Chromosome-11q13 gene amplifications in head and neck squamous-cell carcinomas - relation with lymph-node invasion.

abstract：:This retrospective study looks at the differences between adolescents (15-19 years) and young adults (20-25 years), diagnosed with Hodgkin lymphoma and treated at the same adult institution. Outcome according to risk category was evaluated, and although there were no significant differences in the whole cohort, or low...

journal_title：International journal of oncology

authors： Herbertson RA,Evans LS,Hutchinson J,Horsman J,Hancock BW

更新日期：2008-07-01 00:00:00

abstract：:The treatment of glioblastoma is unsatisfactory. Improved understanding of the biological effects of treatment, together with development of new tools to predict outcome of the initiated treatment are therefore of great need. Vandetanib (ZD6474) is mainly a vascular endothelial growth factor (VEGF) and epidermal growt...

journal_title：International journal of oncology

authors： Wibom C,Sandström M,Henriksson R,Antti H,Johansson M,Bergenheim AT

更新日期：2010-10-01 00:00:00

abstract：:Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...

journal_title：International journal of oncology

authors： Lin C,Tsai SC,Tseng MT,Peng SF,Kuo SC,Lin MW,Hsu YM,Lee MR,Amagaya S,Huang WW,Wu TS,Yang JS

更新日期：2013-03-01 00:00:00

abstract：:Liver cancer is the fourth leading cause of cancer‑related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2 (PIM2), has been shown to be overexpressed in liver cancer, ...

journal_title：International journal of oncology

authors： Kronschnabl P,Grünweller A,Hartmann RK,Aigner A,Weirauch U

更新日期：2020-02-01 00:00:00

abstract：:Despite attempts to use multiple drug combinations that include gemcitabine (GEM), there is very little evidence that these combination regimens are superior to the single use of this agent. We therefore investigated the suppressive effect of the combination of systemically administered GEM and locally administered in...

journal_title：International journal of oncology

authors： Ito Y,Aiura K,Ueda M,Kitajima M,Kitagawa Y

更新日期：2008-07-01 00:00:00

abstract：:Cancer represents a severe challenge to healthcare systems and individuals worldwide. The development of multiple drug resistance is a major issue regarding cancer therapy, which can result in the progression of disease. Cholesterol is a major constituent of cell membranes and participates in the regulation of several...

journal_title：International journal of oncology

authors： Yan A,Jia Z,Qiao C,Wang M,Ding X

更新日期：2020-09-22 00:00:00

abstract：:Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...

journal_title：International journal of oncology

authors： Tsai SY,Hsieh TC,Ardelt B,Darzynkiewicz Z,Wu JM

更新日期：2002-05-01 00:00:00

abstract：:The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carc...

journal_title：International journal of oncology

authors： Zhou X,Zimonjic DB,Park SW,Yang XY,Durkin ME,Popescu NC

更新日期：2008-06-01 00:00:00

abstract：:Paclitaxel (taxol) has been used for the treatment of various human tumors and is an exceedingly efficient chemotherapy agent against esophageal cancer. However, the precise molecular mechanisms of paclitaxel effects on human esophageal adenocarcinoma cells are not well understood. MTT assay and cell cycle analysis we...

journal_title：International journal of oncology

authors： Kim SJ,Chung MJ,Kim JS,Kim B,Park WH,Kim SH,Kim SZ,Lee JS,Kim SM

更新日期：2011-12-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...

journal_title：International journal of oncology

authors： Chen J,Schmitt A,Giannopoulos K,Chen B,Rojewski M,Döhner H,Bunjes D,Schmitt M

更新日期：2007-11-01 00:00:00

abstract：:Chlorophyllin (CHL) is the sodium-copper salts of chlorophyll derivatives. In this study, the CHL was derived from a traditional Chinese medicine, the Bombyx mori excreta. The CHL, at concentrations 25-400 microg/ml, reduced the proliferation of HL-60, K-562, S-180, and MCF-7 cells by 8.2-95.7% after 72 h of incubatio...

journal_title：International journal of oncology

authors： Chiu LC,Kong CK,Ooi VE

更新日期：2003-09-01 00:00:00

abstract：:Growth and inflammatory factors are associated with poor prognosis in gastric adenocarcinoma (GA); however, the additive effects of growth and inflammatory factors in GA remain unclear. In this study, we investigated the ability of epidermal growth factor (EGF) and interleukin (IL-1β) to activate extracellular signal-...

journal_title：International journal of oncology

authors： Han J,Xie Y,Lan F,Yu Y,Liu W,Chen J,Zheng F,Ouyang X,Lin X,Lin Y,Huang Q,Wang L,Tan J

更新日期：2014-07-01 00:00:00

abstract：:Early-onset breast cancer is one of the most common malignancies and causes of death among young women, and its incidence is increasing. In the present study, we aimed to investigate the epigenetic modifications of the breast cancer type 1 susceptibility gene (BRCA1) in breast tissues and blood cells derived from wome...

journal_title：International journal of oncology

authors： Al-Moghrabi N,Al-Qasem AJ,Aboussekhra A

更新日期：2011-07-01 00:00:00

abstract：:Meningiomas are the most commonly occurring tumors of the central nervous system including the brain and spinal cord. Malignant meningiomas are highly aggressive and frequently recur after surgical resection of the tumor. Our previous studies have reported that urokinase plasminogen activator receptor (uPAR) and matri...

journal_title：International journal of oncology

authors： Tummalapalli P,Gondi CS,Dinh DH,Gujrati M,Rao JS

更新日期：2007-07-01 00:00:00

abstract：:Wilms' tumor is one of the most common malignant tumors of the abdomen in children. However, there is currently no recognized specific biomarker for the clinical diagnosis and prognosis of this tumor. Lipid metabolism is involved in membrane synthesis and oxidation in tumor cells. This process plays an important role ...

journal_title：International journal of oncology

authors： Wang X,Du G,Wu Y,Zhang Y,Guo F,Liu W,Wu R

更新日期：2020-02-01 00:00:00

abstract：:Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent. In this study, using western blot analysis for protein expression and flow cytometry for cell cycle analysis, we determined that the treatment of the LNCaP and PC‑3 prostate c...

journal_title：International journal of oncology

authors： Oak C,Khalifa AO,Isali I,Bhaskaran N,Walker E,Shukla S

更新日期：2018-08-01 00:00:00

abstract：:Emerging evidence indicates that mesenchymal stem cells (MSCs) serve an indispensable role in the tumor microenvironment. However, whether MSCs participate in the development of oral carcinogenesis remains unclear. The present study isolated MSCs from clinical tissues and investigated the differences of MSCs derived f...

journal_title：International journal of oncology

authors： Li W,Han Y,Zhao Z,Ji X,Wang X,Jin J,Wang Q,Guo X,Cheng Z,Lu M,Wang G,Wang Y,Liu H

更新日期：2019-05-01 00:00:00

abstract：:Expression and functions of interleukin (IL)-8, a pro-inflammatory cytokine with angiogenesis action, was examined in 23 surgically resected hepatocellular carcinoma (HCC) specimens and 7 HCC cell lines. In all HCC tissues, IL-8 expression was confirmed with reverse-transcription polymerase chain reaction method and e...

journal_title：International journal of oncology

authors： Akiba J,Yano H,Ogasawara S,Higaki K,Kojiro M

更新日期：2001-02-01 00:00:00

abstract：:The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...

journal_title：International journal of oncology

authors： Seliger B,Bock M,Ritz U,Huber C

更新日期：2002-02-01 00:00:00

abstract：:Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...

journal_title：International journal of oncology

authors： Sartippour MR,Heber D,Zhang L,Beatty P,Elashoff D,Elashoff R,Go VL,Brooks MN

更新日期：2002-09-01 00:00:00

abstract：:The deregulation of the epidermal growth factor receptor (EGFR) pathway plays a major role in the pathogenesis of prostate cancer (PCa). However, therapies targeting EGFR have demonstrated limited effectiveness in PCa. A potential mechanism to overcome EGFR blockade in cancer cells is the autocrine activation of alter...

journal_title：International journal of oncology

authors： Carrión-Salip D,Panosa C,Menendez JA,Puig T,Oliveras G,Pandiella A,De Llorens R,Massaguer A

更新日期：2012-09-01 00:00:00

abstract：:Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...

journal_title：International journal of oncology

authors： Dittmer A,Lange T,Leyh B,Dittmer J

更新日期：2020-01-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activi...

journal_title：International journal of oncology

authors： Du Y,Long Q,Zhang L,Shi Y,Liu X,Li X,Guan B,Tian Y,Wang X,Li L,He D

更新日期：2015-12-01 00:00:00

abstract：:Gastric carcinoma is the most common cancer and the second most common cause of cancer-related death in Korea. Many studies have been reported regarding prognostic factors. Among the category I prognostic factors of gastric carcinoma, lymph node metastasis (nodal status) is considered to be the strongest prognostic fa...

journal_title：International journal of oncology

authors： Lee SY,Hwang I,Park YS,Gardner J,Ro JY

更新日期：2010-06-01 00:00:00

abstract：:The RON receptor tyrosine kinase and its ligand macrophage stimulating protein (MSP) play a role in epithelial tumorigenesis. We report here a novel RON variant that antagonizes the RON-MSP pathway in various cancer cells. The variant is an 85 kDa soluble protein from an mRNA transcript with an insertion of 49 nucleot...

journal_title：International journal of oncology

authors： Ma Q,Zhang K,Yao HP,Zhou YQ,Padhye S,Wang MH

更新日期：2010-06-01 00:00:00

abstract：:Cervical lymph node metastasis is the most common recurrence pattern of head and neck squamous cell carcinoma (HNSCC), and it is usually treated with radiation therapy and/or neck dissection. There has long been a desire for markers useful in predicting radiosensitivity to enable assignment of patients with recurrent ...

journal_title：International journal of oncology

authors： Ito Y,Kamijo T,Yokose T,Kawashima M,Ogino T,Ikeda H,Hayashi R,Sasaki S,Ochiai A

更新日期：2001-12-01 00:00:00

abstract：:Phosphorylation of histone H2AX (gammaH2AX) is a sensitive marker of DNA damage, particularly induction of DNA double-strand breaks. Using multiparameter cytometry we explored the effects of doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types of endometrioid adenocarcinoma cell lines (HEC-1A, H...

journal_title：International journal of oncology

authors： Ikeda M,Kurose A,Takatori E,Sugiyama T,Traganos F,Darzynkiewicz Z,Sawai T

更新日期：2010-05-01 00:00:00

abstract：:Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...

journal_title：International journal of oncology

authors： Devor EJ,Gonzalez-Bosquet J,Thiel KW,Leslie KK

更新日期：2020-12-01 00:00:00

abstract：:Seven ovarian and one cervical human cancer cell lines were examined far their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and to...

journal_title：International journal of oncology

authors： Aluigi M,Debernardis D,Cimoli G,Ottoboni C,Parodi S,Russo P

更新日期：1995-09-01 00:00:00

abstract：:Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune res...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：2015-12-01 00:00:00