Abstract:
:Trophoblasts are derived from the normal placenta, and they infiltrate into the endometrium and the maternal blood vessels under strict control but, unlike malignant cells, never metastasize. To understand the proliferative characteristics of trophoblasts and its related disorders, we assessed telomerase activity in chorionic villi obtained from 27 normal individuals, 9 hydatidiform moles, and 2 choriocarcinomas. Telomerase activity was detected in 13/27 (48%) normal chorionic villi samples. The detectability and the level of telomerase activity depended on gestational age; 8/10 (80%) villi samples in the first trimester (relative telomerase activity; 1.77 +/- 1.37), whereas 2/8 (25%) villi samples in the second trimester (0.78 +/- 1.52) and 3/9 (33%) in the third trimester (0.28 +/- 0.43) had telomerase activity. Telomerase activity of normal chorionic villi in the first trimester was higher than that of the third trimester (P = 0.0251). In contrast, all mole samples had increased telomerase activity compared to normal villi (3.17 +/- 2.81, P = 0.0152). Thus, a relationship may exist among cell proliferation, telomerase activity, and progression to trophoblastic disease.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Nishi H,Yahata N,Ohyashiki K,Isaka K,Shiraishi K,Ohyashiki JH,Toyama K,Takayama Mdoi
10.3892/ijo.12.1.81subject
Has Abstractpub_date
1998-01-01 00:00:00pages
81-5issue
1eissn
1019-6439issn
1791-2423journal_volume
12pub_type
杂志文章abstract::Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...
journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:2019-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.6.1203
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.12.5.1137
更新日期:1998-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1105
更新日期:2011-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.5.959
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journal_title:International journal of oncology
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更新日期:2006-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 已发布勘误
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更新日期:1997-05-01 00:00:00
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更新日期:2016-02-01 00:00:00