Abstract:
:Induction of differentiation represents a promising concept for chemotherapy of malignant gliomas, which are often refractory even to the combined treatment with surgery, irradiation and chemotherapy. Since anti-neoplastic alkylphosphocholines can induce differentiation of leukemic cell lines, the effects of the intravenously applicable alkylphosphocholine-derivative erucylphosphocholine (ErPC) on proliferation, morphology and differentiation of the rat glioma cell line C6 was examined in vitro. Short-term exposure to ErPC induced accumulation of the cells in the G2/M-phase of the cell cycle and apoptotic cell death. In contrast, continuous exposure of C6 rat glioma cells to sublethal ErPC doses (30 and 50 microM) caused both the formation of a slower growing tetraploid cell population and astrocytic differentiation. No resistance to in vivo obtainable ErPC concentrations was observed during this treatment. We conclude that ErPC-induced differentiation might be beneficial for a long-term adjuvant chemotherapy of low grade glioma.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Jendrossek V,Kugler W,Erdlenbruch B,Eibl H,Lakomek Mdoi
10.3892/ijo.19.4.673keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
673-80issue
4eissn
1019-6439issn
1791-2423journal_volume
19pub_type
杂志文章abstract::Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2651
更新日期:2014-12-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:2020-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.10.6.1235
更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.2012.1676
更新日期:2013-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:International journal of oncology
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