p21WAF1/CIP1 protein expression in primary ovarian cancer.

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...

journal_title：International journal of oncology

authors： Ahmad SS,Glatzle J,Bajaeifer K,Bühler S,Lehmann T,Königsrainer I,Vollmer JP,Sipos B,Ahmad SS,Northoff H,Königsrainer A,Zieker D

更新日期：2013-08-01 00:00:00

abstract：:Cancer antigens RAK-p120, p42, and p25, which exhibit biological, immunological and molecular similarity to the proteins expressed by Human Immunodeficiency Virus 1 (HIV-1), were found in 47 of 47 tested cases of serous adenocarcinoma of the ovary, and 45 of 45 tested cases of squamous carcinoma of the cervix. Normal ...

journal_title：International journal of oncology

authors： Rakowiczszulczynska E,Roszak A,Mackiewicz A,Markowska J,McIntosh D,Karczewska A,Godlewski D,Snyder W,Leary D,Smith M

更新日期：1996-10-01 00:00:00

abstract：:Lisofylline, a dimethylxanthine derivative, has been shown to block the induction of hematopoietic growth inhibitors produced in response to cytotoxic anticancer therapy. In the current study, mice bearing established EMT-6 mammary carcinoma were treated with high dose cyclophosphamide, melphalan, BCNU, 5-fluorouracil...

journal_title：International journal of oncology

authors： Teicher B,Kakeji Y,Northey D

更新日期：1997-08-01 00:00:00

abstract：:Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...

journal_title：International journal of oncology

authors： Yang JY,Xia W,Hu MC

更新日期：2006-09-01 00:00:00

abstract：:Induction of differentiation represents a promising concept for chemotherapy of malignant gliomas, which are often refractory even to the combined treatment with surgery, irradiation and chemotherapy. Since anti-neoplastic alkylphosphocholines can induce differentiation of leukemic cell lines, the effects of the intra...

journal_title：International journal of oncology

authors： Jendrossek V,Kugler W,Erdlenbruch B,Eibl H,Lakomek M

更新日期：2001-10-01 00:00:00

abstract：:The monocyte chemotactic protein 3 (MCP-3) belongs to the MCP subgroup of the CC chemokines and promotes chemotaxis of immune cells. MCP-1 is believed to play an important role in monocyte infiltration into tumor tissues; however, the relationship between tumor-infiltrating macrophage/microglia (TIM/M) and the express...

journal_title：International journal of oncology

authors： Okada M,Saio M,Kito Y,Ohe N,Yano H,Yoshimura S,Iwama T,Takami T

更新日期：2009-06-01 00:00:00

abstract：:Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...

journal_title：International journal of oncology

authors： Wada H,Yamamoto H,Kim C,Uemura M,Akita H,Tomimaru Y,Hama N,Kawamoto K,Kobayashi S,Eguchi H,Umeshita K,Doki Y,Mori M,Nagano H

更新日期：2014-09-01 00:00:00

abstract：:Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different levels of regulation,...

journal_title：International journal of oncology

authors： Gómez DL,Farina HG,Gómez DE

更新日期：2013-11-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) factor plays an important role in the tumorigenicity of cancer stem cells. The purpose of this study was to investigate the inhibitory mechanism of this pathway acting through the tumor suppressor von Hippel-Lindau (VHL) protein in glioma cancer stem cells...

journal_title：International journal of oncology

authors： Kanno H,Sato H,Yokoyama TA,Yoshizumi T,Yamada S

更新日期：2013-03-01 00:00:00

abstract：:After the publication of the article, the authors have realized that the affiliation presented for the joint co‑author listed on the paper (Jian‑Ren Tu) was incorrect. The correct author list (and affiliations) should therefore have been published as follows: Yu‑Hua Xu1*, Jian‑Ren Tu2*, Tian‑Tian Zhao3, Shi‑Guang Xie3...

journal_title：International journal of oncology

authors： Xu YH,Tu JR,Zhao TT,Xie SG,Tang SB

更新日期：2019-07-01 00:00:00

abstract：:Signet ring cell gastric cancer (SRCGC) has very poor prognosis worldwide, and studying its molecular characteristics is urgent for improving the outcome. However, few well-characterized SRCGC cell lines are available for research. Therefore, we established a novel cell line GCSR1, from a Chinese male SRCGC patient. C...

journal_title：International journal of oncology

authors： Xu X,Qian LJ,Su XY,He KF,Jin KT,Gu LH,Feng JG,Li GL,Zhou Q,Xu ZZ,Wang HH,Zhang J,Cao J,Teng LS

更新日期：2015-01-01 00:00:00

abstract：:On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRR...

journal_title：International journal of oncology

authors： Fujitomo T,Daigo Y,Matsuda K,Ueda K,Nakamura Y

更新日期：2014-07-01 00:00:00

abstract：:Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against brea...

journal_title：International journal of oncology

authors： Echiburú-Chau C,Alfaro-Lira S,Brown N,Salas CO,Cuellar M,Santander J,Ogalde JP,Rothhammer F

更新日期：2014-04-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:The p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation. There are several reports that the reintroduction of the p16INK4A gene into p16(-) NSCLC cells results i...

journal_title：International journal of oncology

authors： Sumitomo K,Shimizu E,Shinohara A,Yokota J,Sone S

更新日期：1999-06-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) seems to have a pivotal role in maintaining the normal phenotype by suppressing cell growth through blocking the entrance of quiescent cells into the cell cycle. MnSOD protein expression has been shown to be dysregulated in malignant cells. A well-established experimental breast ...

journal_title：International journal of oncology

authors： Echiburú-Chau C,Roy D,Calaf GM

更新日期：2011-06-01 00:00:00

abstract：:CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...

journal_title：International journal of oncology

authors： Jing F,Kim HJ,Kim CH,Kim YJ,Lee JH,Kim HR

更新日期：2015-04-01 00:00:00

abstract：:Although histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy in malignancy, how they exert their effect on human non-small cell lung cancer cells is as yet unclear. This study was undertaken to investigate the underlying mechanism of an HDAC inhibitor, Trichostatin A (TSA), -induce...

journal_title：International journal of oncology

authors： Choi YH

更新日期：2005-08-01 00:00:00

abstract：:Peripheral blood was examined for the presence of tumor cells at multiple time points over a one-year period in 45 patients with a history of surgical resection of breast carcinoma. The number of circulating epithelial cells in 8 of 8 patients with clinically active disease concurred or preceded changes in the disease...

journal_title：International journal of oncology

authors： Terstappen LW,Rao C,Gross S,Weiss AJ

更新日期：2000-09-01 00:00:00

abstract：:RLIP76, a stress-responsive, multi-functional protein with multi-specific transport activity towards glutathione-conjugates (GS-E) and chemotherapeutic agents is frequently overexpressed in malignant cells. Our recent studies suggest that it plays a prominent anti-apoptotic role selectively in cancer cells. The presen...

journal_title：International journal of oncology

authors： Singhal SS,Sehrawat A,Mehta A,Sahu M,Awasthi S

更新日期：2009-01-01 00:00:00

abstract：:CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baical...

journal_title：International journal of oncology

authors： Ohkoshi E,Umemura N

更新日期：2017-02-01 00:00:00

abstract：:Gene amplification is frequently found in human glioblastoma but the mechanisms driving amplifications remain to be elucidated. Hypoxia as hallmark of glioblastoma is known to be involved in the induction of fragile sites that are central to gene amplification. We analyzed the potential of hypoxia (pO2 0%) and mini hy...

journal_title：International journal of oncology

authors： Fischer U,Radermacher J,Mayer J,Mehraein Y,Meese E

更新日期：2008-09-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:This study evaluated the effects of a combination of opioid growth factor (OGF) and paclitaxel on squamous cell carcinoma of the head and neck (SCCHN) using a tissue culture model of human SCCHN. The combination of OGF and paclitaxel was markedly inhibitory to SCCHN proliferation, reducing growth from control levels b...

journal_title：International journal of oncology

authors： McLaughlin PJ,Jaglowski JR,Verderame MF,Stack BC,Leure-Dupree AE,Zagon IS

更新日期：2005-03-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...

journal_title：International journal of oncology

authors： He DX,Zhang GY,Gu XT,Mao AQ,Lu CX,Jin J,Liu DQ,Ma X

更新日期：2016-10-01 00:00:00

abstract：:Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The re...

journal_title：International journal of oncology

authors： Zhang Y,Ying X,Han S,Wang J,Zhou X,Bai E,Zhang J,Zhu Q

更新日期：2013-01-01 00:00:00

abstract：:Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...

journal_title：International journal of oncology

authors： Sartippour MR,Heber D,Zhang L,Beatty P,Elashoff D,Elashoff R,Go VL,Brooks MN

更新日期：2002-09-01 00:00:00

abstract：:Surfactant proteins play important roles in lung surfactant function and innate immunity. The DNA methylation state of 11 CpG sites of surfactant protein (SP)-A1, -B, -C, and -D was determined using universal bead arrays. A total of 90 cancerous and non-cancerous tissues from 23 patients with adenocarcinoma and 22 wit...

journal_title：International journal of oncology

authors： Lin Z,Thomas NJ,Bibikova M,Seifart C,Wang Y,Guo X,Wang G,Vollmer E,Goldmann T,Garcia EW,Zhou L,Fan JB,Floros J

更新日期：2007-07-01 00:00:00

abstract：:Conventional diagnosis of prostate cancer does not appear to be sensitive enough to differentiate pre-operatively between organ-confined and extracapsular disease. New technologies, arising from the field of molecular biology, have been introduced to improve diagnosis and their implementation into the clinical practic...

journal_title：International journal of oncology

authors： Schamhart DH,Maiazza R,Kurth KH

更新日期：2005-03-01 00:00:00