Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest.

abstract：:A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the eff...

journal_title：International journal of oncology

authors： Chiao JW,Xu W,Yang YM,Kancherla R,Seiter K,Ahmed T,Mittelman A

更新日期：1999-10-01 00:00:00

abstract：:To elucidate the involvement of proteasome inhibition in apoptosis induced by anthracycline anticancer agents, we investigated the interaction between the proteasome and anthracycline anticancer agents, and the function of the proteasome in apoptosis. Exposure of L1210 mouse lymphocytic leukemia cells to adriamycin (A...

journal_title：International journal of oncology

authors： Kiyomiya K,Kurebe M,Nakagawa H,Matsuo S

更新日期：2002-06-01 00:00:00

abstract：:Adrenomedullin (AM) is a multifunctional 52-amino acid peptide. AM has several effects and acts as a growth factor in several types of cancer cells. Our previous study revealed that an AM antagonist (AMA) suppressed the growth of pancreatic tumors in mice, although its mechanism was not elucidated. In this study, we c...

journal_title：International journal of oncology

authors： Tsuchiya K,Hida K,Hida Y,Muraki C,Ohga N,Akino T,Kondo T,Miseki T,Nakagawa K,Shindoh M,Harabayashi T,Shinohara N,Nonomura K,Kobayashi M

更新日期：2010-06-01 00:00:00

abstract：:A total of forty-one tumor infiltrating T cell lines (TIL) were cloned, in the presence of interleukin-2, from nine breast tumor and five melanoma specimens with limiting dilution in a microculture system. Nineteen (46%) of the lines/clones reacted to autologous tumor targets. The T cell receptor (TcR) V beta gene usa...

journal_title：International journal of oncology

authors： Chin Y,Janssens J,Bleus J,Vandevijver C,Zhang J,Raus J

更新日期：1995-07-01 00:00:00

abstract：:The regions upstream from the human N-myc gene were examined for both transcription and replication. The plasmids containing several N-myc regions linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to human neuroblastoma IMR32 cells. The results indicated that the region spanning fro...

journal_title：International journal of oncology

authors： Nakagawa T,Imamura Y,Iguchiariga S,Ariga H

更新日期：1994-09-01 00:00:00

abstract：:The hepatitis B virus (HBV) encodes a 16.5 kDa multifunctional protein termed pX or HBx, required for transcription of the viral genome and implicated in the development of hepatocellular carcinoma (HCC) in chronic HBV-infected patients. However, the mechanism of pX-mediated hepatocarcinogenesis remains unknown. pX is...

journal_title：International journal of oncology

authors： Andrisani OM,Barnabas S

更新日期：1999-08-01 00:00:00

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:The aim of the present study was to investigate the role of Cyclic-nucleotide Response Element-Binding (CREB) family members and related nuclear transcription factors in the radiation response of human B lymphoma cell lines (Daudi and Ramos). Unlike the more radiosensitive Daudi cells, Ramos cells demonstrated only a ...

journal_title：International journal of oncology

authors： Di Nisio C,Sancilio S,Di Giacomo V,Rapino M,Sancillo L,Genovesi D,Di Siena A,Rana RA,Cataldi A,Di Pietro R

更新日期：2016-01-01 00:00:00

abstract：:The tumor suppressor protein p53 is one of the most important manipulators of the cell cycle. By interaction with targets such as WAF1/CIP1, mdm2 or GADD45 p53 functions as a negative or positive regulator of the cell cycle. After DNA damage p53 is implicated in growth arrest of cells in the G(1) phase of the cell cyc...

journal_title：International journal of oncology

authors： Gotz C,Montenarh M

更新日期：1995-05-01 00:00:00

abstract：:Clinical trials using antiangiogenic drugs revealed their potential against cancer. Unfortunately, a large percentage of patients does not yet benefit from this therapeutic approach highlighting the need of diagnostic tools to non-invasively evaluate and monitor response to therapy. It would also allow to predict whic...

journal_title：International journal of oncology

authors： Taurone S,Galli F,Signore A,Agostinelli E,Dierckx RA,Minni A,Pucci M,Artico M

更新日期：2016-08-01 00:00:00

abstract：:We have carried out three rounds of screening tests using 239 synthetic tripeptides for the growth-inhibitory activity toward tumor cells and found that those having amino acid sequences of Pro-Thr-Trp or Glu-Arg-Pro effectively inhibit proliferation of transformed cells. These peptides could be the fundamental struct...

journal_title：International journal of oncology

authors： Hiwasa T,Soeda C,Takanohashi S,Kobayashi H,Suzuki A,Ueyama T,Ike Y

更新日期：1996-01-01 00:00:00

abstract：:The effects of prostaglandin E2 and indomethacin on carcinogenesis were studied in male Wistar rats. Of the rats, those treated with MNNG (MNNG group) were given 1 ml of 0.1% solution of MNNG in distilled water by intrarectal instillation every day for 14 days. The diet for the rats treated with Indomethacin and MNNG ...

journal_title：International journal of oncology

authors： Yamaguchi A,Goi T,Nakagawara G,Ishida T,Miyazaki I

更新日期：1993-08-01 00:00:00

abstract：:Intracellular antigens are presented to CD8+ T cells through major histocompatibility complex (MHC) class I molecule. For stable MHC class I expression, several molecules as well as the MHC molecule itself have to express simultaneously and function well. To determine a gene associated with MHC class I surface express...

journal_title：International journal of oncology

authors： Kang JK,Yoon SJ,Kim NK,Heo DS

更新日期：2000-06-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising anti-cancer agents, but some tumor types develop resistance to TRAIL. Here, we report that chetomin, an inhibitor of hypoxia-inducible factors, is a potent enhancer of TRAIL-induced apoptosis. TRAIL or chetomin alone weakly in...

journal_title：International journal of oncology

authors： Yano K,Horinaka M,Yoshida T,Yasuda T,Taniguchi H,Goda AE,Wakada M,Yoshikawa S,Nakamura T,Kawauchi A,Miki T,Sakai T

更新日期：2011-02-01 00:00:00

abstract：:p57KIP2, the second class of KIP family protein, is one of the negative regulators of the cell cycle. To elucidate the role of p57KIP2 in colorectal normal mucosa and cancer, we examined the expression of p57KIP2 protein in 110 pairs of colorectal non-tumor and cancer tissues. Immunohistochemical analysis showed that ...

journal_title：International journal of oncology

authors： Noura S,Yamamoto H,Sekimoto M,Takemasa I,Miyake Y,Ikenaga M,Matsuura N,Monden M

更新日期：2001-07-01 00:00:00

abstract：:We purified and identified eight xanthones from mangosteen (Garcinia mangostana L.) and investigated whether these compounds inhibited the activities of mammalian DNA polymerases (Pols) and human DNA topoisomerases (Topos). β-Mangostin was the strongest inhibitor of both mammalian Pols and human Topos among the isolat...

journal_title：International journal of oncology

authors： Onodera T,Takenaka Y,Kozaki S,Tanahashi T,Mizushina Y

更新日期：2016-03-01 00:00:00

abstract：:The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...

journal_title：International journal of oncology

authors： Thakkar A,Chenreddy S,Wang J,Prabhu S

更新日期：2015-04-01 00:00:00

abstract：:Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...

journal_title：International journal of oncology

authors： Yang Y,Pham CD,Arlinghaus RB,Khillan JS,Singh B

更新日期：1998-05-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) and acute myeloid leukemia are the major causes of mortality and morbidity in Fanconi anemia (FA) patients. The objective of this study was to investigate the antineoplastic activity of PB, an antineoplastic nutrient mixture (containing quercetin, curcumin, green tea, cruc...

journal_title：International journal of oncology

authors： Roomi MW,Kalinovsky T,Roomi NW,Niedzwiecki A,Rath M

更新日期：2015-05-01 00:00:00

abstract：:Human chondrosarcoma cells (HCS-TG) were transduced with the gene for a herpes simplex virus thymidine kinase (HSV-tk) or Escherichia coli beta-galactosidase (lacZ). We investigated the cytotoxicity of human chondrosarcoma bearing an HSV-tk gene after treatment with ganciclovir. Chondrosarcoma cells bearing an HSV-tk ...

journal_title：International journal of oncology

authors： Seto M,Wakabayashi H,Yamazaki T,Sonoda J,Shinto Y,Uchida A

更新日期：1999-06-01 00:00:00

abstract：:Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutation...

journal_title：International journal of oncology

authors： Furihata M,Shuin T,Takeuchi T,Sonobe H,Ohtsuki Y,Akiyama Y,Yuasa Y

更新日期：2000-03-01 00:00:00

abstract：:Serial analysis of gene expression (SAGE) is a sequence-based tool that enables quantitative study of comprehensive gene expression profiles. In this study, we generated a SAGE library of hepatitis B virus (HBV)-associated small hepatocellular carcinoma (HCC) and compared it with libraries of normal liver and other or...

journal_title：International journal of oncology

authors： Kim JW,Lee SH,Park YS,Jeong SH,Kim N,Lee DH,Lee HS

更新日期：2009-07-01 00:00:00

abstract：:The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...

journal_title：International journal of oncology

authors： Wang Q,Hao J,Pu J,Zhao L,Lü Z,Hu J,Yu Q,Wang Y,Xie Y,Li G

更新日期：2011-10-01 00:00:00

abstract：:Tetramethypyrazine (TMP), one of the active compounds extracted from the traditional Chinese medicinal herb (Chuanxiong), has been verified as an anticancer compound against several types of cancer. However, understanding of the molecular mechanisms have not been fully elucidated. In the present study, the anticancer ...

journal_title：International journal of oncology

authors： Luan Y,Liu J,Liu X,Xue X,Kong F,Sun C,Wang J,Liu L,Jia H

更新日期：2016-10-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00

abstract：:Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymi...

journal_title：International journal of oncology

authors： Nishioka K,Fujimori Y,Hashimoto-Tamaoki T,Kai S,Qiu H,Kobayashi N,Tanaka N,Westerman KA,Leboulch P,Hara H

更新日期：2003-10-01 00:00:00

abstract：:Recently, the inflammatory cytokine IL-6 has been reported as a potent inducer of epithelial-mesenchymal transition (EMT) in breast cancer cells with an epithelial phenotype. Furthermore, EMT induces stem cell features in normal and transformed mammary cells. We explored whether IL-...

journal_title：International journal of oncology

authors： Xie G,Yao Q,Liu Y,Du S,Liu A,Guo Z,Sun A,Ruan J,Chen L,Ye C,Yuan Y

更新日期：2012-04-01 00:00:00

abstract：:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotensio...

journal_title：International journal of oncology

authors： Cheung NK,Kushner BH,Yeh SD,Larson SM

更新日期：1998-06-01 00:00:00

abstract：:Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypoxia is involved in ...

journal_title：International journal of oncology

authors： Kogita A,Togashi Y,Hayashi H,Sogabe S,Terashima M,De Velasco MA,Sakai K,Fujita Y,Tomida S,Takeyama Y,Okuno K,Nakagawa K,Nishio K

更新日期：2014-10-01 00:00:00