Abstract:
:The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of differentiation, and normal thymocytes was examined using reverse transcriptase-polymerase chain reaction (RT-PCR). Fourteen of 16 T cell lines expressed the gene for TGF-beta1 and 12 of the cell lines also expressed the gene for GM-CSF. None of the 5 normal thymocyte samples constitutively expressed RNA for TGF-beta1 or GM-CSF. One cell line established from a patient with adult T cell leukemia (ATL), ED-S-, expressed the genes for TGF-beta1, GM-CSF, IL-10, IL-12, IFN-gamma and MIP-1alpha. IL-9 was not expressed by any cell line, IL-10 was expressed by only three cell lines and IL-12 was expressed by only two cell lines. The production of immunosuppressive factors such as TGF-beta1 by T leukemic cells is a possible mechanism for the clinical progression of this disease.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Micallef M,Ariyasu T,Dao T,Matsuo Y,Minowada Jdoi
10.3892/ijo.4.3.633subject
Has Abstractpub_date
1994-03-01 00:00:00pages
633-8issue
3eissn
1019-6439issn
1791-2423journal_volume
4pub_type
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:10.3892/ijo.2014.2513
更新日期:2014-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.22.4.861
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更新日期:2004-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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journal_title:International journal of oncology
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更新日期:1996-01-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2004-03-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2004-10-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:2004-11-01 00:00:00