Abstract:
:Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dysregulated mRNAs, and these were enriched in GO and KEGG pathways associated with cancer progression and chemoresistance development. Among these lncRNA-mRNA interactions, some lncRNAs may cis‑regulate neighboring protein-coding genes and be involved in chemoresistance. We then validated that the lncRNA NONHSAT028712 regulated nearby CDK2 and interfered with the cell cycle and chemoresistance. Furthermore, we identified another group of lncRNAs that trans-regulated genes by interacting with different transcription factors. For example, NONHSAT057282 and NONHSAG023333 modulated chemoresistance and most likely interacted with the transcription factors ELF1 and E2F1, respectively. In conclusion, in the present study, we report for the first time the lncRNA expression patterns in adriamycin-resistant breast cancer cells, and provide a group of novel lncRNA targets that mediate chemoresistance development in both cis- and trans-action modes.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
He DX,Zhang GY,Gu XT,Mao AQ,Lu CX,Jin J,Liu DQ,Ma Xdoi
10.3892/ijo.2016.3665subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1695-1703issue
4eissn
1019-6439issn
1791-2423journal_volume
49pub_type
杂志文章abstract::One of the genes that the authors have isolated by a differential display of hepatocellular carcinoma compared to adjacent liver is the alpha6 integrin. alpha6 integrin is the major adhesion receptor for laminin and is suggested to be involved in tumor cell invasion and metastasis. To our knowledge, however, there are...
journal_title:International journal of oncology
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abstract::The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...
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journal_title:International journal of oncology
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doi:10.3892/ijo.2017.3978
更新日期:2017-06-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:10.3892/ijo.14.4.721
更新日期:1999-04-01 00:00:00
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journal_title:International journal of oncology
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doi:
更新日期:2004-05-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
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