Abstract:
:We have initiated studies to enhance targeted delivery of an anticancer agent, curcumin, for prostate cancer treatment by incorporating this agent into the liposomes (nanodelivery vehicles primarily composed of phospholipids) coated with prostate membrane specific antigen specific antibodies. We prepared curcumin-loaded liposomes of various lipid compositions by sonication at an average size of 100-150 nm. Un-entrapped curcumin was removed by size exclusion chromatography. Data show that curcumin preferentially partitioned into liposomes prepared from dimyristoyl phosphatidyl choline (DMPC) and cholesterol among the various compositions tested. The anti-proliferative activity of liposomal curcumin was studied using two human prostate cancer cell lines (LNCaP and C4-2B) by a tetrazolium dye-based (MTT) assay. Treatment of cells with liposomal curcumin (5-10 microM) for 24-48 h at 37 degrees C resulted in at least 70-80% inhibition of cellular proliferation without affecting their viability. On the other hand, free curcumin exhibited similar inhibition only at 10-fold higher doses (>50 microM). We also observed that LNCaP cells were relatively more sensitive to liposomal curcumin mediated block of cellular proliferation than C4-2B cells. We are currently developing liposome formulations with targeting ability to further improve the efficacy of curcumin in vivo.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Thangapazham RL,Puri A,Tele S,Blumenthal R,Maheshwari RKsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
1119-23issue
5eissn
1019-6439issn
1791-2423journal_volume
32pub_type
杂志文章abstract::Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and is highly resistant to conventional cancer therapy. A better understanding of the regulatory mechanisms which control the growth of this deadly malignancy are urgently needed to develop more effective cancer intervention strategies. Recent studies h...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::The insulin-like growth factors (IGFs) are a family of mitogenic proteins involved in the regulation of cell growth and differentiation. The presence and role of the IGF system in oral mucosal epithelium is not clear but could influence our understanding of the pathogenesis of oral cancer. We characterised the express...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract::Chemokine-mediated activation of G protein-coupled receptors CXCR1/2 promotes tumor growth, invasion, inflammation and metastasis. Repertaxin, a CXCR1/2 small-molecule inhibitor, has been shown to attenuate many of these tumor-associated processes. The present study aimed to investigate the effects of repertaxin alone...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3371
更新日期:2016-04-01 00:00:00
abstract::BALB/c 3T3 cells transformed by 1,1,2,2-tetrachloroethane, the most toxic chloroethane, acquired a fully malignant phenotype. They were capable of growing in soft agar, were tumorigenic when injected in athymic mice and produced pulmonary nodules after i.v. injection. Untreated BALB/c 3T3 cells were weakly tumorigenic...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.6.937
更新日期:1993-06-01 00:00:00
abstract::Serial analysis of gene expression (SAGE) is a sequence-based tool that enables quantitative study of comprehensive gene expression profiles. In this study, we generated a SAGE library of hepatitis B virus (HBV)-associated small hepatocellular carcinoma (HCC) and compared it with libraries of normal liver and other or...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000321
更新日期:2009-07-01 00:00:00
abstract::Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not wel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2647
更新日期:2014-12-01 00:00:00
abstract::The intention of a surveillance program to monitor prostate cancer patients is to detect recurrence of disease as soon as possible and institute therapy at the time of recurrence in order to improve the chance of cure or extend survival. We analyzed the cost of four surveillance programs for prostate cancer. As PSA le...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.3.473
更新日期:1993-03-01 00:00:00
abstract::Bone is a common site of osteolytic and richly vascularized metastases of renal cell carcinoma (RCC) and Interferon (IFN)-alpha based therapies have been considered for the treatment of patients affected by this disease. The effects of IFN-alpha on metastatic RCC patients have been related to its immunomodulatory, and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-01 00:00:00
abstract::Meningiomas are the most commonly occurring intracranial tumors and account for approximately 15-20% of central nervous system tumors. Patients whose tumors recur after surgery and radiation therapy have limited therapeutic options. It has also been reported recently that radiation triggers DNA repair, cell survival a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.934
更新日期:2011-04-01 00:00:00
abstract::Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3006
更新日期:2015-07-01 00:00:00
abstract::Multiple myeloma (MM) patients initially respond to conventional therapy, however, many develop resistance and have recurrences. We have reported in other tumors that the transcription factor Yin Yang 1 (YY1) is a resistant factor and, thus, we hypothesized that YY1 may be over-expressed in MM. Significantly, higher e...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2511
更新日期:2014-09-01 00:00:00
abstract::The development of carcinoma is associated with alterations in the expression of many cell adhesion molecules. Syndecan-1 is a cell surface proteoglycan that binds cells to the extracellular matrix and changes its expression following malignant transformation in some tumors. Our purpose was to examine the pattern of s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Seven ovarian and one cervical human cancer cell lines were examined far their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and to...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Endoscopic examination with iodine staining has led to the easy detection of multiple superficial esophageal carcinoma (MSEC). The purpose of this study was to better understand the characteristics of MSEC. Of 49 patients with multiple esophageal carcinomas, 19 had superficial carcinoma. Multiple esophageal carcinomas...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.12.2.421
更新日期:1998-02-01 00:00:00
abstract::Genetically engineered stem cells (GESTECs) producing suicide enzymes and immunotherapeutic cytokines have therapeutic effects on tumors, and may possibly reduce the side effects of toxic drugs used for treatments. Suicide enzymes can convert non-toxic pro-drugs to toxic metabolites that can reduce tumor growth. Cytos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1288
更新日期:2012-04-01 00:00:00
abstract::Cisplatin is widely used for chemotherapy of a variety of human cancers. Cisplatin exerts its toxic effect by covalently binding to DNA, resulting in monofunctional adducts, intrastrand crosslinks, and interstrand crosslinks. Several recent reports suggest that the cellular capacity for DNA repair, especially nucleoti...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.9.6.1121
更新日期:1996-12-01 00:00:00
abstract::The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-randomized trial in h...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:10.3892/ijo.16.6.1227
更新日期:2000-06-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common solid neoplasm of adult kidney, and the major treatment for metastatic RCC (mRCC) is molecular targeted therapy. Sorafenib, as a multi-targeted tyrosine kinase inhibitor (TKI), has significantly improved clinical outcomes of mRCC patients. However, complete or long-term re...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3356
更新日期:2016-04-01 00:00:00
abstract::Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4916
更新日期:2020-01-01 00:00:00
abstract::CXC chemokines have a major influence on the angiogenesis, growth and metastatic potential of pancreatic ductal adenocarcinoma. CXCL16 is a unique transmembrane CXC chemokine, which is shed by members of the disintegrins and metalloproteases (ADAMs), in particular by ADAM10 and ADAM17. In our study, we evaluated expre...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-08-01 00:00:00
abstract::Metastasis is the main challenge of osteosarcoma treatment. Herein, we first reveal the oncogenic role of FAT10 in metastasis of osteosarcoma. FAT10 was upregulated in osteosarcoma, especially in metastatic osteosarcoma. High level of FAT10 was associated with poorer prognosis of osteosarcoma patients. Moreover, Trans...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3549
更新日期:2016-08-01 00:00:00
abstract::Marek's disease virus (MDV) is one of the most oncogenic herpesviruses and the only cancer virus that has a successful vaccine. Based on the short-latency and polyclonal nature of the tumors, it is likely that MDV encodes its own oncogenes. Recent studies have provided insights into possible MDV genes involved in onco...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.5.997
更新日期:1995-05-01 00:00:00
abstract::Gene amplifications occurring in the q13 band of chromosome 11 are frequently observed in head and neck squamous cell carcinomas. In order to determine the relative frequency of amplification in 5 distinct 11q13 loci and their relation with clinical data, tumor DNAs from 31 patients - including 26 who had undergone ne...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.2.309
更新日期:1994-08-01 00:00:00
abstract::Pancreatic cancer is characterized by a dense desmoplastic reaction in which extracellular matrix proteins accumulate and surround tumor cells. Integrins and their related signaling molecules are associated with progression of pancreatic cancer. In the present study, the association between the metastasis of pancreati...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4018
更新日期:2017-07-01 00:00:00
abstract::Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many types of cell lines and tissues have demonstrated the presence of SP cells, including colon cancer cell lines. This study aimed to identify cancer stem cells (CSCs) in the SP of the colon cancer cell line SW480. SP c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2498
更新日期:2014-09-01 00:00:00
abstract::Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4710
更新日期:2019-04-01 00:00:00
abstract::It has been reported that XAF1 expression in gastric cancer is negatively correlated with p53. Our purpose was to clarify the regulatory mechanism of p53 on XAF1 expression. The effects of overexpressed wild-type and mutant p53 on XAF1 expression were evaluated. Binding capacity of core XAF1 promoter sequence to the r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000584
更新日期:2010-04-01 00:00:00
abstract::Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (C...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4692
更新日期:2019-03-01 00:00:00