High-dose chemotherapy in the treatment of breast-cancer.

abstract：:Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...

journal_title：International journal of oncology

authors： Markaverich B,Alejandro M

更新日期：1997-12-01 00:00:00

abstract：:Gliomas are malignant brain tumors thought to arise through multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cyclin D1 gene encodes a proto-oncogenic cell cycle regulator implicated in the pathogenesis of several types of cancer, including gliomas. Northe...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-09-01 00:00:00

abstract：:Steroid receptor analysis is the only widely accepted prognostic/predictive marker in breast cancer (BC) treatment. In the present study we evaluated the prognostic role of ER/PgR with p53 and Bcl2, in a series of 277 BC (153 pN1/2, 122 pNO, 2 pNx) with a long-term follow-up (67 months for DFS, 75 months for OS). Our ...

journal_title：International journal of oncology

authors： Mauri FA,Maisonneuve P,Caffo O,Veronese S,Aldovini D,Ferrero S,Cozzaglio F,Dalla Palma P,Galligioni E,Barbareschi M

更新日期：1999-12-01 00:00:00

abstract：:Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vecto...

journal_title：International journal of oncology

authors： Yamanaka R

更新日期：2004-04-01 00:00:00

abstract：:Human breast cancer is a major cause of global morbidity and mortality in women and it is a process that involves numerous molecular and cellular alterations attributed to environmental substances and agents such as hormones. Bisphosphonates, such as pamidronate, are potent antiresorptive drugs used to the treatment o...

journal_title：International journal of oncology

authors： Ponce-Cusi R,Calaf GM

更新日期：2015-01-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Sialic acid-containing glycosphingolipids, gangliosides, are expressed at high levels in the nerve tissues and various tumor cells. Although a number of studies on the roles of gangliosides in the regulation of cell proliferation have been performed, the mechanisms for the regulation are not well understood. We establ...

journal_title：International journal of oncology

authors： Nishio M,Tajima O,Furukawa K,Urano T,Furukawa K

更新日期：2005-01-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) is an important regulator of cell development and differentiation of various organs. Tumorigenesis and tumor progression are also strongly associated with changes of the fate of cells which are highly differentiated in healthy tissues. Therefore, we studied the role of BMP-7 in bre...

journal_title：International journal of oncology

authors： Schwalbe M,Sänger J,Eggers R,Naumann A,Schmidt A,Höffken K,Clement JH

更新日期：2003-07-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...

journal_title：International journal of oncology

authors： Wang H,Dai YY,Zhang WQ,Hsu PC,Yang YL,Wang YC,Chan G,Au A,Xu ZD,Jiang SJ,Wang W,Jablons DM,You L

更新日期：2017-07-01 00:00:00

abstract：:In the multistep progressive pathogenesis of human breast cancer, comedo ductal carcinoma in situ (DCIS) represents a preinvasive precursor lesion for therapy resistant invasive cancer. Human tissue derived cell culture models exhibiting molecular similarities to clinical DCIS facilitate an important preclinical mecha...

journal_title：International journal of oncology

authors： Katdare M,Osborne M,Telang NT

更新日期：2002-10-01 00:00:00

abstract：:The proper structure of the extracellular matrix, in particular of the basement membrane and the adjacent interstitial matrix, are essential prerequisites for a proper function of tissues. Invasive growth in malignant tumors is associated with a destruction of various matrix structures. Due to extensive recent analyse...

journal_title：International journal of oncology

authors： Hagedorn HG,Bachmeier BE,Nerlich AG

更新日期：2001-04-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...

journal_title：International journal of oncology

authors： Jung KH,Ryu YL,Lee HS,Lee H,Son MK,Yan HH,Hong SW,Ryu JK,Hong S,Suh JK,Hong SS

更新日期：2013-06-01 00:00:00

abstract：:Cyclin-dependent kinase (CDK) inhibitor p27Kip1 is a diagnostic and prognostic marker of various malignancies. Low expression of p27Kip1 reflects poor prognosis, and an inverse correlation between the expression of p27Kip1 and degree of tumor malignancy has been reported. Because p27Kip1 mutation is extremely rare in ...

journal_title：International journal of oncology

authors： Supriatno,Harada K,Yoshida H,Sato M

更新日期：2005-09-01 00:00:00

abstract：:Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease. Polysaccharide-K® (PSK), an extract of the mushroom Trametes versicolor, has immunomodulatory and tumor suppressive a...

journal_title：International journal of oncology

authors： Wenner CA,Martzen MR,Lu H,Verneris MR,Wang H,Slaton JW

更新日期：2012-04-01 00:00:00

abstract：:The presence of arachidonate 12-lipoxygenase (12-LOX) potentiates prostate cancer (PCa) progression and therefore may be a good therapeutic target and/or a potential diagnostic predictor for PCa. In this study, we examined the expression of 12-LOX in PCa stem cells (PCa SCs) to test if it can serve as a unique marker ...

journal_title：International journal of oncology

authors： Yin B,Yang Y,Zhao Z,Zeng Y,Mooney SM,Li M,Xu X,Song Y,Wu B,Yang Z

更新日期：2011-04-01 00:00:00

abstract：:Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...

journal_title：International journal of oncology

authors： Ortega MA,Fraile-Martínez O,García-Honduvilla N,Coca S,Álvarez-Mon M,Buján J,Teus MA

更新日期：2020-12-01 00:00:00

abstract：:The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 was clearly demonstrated in two independent PLAG1 transgenic mouse founders, in which PLAG1 expression could be targeted to different tissues usin...

journal_title：International journal of oncology

authors： Declercq J,Van Dyck F,Van Damme B,Van de Ven WJ

更新日期：2008-05-01 00:00:00

abstract：:We have previously isolated a drug-resistant, [PC3(R)], variant of human prostate PC3 cell line, which showed significant resistance (>10-fold) to adriamycin. No known mechanisms of drug resistance were found; however, resistant cells expressed more bcl2, c-myc, and ms oncogenes compared to the sensitive cells. In thi...

journal_title：International journal of oncology

authors： Sinha B,Song K

更新日期：1997-10-01 00:00:00

abstract：:We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha). High incidence of lymphoma development in this transgenic mouse model system was similar to lymphoma development in p53 knockout mice. In an effort to understand the molecular basis of lymphomagenesis...

journal_title：International journal of oncology

authors： Haidar MA,Manshouri T,Keating MJ,Kantarjian HM,Freireich EJ,Mehta K,Albitar M

更新日期：2000-03-01 00:00:00

abstract：:Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...

journal_title：International journal of oncology

authors： Koseki J,Colvin H,Fukusumi T,Nishida N,Konno M,Kawamoto K,Tsunekuni K,Matsui H,Doki Y,Mori M,Ishii H

更新日期：2015-03-01 00:00:00

abstract：:Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). Identification of methylated genes is necessary to improve our understanding of the pathogenesis of HCC and develop novel biomarkers and therapeutic targe...

journal_title：International journal of oncology

authors： Tanaka Y,Kanda M,Sugimoto H,Shimizu D,Sueoka S,Takami H,Ezaka K,Hashimoto R,Okamura Y,Iwata N,Tanaka C,Yamada S,Fujii T,Nakayama G,Koike M,Nomoto S,Fujiwara M,Kodera Y

更新日期：2015-01-01 00:00:00

abstract：:Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/...

journal_title：International journal of oncology

authors： Mizutani Y,Katsuoka Y,Bonavida B

更新日期：2012-04-01 00:00:00

abstract：:Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

journal_title：International journal of oncology

authors： Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

更新日期：2004-05-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy and highlighting ...

journal_title：International journal of oncology

authors： Du Y,Shi A,Han B,Li S,Wu D,Jia H,Zheng C,Ren L,Fan Z

更新日期：2014-04-01 00:00:00

abstract：:Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...

journal_title：International journal of oncology

authors： Hadisaputri YE,Miyazaki T,Yokobori T,Sohda M,Sakai M,Ozawa D,Hara K,Honjo H,Kumakura Y,Kuwano H

更新日期：2017-03-01 00:00:00

abstract：:BALB/c 3T3 cells transformed by 1,1,2,2-tetrachloroethane, the most toxic chloroethane, acquired a fully malignant phenotype. They were capable of growing in soft agar, were tumorigenic when injected in athymic mice and produced pulmonary nodules after i.v. injection. Untreated BALB/c 3T3 cells were weakly tumorigenic...

journal_title：International journal of oncology

authors： Colacci A,Albini A,Melchiori A,Nanni P,Nicoletti G,Noonan D,Parodi S,Grilli S

更新日期：1993-06-01 00:00:00