Gespach C

更新日期：2012-07-01 00:00:00

abstract：:The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent with high tumor-selective cytotoxicity. The congenital and acquired resistance of some cancer types including malignant melanoma and osteosarcoma impede the current TRAIL therapy of these cancers. Since fine...

journal_title：International journal of oncology

authors： Ohshima Y,Takata N,Suzuki-Karasaki M,Yoshida Y,Tokuhashi Y,Suzuki-Karasaki Y

更新日期：2017-10-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00

abstract：:Orlistat is an orally administered anti-obesity drug that has shown significant antitumor activity in a variety of tumor cells. To identify the proteins involved in its antitumor activity, we employed a proteomic approach to reveal protein expression changes in the human ovarian can...

journal_title：International journal of oncology

authors： Huang HQ,Tang J,Zhou ST,Yi T,Peng HL,Shen GB,Xie N,Huang K,Yang T,Wu JH,Huang CH,Wei YQ,Zhao X

更新日期：2012-08-01 00:00:00

abstract：:The purpose of this study was to determine whether the synthesis of endogenous nitric oxide (NO) is involved in the apoptosis of murine L929 transformed fibroblasts. L929 parental cells and L929 cells selected for resistance to tumor necrosis factor (TNF-alpha) were incubated in vitro with various concentrations of TN...

journal_title：International journal of oncology

authors： Xie K,Huang S,Dong Z,Fidler I

更新日期：1993-12-01 00:00:00

abstract：:High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA ...

journal_title：International journal of oncology

authors： Schwarm FP,Uhle F,Schänzer A,Acker T,Stein M,Reinges MH,Weischer C,Weigand MA,Uhl E,Kolodziej MA

更新日期：2016-04-01 00:00:00

abstract：:RLIP76, a stress-responsive, multi-functional protein with multi-specific transport activity towards glutathione-conjugates (GS-E) and chemotherapeutic agents is frequently overexpressed in malignant cells. Our recent studies suggest that it plays a prominent anti-apoptotic role selectively in cancer cells. The presen...

journal_title：International journal of oncology

authors： Singhal SS,Sehrawat A,Mehta A,Sahu M,Awasthi S

更新日期：2009-01-01 00:00:00

abstract：:Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...

journal_title：International journal of oncology

authors： Jung J,Jeong SY,Park SS,Shin SH,Ju EJ,Choi J,Park J,Lee JH,Kim I,Suh YA,Hwang JJ,Kuroda S,Lee JS,Song SY,Choi EK

更新日期：2015-03-01 00:00:00

abstract：:The purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (IAPs), their inhibitor, Smac, and the focal adhesion kinase (FAK) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, NCCIT. We demonstrated that specifically in laminin-adheren...

journal_title：International journal of oncology

authors： Andjilani M,Droz JP,Benahmed M,Tabone E

更新日期：2006-02-01 00:00:00