NJK14013, a novel synthetic estrogen receptor-α agonist, exhibits estrogen receptor-independent, tumor cell-specific cytotoxicity.

abstract：:To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...

journal_title：International journal of oncology

authors： Kohnoe S,Maehara Y,Takahashi I,Yoshida M,Emi Y,Baba H,Sugimachi K

更新日期：1993-11-01 00:00:00

abstract：:Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at...

journal_title：International journal of oncology

authors： Kisu I,Banno K,Kobayashi Y,Ono A,Masuda K,Ueki A,Nomura H,Hirasawa A,Abe T,Kouyama K,Susumu N,Aoki D

更新日期：2011-11-01 00:00:00

abstract：:Emerging evidence indicates that mesenchymal stem cells (MSCs) serve an indispensable role in the tumor microenvironment. However, whether MSCs participate in the development of oral carcinogenesis remains unclear. The present study isolated MSCs from clinical tissues and investigated the differences of MSCs derived f...

journal_title：International journal of oncology

authors： Li W,Han Y,Zhao Z,Ji X,Wang X,Jin J,Wang Q,Guo X,Cheng Z,Lu M,Wang G,Wang Y,Liu H

更新日期：2019-05-01 00:00:00

abstract：:In the multistep progressive pathogenesis of human breast cancer, comedo ductal carcinoma in situ (DCIS) represents a preinvasive precursor lesion for therapy resistant invasive cancer. Human tissue derived cell culture models exhibiting molecular similarities to clinical DCIS facilitate an important preclinical mecha...

journal_title：International journal of oncology

authors： Katdare M,Osborne M,Telang NT

更新日期：2002-10-01 00:00:00

abstract：:We hypothesize that dysregulated expression levels of the developmental regulatory genes in the adult body result in tumor development and malignant progression. PAX genes discovered as human orthologous genes of Drosophila 'paired' encode transcription factors, which control the expression of target genes to go on al...

journal_title：International journal of oncology

authors： Hata S,Hamada J,Maeda K,Murai T,Tada M,Furukawa H,Tsutsumida A,Saito A,Yamamoto Y,Moriuchi T

更新日期：2008-11-01 00:00:00

abstract：:Advanced metastatic melanoma is a malignant tumor for which there is currently no effective treatment due to resistance development. Ginsenoside Rg3, a saponin component extracted from ginseng roots, has been shown to reduce melanoma cell proliferation by decreasing histone deacetylase 3 and increasing p53 acetylation...

journal_title：International journal of oncology

authors： Meng L,Ji R,Dong X,Xu X,Xin Y,Jiang X

更新日期：2019-06-01 00:00:00

abstract：:Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...

journal_title：International journal of oncology

authors： Brito AF,Abrantes AM,Teixo R,Pires AS,Ribeiro AC,Ferreira RF,Mascarenhas A,Puga T,Laranjo M,Caramelo F,Boin I,Jefferson DM,Gonçalves C,Martins R,Tavares I,Ribeiro IP,Sarmento-Ribeiro AB,Carreira IM,Souza D,Tralhão J

更新日期：2020-03-01 00:00:00

abstract：:Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many types of cell lines and tissues have demonstrated the presence of SP cells, including colon cancer cell lines. This study aimed to identify cancer stem cells (CSCs) in the SP of the colon cancer cell line SW480. SP c...

journal_title：International journal of oncology

authors： Xiong B,Ma L,Hu X,Zhang C,Cheng Y

更新日期：2014-09-01 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 ...

journal_title：International journal of oncology

authors： Liu L,Yang L,Chang H,Chen YN,Zhang F,Feng S,Peng J,Ren CC,Zhang XA

更新日期：2019-03-01 00:00:00

abstract：:Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a s...

journal_title：International journal of oncology

authors： Choi YM,An S,Lee EM,Kim K,Choi SJ,Kim JS,Jang HH,An IS,Bae S

更新日期：2012-07-01 00:00:00

abstract：:NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...

journal_title：International journal of oncology

authors： Maruyama K,Tsukada T,Ohkura N,Bandoh S,Hosono T,Yamaguchi K

更新日期：1998-06-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...

journal_title：International journal of oncology

authors： Chen J,Schmitt A,Giannopoulos K,Chen B,Rojewski M,Döhner H,Bunjes D,Schmitt M

更新日期：2007-11-01 00:00:00

abstract：:Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnost...

journal_title：International journal of oncology

authors： Lee BK,Diebel E,Neukam FW,Wiltfang J,Ries J

更新日期：2001-11-01 00:00:00

abstract：:Induction chemotherapy provides an excellent model for evaluation of potential predictive factors. We studied expression of SBR grade, estrogen (ER) and progesterone (PR) receptors, HER2, Ki67 and P53 on core biopsies before and after chemotherapy in a series of 115 patients, who received anthracycline-based induction...

journal_title：International journal of oncology

authors： Penault-Llorca F,Cayre A,Bouchet Mishellany F,Amat S,Feillel V,Le Bouedec G,Ferrière JP,De Latour M,Chollet P

更新日期：2003-06-01 00:00:00

abstract：:Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...

journal_title：International journal of oncology

authors： Nestal De Moraes G,Pereira Castro C,Salustiano EJ,Dumas ML,Costas F,Wing-Fai Lam E,Ribeiro Costa PR,Maia RC

更新日期：2019-12-01 00:00:00

abstract：:The deregulation of the epidermal growth factor receptor (EGFR) pathway plays a major role in the pathogenesis of prostate cancer (PCa). However, therapies targeting EGFR have demonstrated limited effectiveness in PCa. A potential mechanism to overcome EGFR blockade in cancer cells is the autocrine activation of alter...

journal_title：International journal of oncology

authors： Carrión-Salip D,Panosa C,Menendez JA,Puig T,Oliveras G,Pandiella A,De Llorens R,Massaguer A

更新日期：2012-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of lysyl oxidase‑like 2 (LOXL2) on the invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of renal cell carcinoma (RCC) cells through the steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway. RCC tissues and adjacen...

journal_title：International journal of oncology

authors： Hong X,Yu JJ

更新日期：2019-05-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy-based gastric carcinoma (GC) treatments, hence, biologically based therapies are urgently needed. Gastrin (GAS), a key gastrointestinal (GI) hormone, was found to be involved in tumor formation, progression, and metastasis. In this ...

journal_title：International journal of oncology

authors： Zhuang K,Zhang L,Zhang X,Tang H,Zhang J,Yan Y,Han K,Guo H

更新日期：2017-06-01 00:00:00

abstract：:A431 resistant variants to epoxomicin (EXM) were established, showing 4.0-6.7 times more resistance to EXM than parental A431P. Both variants demonstrated increased expression of the beta-subunit molecules of 26S proteasome with approximately 2.5 times increased activity. In variant cells, cyclin B and P34cdc2 were ov...

journal_title：International journal of oncology

authors： Ohkawa K,Asakura T,Aoki K,Shibata S,Minami J,Fujiwara C,Sai T,Marushima H,Kuzuu H

更新日期：2004-02-01 00:00:00

abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

journal_title：International journal of oncology

authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

更新日期：2007-10-01 00:00:00

abstract：:Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and is highly resistant to conventional cancer therapy. A better understanding of the regulatory mechanisms which control the growth of this deadly malignancy are urgently needed to develop more effective cancer intervention strategies. Recent studies h...

journal_title：International journal of oncology

authors： Schuller HM,Plummer HK 3rd,Bochsler PN,Dudric P,Bell JL,Harris RE

更新日期：2001-09-01 00:00:00

abstract：:The cell-adhesion properties of cancer cells can be targeted to block cancer metastasis. Although cytosolic lysyl-tRNA synthetase (KRS) functions in protein synthesis, KRS on the plasma membrane is involved in cancer metastasis. We hypothesized that KRS is involved in cell adhesion-related signal transduction for cell...

journal_title：International journal of oncology

authors： Nam SH,Kang M,Ryu J,Kim HJ,Kim D,Kim DG,Kwon NH,Kim S,Lee JW

更新日期：2016-04-01 00:00:00

abstract：:By setting the cut-off line at the level as used in a negative control study without primary antibody in the same sample, the Ki-67 labeling rate was calculated by the Ki67-DNA dual fluorescence analysis. The mean Ki-67 labeling rate of 28 advanced gastric cancer was 45.1% (13.9-76.3%). The Ki-67 labeling rates were s...

journal_title：International journal of oncology

authors： Kimura H,Yonemura Y,Miyazaki I

更新日期：1992-08-01 00:00:00

abstract：:We established new two protein-free culture subclones from murine well-characterized Ehrlich ascites carcinoma and P815 mastocytoma using intermittent protein-free culture performed previously for a protein-free subclone of fibrosarcoma (Gc-4 PF). The Ehrlich protein-free subclone (Ehrlich PF) grew much more slowly th...

journal_title：International journal of oncology

authors： Watanabe H,Chigira M

更新日期：1992-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a major cause of cancer deaths. Concurrent administration of radiation and chemotherapy is the treatment of choice for advanced NPC. Previously, we showed that apogossypolone (ApoG2) induced apoptosis by blocking the binding of Bcl-2 to Bax, arresting the cell cycle in the S phase, in...

journal_title：International journal of oncology

authors： He JH,Liao XL,Wang W,Li DD,Chen WD,Deng R,Yang D,Han ZP,Jiang JW,Zhu XF

更新日期：2014-09-01 00:00:00

abstract：:Gene therapy is a newly hatched field of biomedical research aimed at introducing therapeutically important genes into somatic cells of patients for the treatment of human disease. Whereas for inborn errors of metabolism transfer of a single gene can correct the disorder, cancer is a complex disease involving mutation...

journal_title：International journal of oncology

authors： Boulikas T

更新日期：1996-11-01 00:00:00

abstract：:Metallothionein 3 (MT-3) has the ability to regulate the growth of nerve cells, but the significance of MT-3 expression outside the central nervous system and its participation in carcinogenesis have not yet been clarified. The aim of our study was to investigate the expression of MT-3 in ductal breast cancer and to d...

journal_title：International journal of oncology

authors： Gomulkiewicz A,Jablonska K,Pula B,Grzegrzolka J,Borska S,Podhorska-Okolow M,Wojnar A,Rys J,Ambicka A,Ugorski M,Zabel M,Dziegiel P

更新日期：2016-12-01 00:00:00

abstract：:According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...

journal_title：International journal of oncology

authors： Furihata M,Sonobe H,Ohtsuki Y

更新日期：1995-06-01 00:00:00

abstract：:Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the contribution of endogenous CCK to tumor growth is unknown. The purpose of this study was to evaluate the role of endogenous CCK on autocrine growth of pancreatic cancer...

journal_title：International journal of oncology

authors： Matters GL,McGovern C,Harms JF,Markovic K,Anson K,Jayakumar C,Martenis M,Awad C,Smith JP

更新日期：2011-03-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00