Diagnostic evaluation of cancer antigens RAK .1. Cervical and ovarian cancer.

abstract：:The effects of a thymic peptide preparation (TP) on the immunocytotoxicity and cytokine secretion of peripheral blood lymphocytes and monocytes from patients with colorectal tumors, breast tumors and melanoma were studied in vitro. On average, breast tumor and melanoma patients showed significantly lower natural kille...

journal_title：International journal of oncology

authors： Eckert K,Mayer G,Stange R,Kalden M,Krasagakis K,Maurer H

更新日期：1997-03-01 00:00:00

abstract：:Patients who have inoperable lung cancer usually undergo chemotherapy and have problems such as a resistance against chemotherapeutic agents during the treatment. Glutathione S-transferase (GST) is one of the detoxication-related enzymes. We studied the relationship between immunohisto-chemical staining of GST-pi type...

journal_title：International journal of oncology

authors： Arai T,Yasuda Y,Takaya T,Yoshimi N,Ito H,Fujiwara H

更新日期：1997-07-01 00:00:00

abstract：:There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the risk of breast cancer with respect to circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding...

journal_title：International journal of oncology

authors： Kahán Z,Gardi J,Nyári T,Földesi I,Hajnal-Papp R,Ormándi K,Lázár G,Thurzó L,Schally AV

更新日期：2006-07-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present work is to investigate whether microtubule-affecting drugs including vincristine, vinblastine, vindesine and vinorelbine are able to produce an anti-angiogenic effect at non-cytotoxic doses in the same way of taxol. The cytotoxic effects were determined by means of the colorimetric MTT assay, an...

journal_title：International journal of oncology

authors： Hayot C,Farinelle S,De Decker R,Decaestecker C,Darro F,Kiss R,Van Damme M

更新日期：2002-08-01 00:00:00

abstract：:Observational, clinical and experimental studies have suggested that dietary supplementation with selenium can inhibit the development of colon cancer. Since toxicity and chemopreventive efficacy of selenium compounds depend to a large extent, on the form of selenium the development of efficacious organoselenium compo...

journal_title：International journal of oncology

authors： Kawamori T,El-Bayoumy K,Ji BY,Rodriguez JG,Rao CV,Reddy BS

更新日期：1998-07-01 00:00:00

abstract：:Mutations in p53 are the most common genetic abnormality in cancers. Arsenic trioxide (ATO) is an effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia (APL) and is being tested in phase II studies in various types of cancers. We have shown that ATO is a potent inducer of apoptosis in mult...

journal_title：International journal of oncology

authors： Kircelli F,Akay C,Gazitt Y

更新日期：2007-04-01 00:00:00

abstract：:The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carc...

journal_title：International journal of oncology

authors： Zhou X,Zimonjic DB,Park SW,Yang XY,Durkin ME,Popescu NC

更新日期：2008-06-01 00:00:00

abstract：:Hypoxia, a common phenomenon during the development of malignant solid tumors including breast cancer, serves to propagate a cascade of molecular pathways triggered by hypoxia-inducible factor-1α (HIF-1α). Carbonic anhydrase IX (CA IX), one of the target genes of HIF-1α, has been reported to be involved in progression...

journal_title：International journal of oncology

authors： Chu CY,Jin YT,Zhang W,Yu J,Yang HP,Wang HY,Zhang ZJ,Liu XP,Zou Q

更新日期：2016-01-01 00:00:00

abstract：:We examined the gene expression profiles of esophageal squamous cell carcinomas (ESCCs) with respect to degree of invasive depth and lymph node (LN) involvement in a large cohort. We used high-density oligonucleotide microarrays to examine the expression of 22,115 genes in 54 ESCCs and 11 non-cancerous esophageal tiss...

journal_title：International journal of oncology

authors： Sato T,Iizuka N,Hamamoto Y,Yoshino S,Abe T,Takeda S,Uchimura S,Miyamoto T,Sei F,Hamada K,Yamada-Okabe H,Oka M

更新日期：2006-05-01 00:00:00

abstract：:Trophoblasts are derived from the normal placenta, and they infiltrate into the endometrium and the maternal blood vessels under strict control but, unlike malignant cells, never metastasize. To understand the proliferative characteristics of trophoblasts and its related disorders, we assessed telomerase activity in c...

journal_title：International journal of oncology

authors： Nishi H,Yahata N,Ohyashiki K,Isaka K,Shiraishi K,Ohyashiki JH,Toyama K,Takayama M

更新日期：1998-01-01 00:00:00

abstract：:Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of patients presenting with advanced disease will remain resistant to therapy. One of the major contributing factors in resistance to the...

journal_title：International journal of oncology

authors： Patsos HA,Greenhough A,Hicks DJ,Al Kharusi M,Collard TJ,Lane JD,Paraskeva C,Williams AC

更新日期：2010-07-01 00:00:00

abstract：:Modulation of gene expression through histone deacetylase (HDAC) inhibition is considered a possible therapeutic strategy in acute myeloid leukaemia (AML). In vitro effects and basal gene expression of structurally different HDAC inhibitors were examined. Primary human AML cells were derived from 59 consecutive patien...

journal_title：International journal of oncology

authors： Stapnes C,Ryningen A,Hatfield K,Øyan AM,Eide GE,Corbascio M,Kalland KH,Gjertsen BT,Bruserud Ø

更新日期：2007-12-01 00:00:00

abstract：:Lumican is a member of the small leucine-rich proteoglycan (SLRP) family and participates in the maintenance of tissue structures and tumor growth. Neuroendocrine cell tumors (NETs) including carcinoid tumors and NE cell carcinomas (NECs) possess numerous neuroendocrine (NE) granules, and differences between these tum...

journal_title：International journal of oncology

authors： Shinji S,Tajiri T,Ishiwata T,Seya T,Tanaka N,Naito Z

更新日期：2005-04-01 00:00:00

abstract：:Cholangiocarcinoma is the most common biliary duct malignancy and the second most common primary liver cancer, accounting for 10‑20% of hepatic malignancies. With high mortality and poor prognosis, the 5‑year survival rate of cholangiocarcinoma is only 10%. A previous study demonstrated a significant association betwe...

journal_title：International journal of oncology

authors： Shi T,Gong J,Fujita K,Nishiyama N,Iwama H,Liu S,Nakahara M,Yoneyama H,Morishita A,Nonura T,Kobara H,Okano K,Suzuki Y,Masaki T

更新日期：2020-12-30 00:00:00

abstract：:Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...

journal_title：International journal of oncology

authors： Ciatto S,Cataliotti L,Pacini P,Distante V,Bianchi S,Simoncini R,Cardona G,Rontini M,Falli F,Elbetti C

更新日期：1993-08-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome that is the main cause of inherited clear-cell renal cell carcinoma (ccRCC), which generally occurs in the form of multiple recurrent synchronized tumors. Affected patients are carriers of a germline mutation in the VHL tumor suppressor gene. Somati...

journal_title：International journal of oncology

authors： Gattolliat CH,Couvé S,Meurice G,Oréar C,Droin N,Chiquet M,Ferlicot S,Verkarre V,Vasiliu V,Molinié V,Méjean A,Dessen P,Giraud S,Bressac-De-Paillerets B,Gardie B,Tean Teh B,Richard S,Gad S

更新日期：2018-10-01 00:00:00

abstract：:To determine the tissue specificity of the potential mutations in DNA polymerase beta (pol beta), alterations in the pol beta were examined in breast, prostate, and colorectal primary tumors. The pol beta is known to contribute to mammalian base excision repair and replication. Similar to colorectal cancer, a high occ...

journal_title：International journal of oncology

authors： Wang L,Banerjee S

更新日期：1995-02-01 00:00:00

abstract：:Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...

journal_title：International journal of oncology

authors： Rieger C,Huebner D,Temme A,Wirth MP,Fuessel S

更新日期：2015-09-01 00:00:00

abstract：:WNT signaling pathway plays a key role in carcinogenesis and embryogenesis. We have cloned and characterized the human WNT5B. Overlapping WNT5B cDNAs, containing 1080-bp ORF, were isolated. WNT5B encoded a 359-amino-acid polypeptide with the N-terminal signal peptide, four N-linked glycosylation sites, and consensus a...

journal_title：International journal of oncology

authors： Saitoh T,Katoh M

更新日期：2001-08-01 00:00:00

abstract：:Cancer cells genetically modified to secrete immunoregulatory cytokines offer great promise for human cancer treatment as tumor vaccines. However, in preclinical animal studies, large established cancer burdens have appeared difficult to eradicate with such vaccines. For example, lethally-irradiated GM-CSF-secreting C...

journal_title：International journal of oncology

authors： Nigam A,Yacavone RF,Zahurak ML,Johns CM,Pardoll DM,Piantadosi S,Levitsky HI,Nelson WG

更新日期：1998-01-01 00:00:00

abstract：:Chemotherapy (CT) resistance in ovarian cancer is related to multiple factors, and assessment of these factors is necessary for the development of new drugs and therapeutic regimens. In an effort to identify such determinants, we evaluated the expression of approximately 21,000 genes using DNA microarray screening in ...

journal_title：International journal of oncology

authors： L'Espérance S,Popa I,Bachvarova M,Plante M,Patten N,Wu L,Têtu B,Bachvarov D

更新日期：2006-07-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC), the most common esophageal cancer in East Asia, is among the six cancers with the highest fatality rates worldwide. Unfortunately, multidisciplinary treatment strategies have not achieved satisfactory outcomes. Therefore, novel insights into the molecular biology of ESCC are ...

journal_title：International journal of oncology

authors： Tanaka H,Kanda M,Koike M,Iwata N,Shimizu D,Ezaka K,Sueoka S,Tanaka Y,Takami H,Hashimoto R,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Fujiwara M,Kodera Y

更新日期：2015-11-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...

journal_title：International journal of oncology

authors： Hossain MA,Kim DH,Jang JY,Kang YJ,Yoon JH,Moon JO,Chung HY,Kim GY,Choi YH,Copple BL,Kim ND

更新日期：2012-04-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：International journal of oncology

authors： Navolanic PM,McCubrey JA

更新日期：2005-11-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of lysyl oxidase‑like 2 (LOXL2) on the invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of renal cell carcinoma (RCC) cells through the steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway. RCC tissues and adjacen...

journal_title：International journal of oncology

authors： Hong X,Yu JJ

更新日期：2019-05-01 00:00:00

abstract：:It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...

journal_title：International journal of oncology

authors： Katiyar SK

更新日期：2002-12-01 00:00:00

abstract：:Women from ethnic minority groups, including immigrants and refugees are reported to have low breast cancer (BC) screening rates. Active, culturally-sensitive outreach is vital for increasing participation of these women in BC screening programs. Women at high BC risk and who belong to an ethnic minority group are of ...

journal_title：International journal of oncology

authors： Belkić K,Cohen M,Wilczek B,Andersson S,Berman AH,Márquez M,Vukojević V,Mints M

更新日期：2015-09-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that transmits signals through G-protein-coupled receptors to control cellular differentiation, survival, and several functions of immune cells. S1P is a chemoattractant for NK cells, which are critical members of the immunological tumor surveillance machinery....

journal_title：International journal of oncology

authors： Lagadari M,Lehmann K,Ziemer M,Truta-Feles K,Berod L,Idzko M,Barz D,Kamradt T,Maghazachi AA,Norgauer J

更新日期：2009-01-01 00:00:00

abstract：:Thirty patients who underwent hepatectomy for the treatment of hepatocellular carcinoma (HCC) were examined for expression of HLA class I antigens on HCC cells by flow cytometry. The expression was found significantly lower in cases of stage IV compared with those of stage I or stage II (p<0.05), and in cases of intra...

journal_title：International journal of oncology

authors： Nishibe M,Une Y,Kobayashi M,Kuramitsu Y,Hosokawa M,Uchino J

更新日期：1996-06-01 00:00:00