Implication of new figo surgical staging on patterns of failure and survival in endometrial carcinoma.

abstract：:The p16INK4 gene, encoding a cyclin-dependent kinase inhibitor, is frequently methylated in colorectal cancer, and a side-specific methylation frequency was suggested. To clarify the frequency of real loss of tumor suppressor function dependent on anatomical localization, we investigated 43 primary colorectal carcinom...

journal_title：International journal of oncology

authors： Schneider-Stock R,Boltze C,Peters B,Höpfner T,Meyer F,Lippert H,Roessner A

更新日期：2003-10-01 00:00:00

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:Although most hepatocellular carcinoma (HCC) is related to viral infection, there is a substantial population of HCC patients (5-20%) who are negative for both markers of hepatitis B virus and hepatitis C virus infection [non-B, non-C (NBNC) hepatitis] in Japan and the incidence of NBNC-HCC has recently tended to incr...

journal_title：International journal of oncology

authors： Nishikawa H,Osaki Y

更新日期：2013-11-01 00:00:00

abstract：:The present study shows that an application of cyclophosphamide (CY) supported by dendritic cell (DC)-based vaccines affected differentiation of the activity of CD4+ T cell subpopulations accompanied by an alteration in CD8+ cell number. Vaccines were composed of bone marrow-derived DCs activated with tumor cell lysat...

journal_title：International journal of oncology

authors： Wojas-Turek J,Szczygieł A,Kicielińska J,Rossowska J,Piasecki E,Pajtasz-Piasecka E

更新日期：2016-02-01 00:00:00

abstract：:Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not wel...

journal_title：International journal of oncology

authors： Borrego-Diaz E,Powers BC,Azizov V,Lovell S,Reyes R,Chapman B,Tawfik O,McGregor D,Diaz FJ,Wang X,Veldhuizen PV

更新日期：2014-12-01 00:00:00

abstract：:Chemo- and radiotherapy induce apoptosis in tumours and surrounding tissues. In a search for robust and reliable apoptosis markers, we have evaluated immunostaining patterns of gammaH2AX and cleaved PARP-1 in paraffin-embedded cellular spheroids. Breast cancer BT474 cells were grown as cell spheroids to diameters of 7...

journal_title：International journal of oncology

authors： Qvarnström OF,Simonsson M,Eriksson V,Turesson I,Carlsson J

更新日期：2009-07-01 00:00:00

abstract：:The gp160 human kidney differentiation antigen is identical to human aminopeptidase A (APA), a zinc-dependent cell-surface metallopeptidase which hydrolyzes peptides with N-terminal acidic residues. GP160/APA is constitutively expressed by proximal tubule cells, the normal cellular counterpart of most renal cancers (R...

journal_title：International journal of oncology

authors： Nanus DM,Bogenrieder T,Papandreou CN,Finstad CL,Lee A,Vlamis V,Motzer RJ,Bander NH,Albino AP,Reuter VE

更新日期：1998-08-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target for anticancer drug design. However, few reports have described the constitutive activation of STAT3 in human sarcoma cells. In this study, we demonstrate that t...

journal_title：International journal of oncology

authors： Wei CC,Ball S,Lin L,Liu A,Fuchs JR,Li PK,Li C,Lin J

更新日期：2011-01-01 00:00:00

abstract：:A consecutive series of 118 samples from patients referred to colposcopy assessment and follow-up with cytology and biopsies were analysed with immunocytochemical staining to determinate the expression of p16(INK4a). Accumulation of p16(INK4a) antigen has been proposed as a biomarker helpful for the identification of ...

journal_title：International journal of oncology

authors： Norman I,Brismar S,Zhu J,Gaberi V,Hagmar B,Hjerpe A,Andersson S

更新日期：2007-12-01 00:00:00

abstract：:Hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC) is a global health problem that accounts for more than half of total liver cancer cases in developing countries. Despite the growing number of researches conducted, the molecular mechanism underlying the development of HCC remains elusive. Long non‑coding ...

journal_title：International journal of oncology

authors： Zhang H,Chen X,Zhang J,Wang X,Chen H,Liu L,Liu S

更新日期：2020-01-01 00:00:00

abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

journal_title：International journal of oncology

authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

更新日期：2006-01-01 00:00:00

abstract：:Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...

journal_title：International journal of oncology

authors： Choi EO,Park C,Hwang HJ,Hong SH,Kim GY,Cho EJ,Kim WJ,Choi YH

更新日期：2016-09-01 00:00:00

abstract：:Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. We have previously reported that HBXIP promotes the proliferation and migration of breast cancer cells. S-phase kinase-associated protein 2 (Skp2) is another oncoprotein which is important for migration. In this study, we investigated whether Skp2 is in...

journal_title：International journal of oncology

authors： Xu F,Zhu X,Han T,You X,Liu F,Ye L,Zhang X,Wang X,Yao Y

更新日期：2014-07-01 00:00:00

abstract：:Primary hyperparathyroidism is a common endocrine disease with a multifaceted genetic background, the elucidation of which has only begun. Among others, loss of the short arm of chromosome 1 and somatic inactivation of the multiple endocrine neoplasia type 1 gene (MEN1) in 11q13 represent significant alterations in th...

journal_title：International journal of oncology

authors： Välimäki S,Forsberg L,Farnebo LO,Larsson C

更新日期：2002-10-01 00:00:00

abstract：:A group of 133 primary oral squamous cell carcinomas were studied concerning a relationship between exposure factors and tumour biological parameters with a focus on the TP53 gene and p53 protein status. Tumours were evaluated using immunohistochemistry (IHC) for expression of p53, PCNA, Ki-67 and bcl-2 proteins. The ...

journal_title：International journal of oncology

authors： Schildt EB,Nylander K,Eriksson M,Hardell L,Magnusson A,Roos G

更新日期：2003-04-01 00:00:00

abstract：:Claudin 6 (CLDN6), a member of tight junction protein claudin (CLDN) family, inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. However, these molecular mechanisms of CLDN6-induced apoptosis remain largely elusive. We previously found that restoration of human CLDN6 gene expression was correlat...

journal_title：International journal of oncology

authors： Guo Y,Lin D,Zhang M,Zhang X,Li Y,Yang R,Lu Y,Jin X,Yang M,Wang M,Zhao S,Quan C

更新日期：2016-06-01 00:00:00

abstract：:A slowly proliferating cell fraction in tumors shows reduced sensitivity to cell cycle-dependent anticancer agents. To understand the molecular basis of drug resistance observed in brain tumors, we examined the relationship between alteration of p16, a cyclin dependent kinase inhibitor whose functions are frequently l...

journal_title：International journal of oncology

authors： Iwadate Y,Mochizuki S,Fujimoto S,Namba H,Sakiyama S,Tagawa M,Yamaura A

更新日期：2000-09-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:Cancer antigens RAK-p120, p42, and p25, which exhibit biological, immunological and molecular similarity to the proteins expressed by Human Immunodeficiency Virus 1 (HIV-1), were found in 47 of 47 tested cases of serous adenocarcinoma of the ovary, and 45 of 45 tested cases of squamous carcinoma of the cervix. Normal ...

journal_title：International journal of oncology

authors： Rakowiczszulczynska E,Roszak A,Mackiewicz A,Markowska J,McIntosh D,Karczewska A,Godlewski D,Snyder W,Leary D,Smith M

更新日期：1996-10-01 00:00:00

abstract：:Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vecto...

journal_title：International journal of oncology

authors： Yamanaka R

更新日期：2004-04-01 00:00:00

abstract：:After the publication of the article, the authors noted that they had made the following errors. In Fig. 5B, total PDK1 is incorrect in the published paper. The corrected version of Fig. 5B is shown below. Also in Fig. 6B, the DMSO-treated group and the brassinin (400 µM)-treated group are incorrect, and the corrected...

journal_title：International journal of oncology

authors： Izutani Y,Yogosawa S,Sowa Y,Sakai T

更新日期：2016-03-01 00:00:00

abstract：:The effects of a thymic peptide preparation (TP) on the immunocytotoxicity and cytokine secretion of peripheral blood lymphocytes and monocytes from patients with colorectal tumors, breast tumors and melanoma were studied in vitro. On average, breast tumor and melanoma patients showed significantly lower natural kille...

journal_title：International journal of oncology

authors： Eckert K,Mayer G,Stange R,Kalden M,Krasagakis K,Maurer H

更新日期：1997-03-01 00:00:00

abstract：:Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer. Anti-cancer effects are due to the virus ability: i) to replicate in and kill tumor cells, leading finally to their selective elimination; and ...

journal_title：International journal of oncology

authors： Fournier P,Wilden H,Schirrmacher V

更新日期：2012-01-01 00:00:00

abstract：:Activation of intestinal human pregnane X receptor (PXR) has recently been proposed as a promising strategy for the chemoprevention of inflammation-induced colon cancer. The present study was aimed at evaluating the effect of rifaximin, a non-absorbable antibiotic, in inhibiting angiogenesis in a model of human colore...

journal_title：International journal of oncology

authors： Esposito G,Gigli S,Seguella L,Nobile N,D'Alessandro A,Pesce M,Capoccia E,Steardo L,Cirillo C,Cuomo R,Sarnelli G

更新日期：2016-08-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...

journal_title：International journal of oncology

authors： Otsuki T,Fujimoto D,Hirono Y,Goi T,Yamaguchi A

更新日期：2014-12-01 00:00:00

abstract：:Transcriptional silencing of the DNA repair protein, O6-methylguanine-DNA methyltransferase (MGMT), occurs only in malignant or transformed cell lines, and such MGMT-deficient cells are hypersensitive to chemotherapeutic alkylating agents such as 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide. Previous...

journal_title：International journal of oncology

authors： Danam RP,Howell SR,Remack JS,Brent TP

更新日期：2001-06-01 00:00:00

abstract：:Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...

journal_title：International journal of oncology

authors： Kijima H,Yamazaki H,Nakamura M,Scanlon KJ,Osamura RY,Ueyama Y

更新日期：2004-03-01 00:00:00

abstract：:Lymphoid hyperplasia of lacrimal gland may be difficult to be differentiated from lymphomas on the basis of morphology and immunohistochemistry. The results of this study indicate that polymerase chain reaction should be employed for confirming the diagnosis of lymphoma in cases with histological and immunophenotypica...

journal_title：International journal of oncology

authors： Leoncini L,Funto I,Lazzi S,Pacenti L,Polito E,Bartolomei A,Leccisotti A,Cintorino M,Tosi P

更新日期：1993-11-01 00:00:00

abstract：:Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7...

journal_title：International journal of oncology

authors： Kirikoshi H,Sekihara H,Katoh M

更新日期：2001-07-01 00:00:00

abstract：:It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...

journal_title：International journal of oncology

authors： Katiyar SK

更新日期：2002-12-01 00:00:00