A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.

abstract：:Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...

journal_title：International journal of oncology

authors： Uchiyama T,Takahashi H,Endo H,Sugiyama M,Sakai E,Hosono K,Nagashima Y,Inayama Y,Wada K,Hippo Y,Nakajima A

更新日期：2011-10-01 00:00:00

abstract：:Acquirement of multi-drug resistance by tumor cells represents a major obstacle in the management of prostate cancer. Such resistance was demonstrated in the androgen-independent DU-145 cells in response to paclitaxel and the mechanisms by which these cell develops resistance was not understood. The objective of this ...

journal_title：International journal of oncology

authors： Flynn V Jr,Ramanitharan A,Moparty K,Davis R,Sikka S,Agrawal KC,Abdel-Mageed AB

更新日期：2003-08-01 00:00:00

abstract：:Human mammary and thyroid tumors as well as peripheral blood cells of the same patients were examined for the amplification of oncogene fins and the expression of its product. Of the 7 mammary tumors analyzed, amplification of fms was observed in 6 (86%) mammary tumor DNAs, while no amplification was seen in 5 thyroid...

journal_title：International journal of oncology

authors： Haga S,Imai S,Morimoto J,Okumoto M,Nishikawa R,Mori N,Kiyozuka Y,Nagano K,Nishino T,Yamamoto H,Sarkar N

更新日期：1994-10-01 00:00:00

abstract：:Telomeres, repeated DNA sequences (T2AG3)n that guard the ends of chromosomes, serve as a checkpoint for cell-cycle progression and regulate cell senescence and apoptosis. Loss of the telomeric repeats promotes genomic instability, which is the hallmark of most cancer cells. Whether this loss differs among tumor cells...

journal_title：International journal of oncology

authors： Multani AS,Ozen M,Sen S,Mandal AK,Price JE,Fan D,Radinsky R,Ali-Osman F,Von Eschenbach AC,Fidler IJ,Pathak S

更新日期：1999-09-01 00:00:00

abstract：:HER-2/neu status and t-PA, u-PA, and PAI-1 cytosol content were evaluated in 88 primary breast cancer patients to determine the relationships between these parameters. HER-2/neu was amplified in 24% (20/84) of tumor samples and overexpressed in 28% (14/50). In the overall series, median t-PA, u-PA and PAI-1 contents, ...

journal_title：International journal of oncology

authors： Tommasi S,Rella C,Giannella C,Quaranta M,Schittulli F,Paradiso A,Coviello M,Delena M

更新日期：1994-09-01 00:00:00

abstract：:Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy and highlighting ...

journal_title：International journal of oncology

authors： Du Y,Shi A,Han B,Li S,Wu D,Jia H,Zheng C,Ren L,Fan Z

更新日期：2014-04-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...

journal_title：International journal of oncology

authors： Tameda M,Sugimoto K,Shiraki K,Yamamoto N,Okamoto R,Usui M,Ito M,Takei Y,Nobori T,Kojima T,Suzuki H,Uchida M,Uchida K

更新日期：2014-08-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have realized that Figs. 3 and 4 contained errors. Two sets of bands in Figs. 3D and 4B were erroneously placed during the process of figure preparation. In Fig. 3D, the β‑actin bands for the PANC‑1 and CFPAC‑1 cells were presented incorrectly, whereas in...

journal_title：International journal of oncology

authors： Ning Z,Wang A,Liang J,Xie Y,Liu J,Feng L,Yan Q,Wang Z

更新日期：2019-11-01 00:00:00

abstract：:One hundred and eighty-one breast cancer specimens were analyzed for nuclear p53 staining by immunochemical methods. There were 123 fine-needle cytological specimens and 58 frozen tissue sections of surgical biopsies. The microscopic evaluation of the staining fitted with a 4 group classification. Ninety-one samples (...

journal_title：International journal of oncology

authors： Lesec G,Richardcoulet E,Collet J,Demaublanc M,Merle S,Salmon R,Remvikos Y

更新日期：1997-04-01 00:00:00

abstract：:Many traditional healing plants successfully passed several hundred years of empirical testing against specific diseases and thereby demonstrating that they are well tolerated in humans. Although quite a few ethno-pharmacological plants are applied against a variety of conditions there are still numerous plants that h...

journal_title：International journal of oncology

authors： Gridling M,Stark N,Madlener S,Lackner A,Popescu R,Benedek B,Diaz R,Tut FM,Nha Vo TP,Huber D,Gollinger M,Saiko P,Ozmen A,Mosgoeller W,De Martin R,Eytner R,Wagner KH,Grusch M,Fritzer-Szekeres M,Szekeres T,Kopp B,F

更新日期：2009-04-01 00:00:00

abstract：:Marek's disease virus (MDV) is one of the most oncogenic herpesviruses and the only cancer virus that has a successful vaccine. Based on the short-latency and polyclonal nature of the tumors, it is likely that MDV encodes its own oncogenes. Recent studies have provided insights into possible MDV genes involved in onco...

journal_title：International journal of oncology

authors： Kung H,Tanaka A,Nonoyama M

更新日期：1995-05-01 00:00:00

abstract：:A slowly proliferating cell fraction in tumors shows reduced sensitivity to cell cycle-dependent anticancer agents. To understand the molecular basis of drug resistance observed in brain tumors, we examined the relationship between alteration of p16, a cyclin dependent kinase inhibitor whose functions are frequently l...

journal_title：International journal of oncology

authors： Iwadate Y,Mochizuki S,Fujimoto S,Namba H,Sakiyama S,Tagawa M,Yamaura A

更新日期：2000-09-01 00:00:00

abstract：:The role and expression of ROCKI and ROCKII in human breast cancer was investigated and the effect on clinical outcome assessed. ROCK knockdown cells (MDA-MB-231DeltaROCKI and MDA-MB-231DeltaROCKII were tested for their in vitro invasiveness, motility and in vivo tumour growth. Samples of fresh frozen breast tumour ti...

journal_title：International journal of oncology

authors： Lane J,Martin TA,Watkins G,Mansel RE,Jiang WG

更新日期：2008-09-01 00:00:00

abstract：:Primary intracerebral lymphoma is an uncommon presenting site for non-Hodgkin's lymphoma. The authors review 28 histopathologically confirmed, consecutive cases, presenting over a 15-year period. The cohort included 20 males and 8 females with a mean age at diagnosis of 54 years (range 27-75 years). Subtotal resection...

journal_title：International journal of oncology

authors： Hough RE,Smith CM,Nakielny RA,Robinson MH,Jacubowski J,Lorigan PC,Hancock BW

更新日期：1999-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) were reported to be involved in the development of clear cell renal cell carcinoma (ccRCC). However, the study on miRNAs in ccRCC is far from complete. The present study identified miRNAs which could act as potential novel prognostic markers for ccRCC, and analyzed its possible mechanism. We found t...

journal_title：International journal of oncology

authors： Ma Q,Peng Z,Wang L,Li Y,Wang K,Zheng J,Liang Z,Liu T

更新日期：2016-12-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...

journal_title：International journal of oncology

authors： Tit-Oon P,Chokchaichamnankit D,Khongmanee A,Sawangareetrakul P,Svasti J,Srisomsap C

更新日期：2014-11-01 00:00:00

abstract：:Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...

journal_title：International journal of oncology

authors： Jung KH,Ryu YL,Lee HS,Lee H,Son MK,Yan HH,Hong SW,Ryu JK,Hong S,Suh JK,Hong SS

更新日期：2013-06-01 00:00:00

abstract：:We assessed Stanniocalcin-1 (STC-1) mRNA expression in human normal tissues, various types of human cancer cell lines, and cancer tissues obtained during surgery. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay developed to detect STC-1 mRNA, the transcripts were detected in 20 out of 21 cancer ...

journal_title：International journal of oncology

authors： Fujiwara Y,Sugita Y,Nakamori S,Miyamoto A,Shiozaki K,Nagano H,Sakon M,Monden M

更新日期：2000-04-01 00:00:00

abstract：:We have previously investigated the possibility of using hypericin as a diagnostic tool for the fluorescence detection of flat bladder carcinoma. In these clinical studies, it was shown that following intravesical application in humans, hypericin becomes selectively localized in transitional papillary carcinoma and ca...

journal_title：International journal of oncology

authors： Kamuhabwa AA,Roskams T,Baert L,De Witte PA

更新日期：2003-04-01 00:00:00

abstract：:We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...

journal_title：International journal of oncology

authors： Takahara Y,Yogosawa S,Maruyama S,Watanabe N,Yokoyama H,Fukasawa K,Sukenaga Y,Kamiyama J,Izumi M,Wakada M,Zhang H,Yoshizawa K,Kawa S,Nikaido T,Sakai T

更新日期：2006-04-01 00:00:00

abstract：:Drug-resistance is a major contributing factor for the poor prognosis in patients with pancreatic cancer. We have shown previously that the irreversible ErbB family blocker afatinib, is more effective than the reversible EGFR tyrosine kinase inhibitor erlotinib in inhibiting the growth of human pancreatic cancer cells...

journal_title：International journal of oncology

authors： Ioannou N,Seddon AM,Dalgleish A,Mackintosh D,Solca F,Modjtahedi H

更新日期：2016-03-01 00:00:00

abstract：:Hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC) is a global health problem that accounts for more than half of total liver cancer cases in developing countries. Despite the growing number of researches conducted, the molecular mechanism underlying the development of HCC remains elusive. Long non‑coding ...

journal_title：International journal of oncology

authors： Zhang H,Chen X,Zhang J,Wang X,Chen H,Liu L,Liu S

更新日期：2020-01-01 00:00:00

abstract：:RLIP76, a stress-responsive, multi-functional protein with multi-specific transport activity towards glutathione-conjugates (GS-E) and chemotherapeutic agents is frequently overexpressed in malignant cells. Our recent studies suggest that it plays a prominent anti-apoptotic role selectively in cancer cells. The presen...

journal_title：International journal of oncology

authors： Singhal SS,Sehrawat A,Mehta A,Sahu M,Awasthi S

更新日期：2009-01-01 00:00:00

abstract：:Toxicity of polyphenols against rat 3Y1 fibroblasts and the cells transformed by human adenovirus (Ad12-3Y1), its EIA gene (EIA-3Y1), or simian virus 40 (SV-3Y1) was examined. Among the diphenol compounds examined, pyrocatechol (o-diphenol) and hydroquinone (p-diphenol) showed selective toxicity against Ad12-3Y1 and E...

journal_title：International journal of oncology

authors： Yamada K,Mitsui T,Okuda A,Kimura G,Sugano M

更新日期：1993-01-01 00:00:00

abstract：:Neuroblastoma (NB) is one of the most common extracranial solid tumors in children, which has complex molecular mechanisms. Increasing evidence has suggested that long noncoding RNAs (lncRNAs) account for NB pathogenesis. However, the function of small nucleolar RNA host gene 16 (SNHG16) in NB is currently unclear. In...

journal_title：International journal of oncology

authors： Yu Y,Chen F,Yang Y,Jin Y,Shi J,Han S,Chu P,Lu J,Tai J,Wang S,Yang W,Wang H,Guo Y,Ni X

更新日期：2019-07-01 00:00:00

abstract：:MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...

journal_title：International journal of oncology

authors： Giannakouros P,Matte I,Rancourt C,Piché A

更新日期：2015-01-01 00:00:00

abstract：:Conceptually, dendritic cells (DCs) take up and process exogenous antigens that are presented on MHC (major histocompatibility complex) class II molecules to stimulate CD4+ T cells, and present endogenously-produced proteins to CD8+ T cells through an MHC class I-dependent pathway. In this study, we compared the antit...

journal_title：International journal of oncology

authors： Lacave R,Masurier C,Guigon M,Lemoine FM,Klatzmann D,Colombo BM

更新日期：2003-12-01 00:00:00

abstract：:Multiple drug resistance is reported to be a major obstacle in treatment of osteosarcoma (OS). Research has demonstrated that small subsets of cells called cancer stem cells (CSCs) are responsible for multiple drug resistance. CSCs are potential targets for reversing chemoresistance. In the present study, we compared ...

journal_title：International journal of oncology

authors： Shang D,Wu J,Guo L,Xu Y,Liu L,Lu J

更新日期：2017-05-01 00:00:00

abstract：:Lack of life-prolonging therapies has provided much of the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, the use of dietary supplements and botanical products has been showing a sustained increase in recent years, owing in part to some en...

journal_title：International journal of oncology

authors： Lu X,Hsieh TC,Wu JM

更新日期：2004-12-01 00:00:00