P53 expression in esophageal dysplasia - a possible biomarker for carcinogenesis of esophageal squamous-cell carcinoma.

Abstract:

:The tumor suppressor gene product p53 has been detected in a high percentage of esophageal squamous cell carcinoma. To evaluate the role of this protein in carcinogenesis, we examined the p53 overexpression both in esophageal dysplasia and in esophageal squamous cell carcinoma in the same patients. Using anti-p53 antibodies pAb1801 and CM-1, we analyzed immunohistochemically 36 dysplastic lesions from 36 patients with esophageal cancer. Nuclear p53 was detected in 14 of 36 dysplasias (39%). From mild to moderate to severe dysplasia, p53 positivity showed tendency to increase in number. Seventeen of the 36 squamous cell carcinomas showed p53 expression (47%). There was a significant concurrent p53 expression in esophageal dysplasia and its related squamous cell carcinoma (p=0.00345). These results indicate that p53 mutation is closely associated with the initiation of this cancer.

journal_name

Int J Oncol

authors

Maruyama K,Shiozaki H,Shimaya K,Inoue M,Iwazawa T,Matsui S,Mori T

doi

10.3892/ijo.4.5.1061

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

1061-5

issue

5

eissn

1019-6439

issn

1791-2423

journal_volume

4

pub_type

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