miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC.

abstract：:We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and...

journal_title：International journal of oncology

authors： Maruiwa M,Yano H,Fukuda K,Ogasawara S,Hisaka T,Yamaguchi R,Kojiro M

更新日期：1996-06-01 00:00:00

abstract：:A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...

journal_title：International journal of oncology

authors： Ise W,Heuser M,Sanders K,Beck J,Gekeler V

更新日期：1996-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...

journal_title：International journal of oncology

authors： Fan X,Wei J,Xiong H,Liu X,Benichou S,Gao X,Liu L

更新日期：2015-10-01 00:00:00

abstract：:WNT signaling pathway plays a key role in carcinogenesis and embryogenesis. We have cloned and characterized the human WNT5B. Overlapping WNT5B cDNAs, containing 1080-bp ORF, were isolated. WNT5B encoded a 359-amino-acid polypeptide with the N-terminal signal peptide, four N-linked glycosylation sites, and consensus a...

journal_title：International journal of oncology

authors： Saitoh T,Katoh M

更新日期：2001-08-01 00:00:00

abstract：:Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...

journal_title：International journal of oncology

authors： Rieger C,Huebner D,Temme A,Wirth MP,Fuessel S

更新日期：2015-09-01 00:00:00

abstract：:2-Phenyl-4-quinolone series compounds have exhibited growth inhibitory influence on several human cancer cell lines. In this study, we investigated the effects of 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) on viability, cell cycle and apoptotic cell death which occurred in different leukemia c...

journal_title：International journal of oncology

authors： Huang SM,Yang JS,Tsai SC,Chen MH,Hsu MH,Lin HY,Chou LC,Chinag JH,Lee KH,Huang LJ,Kuo SC

更新日期：2011-05-01 00:00:00

abstract：:The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody ...

journal_title：International journal of oncology

authors： Ishikawa T,Furihata M,Ohtsuki Y,Ono H,Inoue A,Ogoshi S

更新日期：1997-11-01 00:00:00

abstract：:Selenium is a trace nutrient element that protects cells against oxidative damage. In this study, the potential of selenium to improve stem cell potency through active proliferation and migration of 3T3-L1 preadipocytes was investigated, together with the underlying molecular mechanisms. The results indicated that sel...

journal_title：International journal of oncology

authors： Park SH,Kim JH,Nam SW,Kim BW,Kim GY,Kim WJ,Choi YH

更新日期：2014-01-01 00:00:00

abstract：:The interactions between cells and the extracellular matrix (EM) have important effects on tumor invasion and metastasis. Osteosarcoma (OS) is a highly metastatic tumor, secondary lesions occurring early in the natural history of the disease. Despite the clinical relevance of disseminated disease in this neoplasia, th...

journal_title：International journal of oncology

authors： Scotlandi K,Serra M,Manara M,Nanni P,Nicoletti G,Landuzzi L,Maurici D,Baldini N

更新日期：1993-11-01 00:00:00

abstract：:Telomerase activation in differentiated cells is associated with cell immortalization. Detection of telomerase expression in cancer provides a potential biomarker to be evaluated in the diagnosis and prognosis of cancer patients. Analysis of telomerase activity in biopsy specimens may serve as a useful marker for the ...

journal_title：International journal of oncology

authors： Pearson AS,Chiao P,Zhang L,Zhang W,Larry L,Katz RL,Evans DB,Abbruzzese JL

更新日期：2000-08-01 00:00:00

abstract：:The retinoic acid receptor (RAR) beta gene is located in a region on chromosome 3p, which is frequently deleted in renal cell carcinoma. Since retinoic acid (RA) can inhibit cell proliferation and tumor formation, loss of RAR beta might contribute to oncogenesis of the kidney. This prompted us to examine RAR beta expr...

journal_title：International journal of oncology

authors： Vanderleede B,Opdenoordt T,Vandenbrink C,Ebert T,Vandersaag P

更新日期：1995-02-01 00:00:00

abstract：:Mesothelioma is an aggressive tumor which is mainly derived from the pleura of lung. In the present study, we evaluated the anticancer effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor on human mesothelioma cells in relation to the levels of HDAC1, reactive oxygen species (ROS) a...

journal_title：International journal of oncology

authors： You BR,Park WH

更新日期：2016-05-01 00:00:00

abstract：:The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing. The reasons for the failure of the mechanisms of resistance of these inhibitors are unclear, but may involve factors of the tumor microenvironment ...

journal_title：International journal of oncology

authors： Hartel I,Ronellenfitsch M,Wanka C,Wolking S,Steinbach JP,Rieger J

更新日期：2016-07-01 00:00:00

abstract：:Family with sequence similarity 83 member A (FAM83A) has been recently observed to be upregulated in various types of cancer and hypothesized to be serve as an oncogene. The present study aimed to determine the functional roles and the underlying molecular mechanism of FAM83A in cervical cancer. The results demonstrat...

journal_title：International journal of oncology

authors： Xu J,Lu W

更新日期：2020-08-01 00:00:00

abstract：:Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...

journal_title：International journal of oncology

authors： Ratajczak-Wielgomas K,Grzegrzolka J,Piotrowska A,Matkowski R,Wojnar A,Rys J,Ugorski M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:In a retrospective analysis of 91 consecutive oral carcinomas we reviewed all patient records and weighed clinicopathological parameters against the results of image DNA cytometry and p53 immunhistochemical staining of the initial diagnostic biopsies. Eighty-seven percent of the biopsies were either aneuploid or nondi...

journal_title：International journal of oncology

authors： Hogmo A,Munckwikland E,Kuylenstierna R,Lindholm J,Auer G

更新日期：1994-10-01 00:00:00

abstract：:Curcumin (diferulolylmethane), an active ingredient derived from the rhizome of the plant Curcuma longa, has anticancer activity in vitro and in vivo. Although curcumin possesses chemopreventive properties against several types of cancer, the molecular mechanisms by which it inhibits cell growth and induces apoptosis ...

journal_title：International journal of oncology

authors： Shankar S,Srivastava RK

更新日期：2007-04-01 00:00:00

abstract：:Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune res...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：2015-12-01 00:00:00

abstract：:Macrophages are a major component of the leukocyte infiltrate of tumors and play a pivotal role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which macrophages promote HCC invasion are poorly understood. The present study was undertaken to investigate the relationship betwe...

journal_title：International journal of oncology

authors： Fu XT,Dai Z,Song K,Zhang ZJ,Zhou ZJ,Zhou SL,Zhao YM,Xiao YS,Sun QM,Ding ZB,Fan J

更新日期：2015-02-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family and is highly expressed in several types of cancer cells and/or stromal tissue. Lumican expression in the cytoplasm in advanced colorectal cancer correlates with poor patient prognosis. The expression of lumican in stromal tissues is associated with a hig...

journal_title：International journal of oncology

authors： Matsuda Y,Yamamoto T,Kudo M,Kawahara K,Kawamoto M,Nakajima Y,Koizumi K,Nakazawa N,Ishiwata T,Naito Z

更新日期：2008-12-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...

journal_title：International journal of oncology

authors： Wang H,Dai YY,Zhang WQ,Hsu PC,Yang YL,Wang YC,Chan G,Au A,Xu ZD,Jiang SJ,Wang W,Jablons DM,You L

更新日期：2017-07-01 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, able to prevent the CDK2/cyclin E induced retinoblastoma protein (pRB) phosphorylation, thus inhibiting cell cycle progression at G1 phase. p21WAF1/CIP1 protein levels were examined in a series of 102 ovarian tissue samples including normal ovary, primary ov...

journal_title：International journal of oncology

authors： Ferrandina G,Stoler A,Fagotti A,Fanfani F,Sacco R,De Pasqua A,Mancuso S,Scambia G

更新日期：2000-12-01 00:00:00

abstract：:The development of resistance to anticancer agents during treatment is a major obstacle in the chemotherapy of cancer. Cells expressing high levels of the P-glycoprotein exhibit a multidrug resistance phenotype. The P-glycoprotein is a membrane phosphoprotein which serves as a drug efflux pump to reduce intracellular ...

journal_title：International journal of oncology

authors： Srivastava R,Srivastava A,Chochung Y

更新日期：1996-11-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is cytotoxic to the majority of cancer cells while sparing most normal cells. However, different prostate carcinoma cell lines respond with different sensitivities to TRAIL, urging us to disclose the mechanisms that determine TRAIL sensitivity in prostate...

journal_title：International journal of oncology

authors： Sonnemann J,Gekeler V,Sagrauske A,Müller C,Hofmann HP,Beck JF

更新日期：2004-10-01 00:00:00

abstract：:Selectivity of the anticancer agent PB-100 for malignant cells, already demonstrated using cell growth and viability evaluation, is now confirmed by microscopic observations. PB-100 is easily detected inside cells by its yellow color under visible light and by its blue fluorescence; it may be measured in isolated nucl...

journal_title：International journal of oncology

authors： Beljanski M,Crochet S

更新日期：1995-07-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00