Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.

abstract：:Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of CDC20 in hepatocellular carc...

journal_title：International journal of oncology

authors： Li J,Gao JZ,Du JL,Huang ZX,Wei LX

更新日期：2014-10-01 00:00:00

abstract：:Oncogenic, moderately immunogenic MK16/1/IIIABC (MK16) cells were previously established by co-transfection of HPV 16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of the MK16 cells produced progressively growing neoplasms which metastasized spontaneously to lungs. In t...

journal_title：International journal of oncology

authors： Mendoza L,Bubeník J,Símová J,Jandlová T,Vonka V,Mikysková R

更新日期：2003-07-01 00:00:00

abstract：:The relationship between mucin markers and several clinical and pathological characteristics was investigated in breast cancer tissue. CA549, CA15.3 and MCA were measured using commercially available assay methods in 82 primary breast carcinomas and 47 normal glandular breast tissue samples. Similarly to CA15.3 and MC...

journal_title：International journal of oncology

authors： Gion M,Plebani M,Mione R,Capitanio G,Penzo C,Meo S

更新日期：1993-10-01 00:00:00

abstract：:In normal human somatic cells, gradual shortening of telomeres may activate the complex cascade of molecular events known as cellular senescence. Experimental evidence from our laboratory suggests that cellular mortality is regulated by two separate mechanisms that we have termed mortality stage 1 (M1) and mortality s...

journal_title：International journal of oncology

authors： Shay J,Wright W,Werbin H

更新日期：1993-10-01 00:00:00

abstract：:We established a new lymphoma cell line, designated CTB-1, from pericardial effusion of a patient with diffuse large B-cell lymphoma. This cell line showing vigorous growth ability has undergone 260 passages over a period of 34 months in suspension culture, and is heterotransplantable to nude mice. The cultured cells ...

journal_title：International journal of oncology

authors： Uchida Y,Miyazawa K,Yaguchi M,Gotoh A,Iwase O,Ohyashiki K,Toyama K

更新日期：1997-06-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:One of the genes that the authors have isolated by a differential display of hepatocellular carcinoma compared to adjacent liver is the alpha6 integrin. alpha6 integrin is the major adhesion receptor for laminin and is suggested to be involved in tumor cell invasion and metastasis. To our knowledge, however, there are...

journal_title：International journal of oncology

authors： Tanaka Y,Mimori K,Shiraishi T,Ohkura Y,Takubo K,Mafune K,Barnard GF,Mori M

更新日期：2000-04-01 00:00:00

abstract：:MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream...

journal_title：International journal of oncology

authors： Zhang H,Feng Z,Huang R,Xia Z,Xiang G,Zhang J

更新日期：2014-11-01 00:00:00

abstract：:One hundred and eighty-one breast cancer specimens were analyzed for nuclear p53 staining by immunochemical methods. There were 123 fine-needle cytological specimens and 58 frozen tissue sections of surgical biopsies. The microscopic evaluation of the staining fitted with a 4 group classification. Ninety-one samples (...

journal_title：International journal of oncology

authors： Lesec G,Richardcoulet E,Collet J,Demaublanc M,Merle S,Salmon R,Remvikos Y

更新日期：1997-04-01 00:00:00

abstract：:Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...

journal_title：International journal of oncology

authors： Nozaki Y,Isobe K,Nakashima I,Shimokata K

更新日期：1993-06-01 00:00:00

abstract：:We investigated the relationship between cell growth and differentiation and COX-2 expression in oral squamous cell carcinoma (SCC) in vitro and in vivo. Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and in...

journal_title：International journal of oncology

authors： Kuroda J,Urade M,Kishimoto H,Noguchi K,Hashitani S,Sakurai K,Nishimura N,Hashimoto-Tamaoki T

更新日期：2005-02-01 00:00:00

abstract：:Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...

journal_title：International journal of oncology

authors： Thews O,Lambert C,Kelleher DK,Biesalski HK,Vaupel P,Frank J

更新日期：2005-09-01 00:00:00

abstract：:We have recently demonstrated in a mouse renal adenocarcinoma tumor system that the antitumor effect of adriamycin (ADM) in combination with interleukin-2 (IL2) is superior to treatment with either ADM or IL2 alone. Based on this observation we postulated that modulation of host's immune competence by ADM and/or IL2 m...

journal_title：International journal of oncology

authors： Gautam S,Chikkala N,Ganapathi R

更新日期：1992-12-01 00:00:00

abstract：:To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...

journal_title：International journal of oncology

authors： Kohnoe S,Maehara Y,Takahashi I,Yoshida M,Emi Y,Baba H,Sugimachi K

更新日期：1993-11-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with liver metastases are candidates for potentially curative surgical resection. The treatment of patients with unresectable liver tumors is a major clinical probl...

journal_title：International journal of oncology

authors： Cai SR,Garbow JR,Culverhouse R,Church RD,Zhang W,Shannon WD,McLeod HL

更新日期：2005-07-01 00:00:00

abstract：:With a view to identifying markers reflecting not the evidence of, but the potential for, neoplastic progression of the breast we have compared the normal invasive mammary epithelial cell growth seen at puberty with invasive and non-invasive carcinogenesis using the mouse as a model. We have analyzed cell proliferatio...

journal_title：International journal of oncology

authors： Djonov V,Altermatt H,Arnold A,Gerber H,Andres A

更新日期：1995-08-01 00:00:00

abstract：:Patients with pancreatic cancer frequently demonstrate symptoms such as weight-loss and muscle wasting and have clinical evidence of a systemic inflammatory response. Such effects may be mediated by pro-inflammatory cytokines derived from tumor cells. The production of interleukin-6 and -8 by pancreatic cancer cell li...

journal_title：International journal of oncology

authors： Wigmore SJ,Fearon KC,Sangster K,Maingay JP,Garden OJ,Ross JA

更新日期：2002-10-01 00:00:00

abstract：:Over the past few decades, there has been a tremendous increase in cancer biology data and treatment. Cancer research has opened exciting new areas of cellular and molecular biology. Month by month, new genes which regulate the carcinogenesis process are being discovered. The result is an incredible knowledge of cance...

journal_title：International journal of oncology

authors： Kanduc D,Bannasch P,Farber E

更新日期：1999-12-01 00:00:00

abstract：:The overall goal of the present study was to evaluate the chemotherapeutic and cancer‑protective properties of D‑erythro‑sphingosine (sphingosine) and C2‑ceramide using a human breast epithelial cell (HBEC) culture system, which represents multiple‑stages of breast carcinogenesis. The HBEC model includes Type I HBECs ...

journal_title：International journal of oncology

authors： Ahn EH,Yang H,Hsieh CY,Sun W,Chang CC,Schroeder JJ

更新日期：2019-02-01 00:00:00

abstract：:Chromosomal alterations are a major genomic force contributing to the development of lung cancer. We subjected 22 cases of squamous cell carcinoma of the lung (SCC) to whole-genome microarray-CGH (resolution, 1 Mb) to identify critical genetic landmarks that might be important mediators in the formation or progression...

journal_title：International journal of oncology

authors： Kang JU,Koo SH,Kwon KC,Park JW

更新日期：2010-08-01 00:00:00

abstract：:The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...

journal_title：International journal of oncology

authors： Chen WJ,Xiong ZA,Zhang M,Yao CG,Zhao ZY,Hua YY,Zhou W

更新日期：2013-03-01 00:00:00

abstract：:Liver cancer is the fourth leading cause of cancer‑related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2 (PIM2), has been shown to be overexpressed in liver cancer, ...

journal_title：International journal of oncology

authors： Kronschnabl P,Grünweller A,Hartmann RK,Aigner A,Weirauch U

更新日期：2020-02-01 00:00:00

abstract：:The tumour suppressor gene hypermethylated in cancer 1 (HIC1) is a transcriptional repressor, which functionally cooperates with p53. Loss of HIC1 function is associated with the development of various tumor entities. The aim of this study was to elucidate the relevance of CpG islan...

journal_title：International journal of oncology

authors： Eggers H,Steffens S,Grosshennig A,Becker JU,Hennenlotter J,Stenzl A,Merseburger AS,Kuczyk MA,Serth J

更新日期：2012-05-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...

journal_title：International journal of oncology

authors： Liu J,Zhai R,Zhao J,Kong F,Wang J,Jiang W,Xin Q,Xue X,Luan Y

更新日期：2018-05-01 00:00:00

abstract：:Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...

journal_title：International journal of oncology

authors： Tennstedt P,Köster P,Brüchmann A,Mirlacher M,Haese A,Steuber T,Sauter G,Huland H,Graefen M,Schlomm T,Minner S,Simon R

更新日期：2012-01-01 00:00:00

abstract：:Hexadecylphosphocholine (HPC, D-18506, INN: Miltefosine) was characterized in a clonogenic micro assay in vitro with respect to its cytotoxicity against a panel of human and murine tumor cell lines and murine bone marrow cultures (GM-CFC). The KB human epithelial carcinoma line was found to be more sensitive by at lea...

journal_title：International journal of oncology

authors： Voegeli R,Echarti C,Maurer H,Stekar J,Hilgard P,Unger C

更新日期：1993-02-01 00:00:00

abstract：:Frizzled (FZD) genes encode receptors for WNTs, which play key roles in carcinogenesis and embryogenesis. We have previously cloned the FZD10 gene, and demonstrated up-regulation of FZD10 mRNA in the cervical cancer cell line HeLa S3, gastric cancer cell lines TMK1 and MKN74, and 4 cases out of 10 cases of primary gas...

journal_title：International journal of oncology

authors： Saitoh T,Mine T,Katoh M

更新日期：2002-01-01 00:00:00

abstract：:Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...

journal_title：International journal of oncology

authors： Narayanan R,Kim HN,Narayanan NK,Nargi D,Narayanan B

更新日期：2012-01-01 00:00:00