Messenger-rnas for activin and activin receptors are expressed in fetal bovine heart endothelial-cells.

abstract：:Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets for metastatic melanoma. A library of 160 well-characterised and potent protein kinase inhibitors was screened in the BRAF muta...

journal_title：International journal of oncology

authors： Mahgoub T,Eustace AJ,Collins DM,Walsh N,O'Donovan N,Crown J

更新日期：2015-09-01 00:00:00

abstract：:The development of targeted molecular therapies has greatly benefited patients with lung adenocarcinomas. In contrast, these treatments have had little benefit in the management of lung squamous cell carcinoma (lung SCC). Therefore, new treatment options based on current genomic approaches are needed for lung SCC. Abe...

journal_title：International journal of oncology

authors： Kumamoto T,Seki N,Mataki H,Mizuno K,Kamikawaji K,Samukawa T,Koshizuka K,Goto Y,Inoue H

更新日期：2016-11-01 00:00:00

abstract：:We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR...

journal_title：International journal of oncology

authors： Schimanski CC,Jordan M,Schlaegel F,Schmidtmann I,Lang H,Galle PR,Moehler M,Gockel I

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this study was to test the hypothesis that cooperative interaction between cutaneous fatty acid-binding protein (C-FABP) and peroxisome proliferator-activated receptors (PPAR) promotes the malignant progression of human prostate cancer. The expression of C-FABP, PPARβ/δ and PPARγ was measured by western...

journal_title：International journal of oncology

authors： Forootan FS,Forootan SS,Malki MI,Chen D,Li G,Lin K,Rudland PS,Foster CS,Ke Y

更新日期：2014-01-01 00:00:00

abstract：:Antisense oligonucleotides that selectively inhibit gene expression are a genetic approach for disease treatment and prevention. However, their use as therapeutic agents is complicated by their low rate of transport across cellular membranes and their sequestration within endocytic-like vesicles. We report that the ad...

journal_title：International journal of oncology

authors： Smith CC,Kulka M,Aurelian L

更新日期：2000-10-01 00:00:00

abstract：:The effects of pretreatment with the multidrug resistance (MDR) modulators verapamil (VPM), tamoxifen (TMX), cyclosporin A (CsA), and SDZ PSC833 (PSC) on drug sensitivity of the P-glycoprotein (Pgp) expressing human ileocecal carcinoma cell line HCT-8 is described. Following pretreatment of 2, 16 and 48 h with the ind...

journal_title：International journal of oncology

authors： Haberl I,Swatonek H,Schaufler K,Ulsperger E,Wenzl E,Theyer G,Hamilton G,Thalhammer T

更新日期：1998-05-01 00:00:00

abstract：:The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of ...

journal_title：International journal of oncology

authors： Micallef M,Ariyasu T,Dao T,Matsuo Y,Minowada J

更新日期：1994-03-01 00:00:00

abstract：:Magnolol, a neolignan from the traditional medicinal plant Magnolia obovata, has been shown to possess neuroprotective, anti-inflammatory, anticancer and anti-angiogenic activities. However, the precise mechanism of the anti-angiogenic activity of magnolol remains to be elucidated. In the present study, the anti-angio...

journal_title：International journal of oncology

authors： Kim GD,Oh J,Park HJ,Bae K,Lee SK

更新日期：2013-08-01 00:00:00

abstract：:Although only less than 10% of women with primary breast cancer have clinicopathologic signs of overt metastases, metastatic relapse occurs in about half of the cases with apparently localized tumors within five years after surgery. In 23% of the patients, bone marrow metastases are detectable at first relapse and thi...

journal_title：International journal of oncology

authors： Kasimir-Bauer S,Oberhoff C,Schindler AE,Seeber S

更新日期：2002-05-01 00:00:00

abstract：:Approval of the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab by the FDA in 2004 reflected the success of this vascular targeting strategy in extending survival in patients with advanced cancers. However, consistent with previous reports that experimental tumors can grow or recur during VEGF bloc...

journal_title：International journal of oncology

authors： Huang J,Bae JO,Tsai JP,Kadenhe-Chiweshe A,Papa J,Lee A,Zeng S,Kornfeld ZN,Ullner P,Zaghloul N,Ioffe E,Nandor S,Burova E,Holash J,Thurston G,Rudge J,Yancopoulos GD,Yamashiro DJ,Kandel JJ

更新日期：2009-01-01 00:00:00

abstract：:VEGF, Hedgehog, FGF, Notch, and WNT signaling pathways network together for vascular remodeling during embryogenesis, tissue regeneration, and carcinogenesis. VEGFA (VEGF), VEGFB, VEGFC, VEGFD (FIGF) and PGF (PlGF) are VEGF family ligands for receptor tyrosine kinases, including VEGFR1 (FLT1), VEGFR2 (KDR) and VEGFR3 ...

journal_title：International journal of oncology

authors： Katoh Y,Katoh M

更新日期：2006-06-01 00:00:00

abstract：:Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptio...

journal_title：International journal of oncology

authors： Alqahtani T,Kumarasamy VM,Huczyński A,Sun D

更新日期：2020-01-01 00:00:00

abstract：:Chemotherapeutic treatment with combinations of drugs is front-line therapy for many types of cancer. Combining drugs that target different signaling pathways often lessens adverse side-effects while increasing the efficacy of treatment and reducing patient morbidity. Histone deacetylase (HDAC) inhibitors represent a ...

journal_title：International journal of oncology

authors： Sato T,Suzuki M,Sato Y,Echigo S,Rikiishi H

更新日期：2006-05-01 00:00:00

abstract：:Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against brea...

journal_title：International journal of oncology

authors： Echiburú-Chau C,Alfaro-Lira S,Brown N,Salas CO,Cuellar M,Santander J,Ogalde JP,Rothhammer F

更新日期：2014-04-01 00:00:00

abstract：:To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% o...

journal_title：International journal of oncology

authors： Molendini L,Benassi MS,Magagnoli G,Merli M,Sollazzo MR,Ragazzini P,Gamberi G,Ferrari C,Balladelli A,Bacchini P,Picci P

更新日期：1998-05-01 00:00:00

abstract：:Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of CDC20 in hepatocellular carc...

journal_title：International journal of oncology

authors： Li J,Gao JZ,Du JL,Huang ZX,Wei LX

更新日期：2014-10-01 00:00:00

abstract：:Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...

journal_title：International journal of oncology

authors： Liu ZY,Qiu HO,Yuan XJ,Ni YY,Sun JJ,Jing W,Fan YZ

更新日期：2012-11-01 00:00:00

abstract：:Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...

journal_title：International journal of oncology

authors： Dittmer A,Lange T,Leyh B,Dittmer J

更新日期：2020-01-01 00:00:00

abstract：:PDZ-domain protein GIPC1/GIPC interacts with GTPase-activating protein RGS-GAIP, TGFbeta type III receptor, and integrin alpha6A subunit. Kermit, a Xenopus orthologue of human GIPC1, interacts with some class of WNT receptor. In this study, we identified a novel GIPC1-related gene in human genome by using bioinformati...

journal_title：International journal of oncology

authors： Kirikoshi H,Katoh M

更新日期：2002-03-01 00:00:00

abstract：:Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...

journal_title：International journal of oncology

authors： Spann AL,Yuan K,Goliwas KF,Steg AD,Kaushik DD,Kwon YJ,Frost AR

更新日期：2015-07-01 00:00:00

abstract：:Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...

journal_title：International journal of oncology

authors： Jung KH,Ryu YL,Lee HS,Lee H,Son MK,Yan HH,Hong SW,Ryu JK,Hong S,Suh JK,Hong SS

更新日期：2013-06-01 00:00:00

abstract：:A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovar...

journal_title：International journal of oncology

authors： Yokomizo A,Tindall DJ,Hartmann L,Jenkins RB,Smith DI,Liu W

更新日期：1998-07-01 00:00:00

abstract：:The hepatitis B virus (HBV) encodes a 16.5 kDa multifunctional protein termed pX or HBx, required for transcription of the viral genome and implicated in the development of hepatocellular carcinoma (HCC) in chronic HBV-infected patients. However, the mechanism of pX-mediated hepatocarcinogenesis remains unknown. pX is...

journal_title：International journal of oncology

authors： Andrisani OM,Barnabas S

更新日期：1999-08-01 00:00:00

abstract：:We have previously shown that the genotoxin-induced apoptosis in mouse embryo fibroblasts was enhanced by the extracellular matrix protein fibronectin (FN). In the present study, we tested the hypothesis that FN regulates the DNA damage response (DDR) signaling pathways in HCT116 (p53-wt) and HT29 (p53-mut) human colo...

journal_title：International journal of oncology

authors： DE Wever O,Sobczak-Thépot J,Vercoutter-Edouart AS,Michalski JC,Ouelaa-Benslama R,Stupack DG,Bracke M,Wang JYJ,Gespach C,Emami S

更新日期：2011-08-01 00:00:00

abstract：:Cytogenetic analyses of peripheral blood cells of breast cancer patients unveiled in one case a grossly enlarged G-band in one copy of chromosome 16 (16qh+), which scored also strongly positive in C-banding. Fluorescence in situ hybridization with both a total chromosome 16 library and with probe pHuR195 detecting loc...

journal_title：International journal of oncology

authors： Savelyeva L,Schneider B,Finke L,Schlag P,Schwab M

更新日期：1994-02-01 00:00:00

abstract：:Cervical lymph node metastasis is the most common recurrence pattern of head and neck squamous cell carcinoma (HNSCC), and it is usually treated with radiation therapy and/or neck dissection. There has long been a desire for markers useful in predicting radiosensitivity to enable assignment of patients with recurrent ...

journal_title：International journal of oncology

authors： Ito Y,Kamijo T,Yokose T,Kawashima M,Ogino T,Ikeda H,Hayashi R,Sasaki S,Ochiai A

更新日期：2001-12-01 00:00:00

abstract：:'Rare sugars' are defined as monosaccharides that exist in nature but are only present in limited quantities. The development of mass production method of rare sugars revealed some interesting physiological effects of these on animal cells, but the mechanisms have not been well studied. We examined the effect of D-all...

journal_title：International journal of oncology

authors： Yamaguchi F,Takata M,Kamitori K,Nonaka M,Dong Y,Sui L,Tokuda M

更新日期：2008-02-01 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for human breast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, is a well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. I...

journal_title：International journal of oncology

authors： Huynh H,Beamer W,Pollak M,Chan TW

更新日期：2000-02-01 00:00:00

abstract：:Oxygen tension measurements were made in three tumors: (i) the murine FSaII fibrosarcoma, (ii) the rat 9L gliosarcoma and (iii) the rat 13672 mammary adenocarcinoma using a pO2 histograph. Tumor oxygenation measurements were made while the animals breathed air or breathed carbogen (95% oxygen/5% carbon dioxide). Pento...

journal_title：International journal of oncology

authors： Teicher B,Sotomayor E,Robinson M,Dupuis N,Schwartz G,Frei E

更新日期：1993-01-01 00:00:00

abstract：:Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...

journal_title：International journal of oncology

authors： Devor EJ,Gonzalez-Bosquet J,Thiel KW,Leslie KK

更新日期：2020-12-01 00:00:00