Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port.

abstract：:With a view to identifying markers reflecting not the evidence of, but the potential for, neoplastic progression of the breast we have compared the normal invasive mammary epithelial cell growth seen at puberty with invasive and non-invasive carcinogenesis using the mouse as a model. We have analyzed cell proliferatio...

journal_title：International journal of oncology

authors： Djonov V,Altermatt H,Arnold A,Gerber H,Andres A

更新日期：1995-08-01 00:00:00

abstract：:Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases re...

journal_title：International journal of oncology

authors： Dong Z,Yang J,Li L,Tan L,Shi P,Zhang J,Zhong X,Ge L,Wu Z,Cui H

更新日期：2020-03-01 00:00:00

abstract：:We established new two protein-free culture subclones from murine well-characterized Ehrlich ascites carcinoma and P815 mastocytoma using intermittent protein-free culture performed previously for a protein-free subclone of fibrosarcoma (Gc-4 PF). The Ehrlich protein-free subclone (Ehrlich PF) grew much more slowly th...

journal_title：International journal of oncology

authors： Watanabe H,Chigira M

更新日期：1992-09-01 00:00:00

abstract：:The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection...

journal_title：International journal of oncology

authors： Ido E,Furihata M,Ohtsuki Y,Iwata J,Sonobe H

更新日期：1994-08-01 00:00:00

abstract：:Secreted frizzled related proteins (SFRPs) are a family of Wnt regulators which are frequently downregulated in cancers. In malignant mesothelioma (MM), downregulation of SFRP4 has been reported as a mechanism which contributes to aberrant activation of oncogenic Wnt signaling. Here we investigated the biological cons...

journal_title：International journal of oncology

authors： Perumal V,Dharmarajan AM,Fox SA

更新日期：2017-07-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00

abstract：:In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to...

journal_title：International journal of oncology

authors： Gupta S

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at ...

journal_title：International journal of oncology

authors： Denzinger S,Stoehr R,Schwarz S,Eichenseher N,Brockhoff G,Obermann EC,Knuechel R,Blaszyk H,Hartmann A,Wild PJ

更新日期：2007-10-01 00:00:00

abstract：:A total of forty-one tumor infiltrating T cell lines (TIL) were cloned, in the presence of interleukin-2, from nine breast tumor and five melanoma specimens with limiting dilution in a microculture system. Nineteen (46%) of the lines/clones reacted to autologous tumor targets. The T cell receptor (TcR) V beta gene usa...

journal_title：International journal of oncology

authors： Chin Y,Janssens J,Bleus J,Vandevijver C,Zhang J,Raus J

更新日期：1995-07-01 00:00:00

abstract：:Choriocarcinoma is a highly malignant trophoblastic tumor related to pregnancy that often occurs with a complete hydatidiform mole. It grows quickly and can also widely metastasize to other organs or tissues through both the venous and lymphatic systems. The transforming growth factor-β1 (TGF-β1) belongs to a growth f...

journal_title：International journal of oncology

authors： Xu Q,Tan Y,Zhang K,Li Y

更新日期：2013-10-01 00:00:00

abstract：:Despite attempts to use multiple drug combinations that include gemcitabine (GEM), there is very little evidence that these combination regimens are superior to the single use of this agent. We therefore investigated the suppressive effect of the combination of systemically administered GEM and locally administered in...

journal_title：International journal of oncology

authors： Ito Y,Aiura K,Ueda M,Kitajima M,Kitagawa Y

更新日期：2008-07-01 00:00:00

abstract：:Pancreatic cancer is characterized by a dense desmoplastic reaction in which extracellular matrix proteins accumulate and surround tumor cells. Integrins and their related signaling molecules are associated with progression of pancreatic cancer. In the present study, the association between the metastasis of pancreati...

journal_title：International journal of oncology

authors： Jiang P,Li Z,Tian F,Li X,Yang J

更新日期：2017-07-01 00:00:00

abstract：:HER-2/neu status and t-PA, u-PA, and PAI-1 cytosol content were evaluated in 88 primary breast cancer patients to determine the relationships between these parameters. HER-2/neu was amplified in 24% (20/84) of tumor samples and overexpressed in 28% (14/50). In the overall series, median t-PA, u-PA and PAI-1 contents, ...

journal_title：International journal of oncology

authors： Tommasi S,Rella C,Giannella C,Quaranta M,Schittulli F,Paradiso A,Coviello M,Delena M

更新日期：1994-09-01 00:00:00

abstract：:We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which cont...

journal_title：International journal of oncology

authors： Gutierrez M,Bhatia K,Diez B,Muriel F,Epelman S,Deandreas M,Huppi K,Magrath I

更新日期：1994-03-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are potentially mutagenic/carcinogenic lesions. Induction of DSBs triggers phosphorylation of histone H2AX on Ser-139. Phosphorylated H2AX (gammaH2AX) can be detected immunocytochemically, and the intensity of gammaH2AX immunofluorescence (IF), reflecting the number of gammaH2AX-IF foci...

journal_title：International journal of oncology

authors： Albino AP,Huang X,Jorgensen ED,Gietl D,Traganos F,Darzynkiewicz Z

更新日期：2006-06-01 00:00:00

abstract：:Frizzled (FZD) genes encode receptors for WNTs, which play key roles in carcinogenesis and embryogenesis. We have previously cloned the FZD10 gene, and demonstrated up-regulation of FZD10 mRNA in the cervical cancer cell line HeLa S3, gastric cancer cell lines TMK1 and MKN74, and 4 cases out of 10 cases of primary gas...

journal_title：International journal of oncology

authors： Saitoh T,Mine T,Katoh M

更新日期：2002-01-01 00:00:00

abstract：:One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine proteases prevent DNA degradation and abrogate other signs of apoptosis in several cell systems (Gorczyca et al, Int J Oncol 1: ...

journal_title：International journal of oncology

authors： Gorczyca W,Ardelt B,Darzynkiewicz Z

更新日期：1993-10-01 00:00:00

abstract：:Recombinant adenovirus-associated vector serotype 2 (rAAV2) is one of the most promising gene transfer vectors due to its advantage of causing non-pathogenic infection, low immunogenicity, and long-term gene expression in human clinical trials. Human interleukin 15 (hIL15) has been implicated in modulation of antitumo...

journal_title：International journal of oncology

authors： Yu YL,Wei CW,Chen YL,Chen MH,Yiang GT

更新日期：2010-02-01 00:00:00

abstract：:A slowly proliferating cell fraction in tumors shows reduced sensitivity to cell cycle-dependent anticancer agents. To understand the molecular basis of drug resistance observed in brain tumors, we examined the relationship between alteration of p16, a cyclin dependent kinase inhibitor whose functions are frequently l...

journal_title：International journal of oncology

authors： Iwadate Y,Mochizuki S,Fujimoto S,Namba H,Sakiyama S,Tagawa M,Yamaura A

更新日期：2000-09-01 00:00:00

abstract：:Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...

journal_title：International journal of oncology

authors： Jatoi A,Foster NR,Egner JR,Burch PA,Stella PJ,Rubin J,Dakhil SR,Sargent DJ,Murphy BR,Alberts SR

更新日期：2010-03-01 00:00:00

abstract：:The effects of pretreatment with the multidrug resistance (MDR) modulators verapamil (VPM), tamoxifen (TMX), cyclosporin A (CsA), and SDZ PSC833 (PSC) on drug sensitivity of the P-glycoprotein (Pgp) expressing human ileocecal carcinoma cell line HCT-8 is described. Following pretreatment of 2, 16 and 48 h with the ind...

journal_title：International journal of oncology

authors： Haberl I,Swatonek H,Schaufler K,Ulsperger E,Wenzl E,Theyer G,Hamilton G,Thalhammer T

更新日期：1998-05-01 00:00:00

abstract：:The p53-induced wig-1 gene encodes an unusual nuclear zinc finger protein with high sequence similarity between human, rat and mouse. Wig-1 belongs to a group of proteins with widely spaced zinc fingers that bind double stranded (ds) RNA. We show here that wig-1 is present in Gallus gallus (chicken), Silurana tropical...

journal_title：International journal of oncology

authors： Hellborg F,Wiman KG

更新日期：2004-06-01 00:00:00

abstract：:Sialic acid-containing glycosphingolipids, gangliosides, are expressed at high levels in the nerve tissues and various tumor cells. Although a number of studies on the roles of gangliosides in the regulation of cell proliferation have been performed, the mechanisms for the regulation are not well understood. We establ...

journal_title：International journal of oncology

authors： Nishio M,Tajima O,Furukawa K,Urano T,Furukawa K

更新日期：2005-01-01 00:00:00

abstract：:Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prost...

journal_title：International journal of oncology

authors： Li H,Gu Y,Miki J,Hukku B,McLeod DG,Hei TK,Rhim JS

更新日期：2007-09-01 00:00:00

abstract：:Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...

journal_title：International journal of oncology

authors： Konduri S,Lakka SS,Tasiou A,Yanamandra N,Gondi CS,Dinh DH,Olivero WC,Gujrati M,Rao JS

更新日期：2001-09-01 00:00:00

abstract：:Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulation of hTERT. All-trans retinoic acid (ATRA) induces differentiation in...

journal_title：International journal of oncology

authors： Love WK,Berletch JB,Andrews LG,Tollefsbol TO

更新日期：2008-03-01 00:00:00

abstract：:Orlistat is an orally administered anti-obesity drug that has shown significant antitumor activity in a variety of tumor cells. To identify the proteins involved in its antitumor activity, we employed a proteomic approach to reveal protein expression changes in the human ovarian can...

journal_title：International journal of oncology

authors： Huang HQ,Tang J,Zhou ST,Yi T,Peng HL,Shen GB,Xie N,Huang K,Yang T,Wu JH,Huang CH,Wei YQ,Zhao X

更新日期：2012-08-01 00:00:00

abstract：:The p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation. There are several reports that the reintroduction of the p16INK4A gene into p16(-) NSCLC cells results i...

journal_title：International journal of oncology

authors： Sumitomo K,Shimizu E,Shinohara A,Yokota J,Sone S

更新日期：1999-06-01 00:00:00

abstract：:Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...

journal_title：International journal of oncology

authors： Nowak A,Grzegrzółka J,Kmiecik A,Piotrowska A,Matkowski R,Dzięgiel P

更新日期：2018-02-01 00:00:00

abstract：:Angiogenesis plays a critical role in the development of solid tumors by supplying nutrients and oxygen to support continuous growth of tumor as well as providing an avenue for hematogenous metastasis. Tumor angiogenesis is highly regulated by multiple intracellular signaling transduction cascades such as Hedgehog, ST...

journal_title：International journal of oncology

authors： Lin J,Chen Y,Wei L,Hong Z,Sferra TJ,Peng J

更新日期：2013-11-01 00:00:00