Abstract:
:Recombinant adenovirus-associated vector serotype 2 (rAAV2) is one of the most promising gene transfer vectors due to its advantage of causing non-pathogenic infection, low immunogenicity, and long-term gene expression in human clinical trials. Human interleukin 15 (hIL15) has been implicated in modulation of antitumor activity of lymphokine-activated killer (LAK) cells, including T cells and NK cells. In this study, the rAAV2-hIL15 vector was produced and subjected for treatment with xenograft JC breast cancer model. Results showed that tumor onset was significantly delayed, the tumor growth was suppressed, and the lifespan of tumor-bearing mice were prolonged by rAAV2-hIL15. In addition, rAAV2-hIL15 was able to produce a substantial expression of IL15 protein that ultimately activated the cytotoxic activity of LAK cells. Furthermore, prominent apoptosis was observed in tumor lesions following injection of rAAV2-hIL15. Taken together, our results suggested that rAAV2-hIL15 appears as a new potential therapeutic tool for breast cancer immunotherapy.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Yu YL,Wei CW,Chen YL,Chen MH,Yiang GTsubject
Has Abstractpub_date
2010-02-01 00:00:00pages
365-70issue
2eissn
1019-6439issn
1791-2423journal_volume
36pub_type
杂志文章abstract::Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy-based gastric carcinoma (GC) treatments, hence, biologically based therapies are urgently needed. Gastrin (GAS), a key gastrointestinal (GI) hormone, was found to be involved in tumor formation, progression, and metastasis. In this ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.3983
更新日期:2017-06-01 00:00:00
abstract::Oxygen tension measurements were made in three tumors: (i) the murine FSaII fibrosarcoma, (ii) the rat 9L gliosarcoma and (iii) the rat 13672 mammary adenocarcinoma using a pO2 histograph. Tumor oxygenation measurements were made while the animals breathed air or breathed carbogen (95% oxygen/5% carbon dioxide). Pento...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.1.13
更新日期:1993-01-01 00:00:00
abstract::We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly dif...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.6.1347
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abstract::The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.15.3.491
更新日期:1999-09-01 00:00:00
abstract::5-Fluorouracil (5-FU), a fluoropyrimidine analogue, is one of the most commonly used anticancer drugs for the treatment of gastrointestinal malignancies. Some studies reported that the cytotoxicity of fluoropyrimidines is mediated, in large part, by inhibition of the thymidylate synthase (TS), an essential DNA synthet...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signal...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
abstract::Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000282
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2574
更新日期:2014-10-01 00:00:00
abstract::The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4223
更新日期:2018-02-01 00:00:00
abstract::The Stockholm Central Railway Station in Sweden was investigated for public radiofrequency (RF) radiation exposure. The exposimeter EME Spy 200 was used to collect the RF exposure data across the railway station. The exposimeter covers 20 different radiofrequency bands from 88 to 5,850 MHz. In total 1,669 data points ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3657
更新日期:2016-10-01 00:00:00
abstract::Fatty acid synthase (FASN) is a key enzyme that plays a critical role in numerous metabolic functions by catalyzing the synthesis for long-chain fatty acids. FASN is highly expressed in various human cancers. This preferential expression makes FASN an attractive target for anticance...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1401
更新日期:2012-06-01 00:00:00
abstract::Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.4.759
更新日期:1995-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::Postoperative adjuvant chemotherapy reportedly improves advanced colorectal cancer patients' survival, however, it is necessary to assess what regimens are useful. Doxifluridine (5'-DFUR) is an intermediate of capecitabine approved in Europe and USA to treat metastatic colorectal cancer. 5'-DFUR is metabolized to 5-fl...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-07-01 00:00:00
abstract::Inhibin and activin, members of transforming growth factor beta (TGF beta) superfamily, have been localized immunohistochemically in fetal bovine heart endothelial cells (FBHE), suggesting that these cells produce inhibin/activin proteins. In addition, the mRNAs coding for alpha-, and beta A-subunits of inhibin/activi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.7.4.759
更新日期:1995-10-01 00:00:00
abstract::The epidermal growth factor (EGF) receptor (EGFR) is activated by EGF and other EGF-like growth factors, including amphiregulin (AR). We characterized the localization and mitogenic action of AR in T3M4 and COLO-357 human pancreatic cancer cell lines and determined whether the presence of AR in human pancreatic cancer...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.3.625
更新日期:1995-03-01 00:00:00
abstract::Neuroblastoma (NB) is the most common extra-cranial solid tumor in children and despite aggressive therapy survival rates remain low. One of the contributing factors for low survival rates is aggressive tumor angiogenesis, which is known to increase due to radiation, one of the standard therapies for neuroblastoma. Th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3646
更新日期:2016-10-01 00:00:00
abstract::Dual oxidase 2 (Duox2), one of the seven members of the NADPH oxidase gene family, plays a critical role in generating H2O2 for thyroid hormone biosynthesis and as an integral part of the host defense system of the respiratory epithelium and the gastrointestinal tract. Recent evidence suggests that the regulation of D...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
doi:10.3892/ijo.2019.4871
更新日期:2019-11-01 00:00:00
abstract::The objective of this study was to assess the toxicity and immunological response induced by autologous dendritic cells (DCs) pulsed with allogeneic tumor lysate in a pancreatic cancer patient. The lack of available tumor peptides in pancreatic cancer strongly supports the idea to use allogeneic tumor cells as a sourc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::The intensity of post-treatment melanoma patient follow-up varies widely among physicians. We investigated whether physician age accounts for the observed variation in surveillance intensity among plastic surgeons. A custom-designed questionnaire was mailed to USA and non-USA surgeons, all of whom were members of the ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.1.175
更新日期:2001-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3481
更新日期:2016-06-01 00:00:00
abstract::Because of the constant inflow of information and educational efforts by many organizations, public attention is increasingly focused in finding information about strategies for prevention of cancer. Because of the research efforts of the last twenty years it is now increasingly appreciated that changes in dietary hab...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.6.1387
更新日期:1997-12-01 00:00:00
abstract::The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia-induced growth arrest and apoptosis. The aim of this study was to analyze the overall effect of HIF-1 on tumor growth in a mouse model, em...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-08-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.5.971
更新日期:2000-11-01 00:00:00