Abstract:
:Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7 gene without intron and the FZD7 cDNAs isolated from esophageal cancer cell lines TE4 and TE5 were found to encode WNT receptor identical to FZD7, but not to FzE3. Nucleotide sequence of FzE3 was not identified on the human genome draft sequence. Thus, we could not obtain any data suggesting the existence of FzE3. Expression profile of FZD7 was also investigated. FZD7 was expressed throughout normal gastrointestinal tract, from esophagus to rectum. Among human esophageal and gastric cancer cell lines, expression level of FZD7 was relatively lower in esophageal cancer cell lines, and was highest in the gastric cancer cell line MKN7. FZD7 was up-regulated in one out of six cases of human primary gastric cancer. As over-expression of Frizzled-7 leads to activation of the WNT-beta-catenin-TCF pathway, up-regulation of FZD7 in human gastric cancer might play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF pathway.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Kirikoshi H,Sekihara H,Katoh Mkeywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
111-5issue
1eissn
1019-6439issn
1791-2423journal_volume
19pub_type
杂志文章abstract::Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2006-03-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
更新日期:1994-09-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:2016-09-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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更新日期:2015-07-01 00:00:00
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journal_title:International journal of oncology
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pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.5.1125
更新日期:1994-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1014
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3665
更新日期:2016-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.4.771
更新日期:2000-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000407
更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.6.2.391
更新日期:1995-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.3.585
更新日期:2001-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
abstract::The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes. Pituitary adenomas are a group of tumors arising from the pituitary gland: they may be subdivided in...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2017.4120
更新日期:2017-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3542
更新日期:2016-08-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1640
更新日期:2012-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1531
更新日期:2012-09-01 00:00:00