New aromatase inhibitors in the treatment of advanced breast cancer.

abstract：:CDH13 (H-cadherin) is a member of the cadherin superfamily, which plays an important role in cell recognition and adhesion. We examined the expression and methylation status of the CDH13 gene in diffuse large B cell lymphomas (B-DLCLs). We found decreased expression of the CDH13 gene in all of 6 hematopoietic cell lin...

journal_title：International journal of oncology

authors： Ogama Y,Ouchida M,Yoshino T,Ito S,Takimoto H,Shiote Y,Ishimaru F,Harada M,Tanimoto M,Shimizu K

更新日期：2004-09-01 00:00:00

abstract：:Although most hepatocellular carcinoma (HCC) is related to viral infection, there is a substantial population of HCC patients (5-20%) who are negative for both markers of hepatitis B virus and hepatitis C virus infection [non-B, non-C (NBNC) hepatitis] in Japan and the incidence of NBNC-HCC has recently tended to incr...

journal_title：International journal of oncology

authors： Nishikawa H,Osaki Y

更新日期：2013-11-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have realized that the images presented in Fig. 1A were selected erroneously (essentially, the images for group 'AdBMP9 +++' were chosen to represent the group 'AdGFP'). A corrected version of Fig. 1, including the correct data for the experiments depicte...

journal_title：International journal of oncology

authors： Wu N,Li R,Meng Z,Nie M,Chen Q,He B,Deng Z,Yin L

更新日期：2019-08-01 00:00:00

abstract：:ETS variant 1 (ETV1) is an oncogenic transcription factor. However, its role in colorectal cancer has remained understudied. The present study demonstrated that ETV1 downregulation led to reduced HCT116 colorectal cancer cell growth and clonogenic activity. Furthermore, the ETV1 mRNA levels were enhanced in colorectal...

journal_title：International journal of oncology

authors： Oh S,Song H,Freeman WM,Shin S,Janknecht R

更新日期：2020-12-01 00:00:00

abstract：:Reports of the metabolomic characteristics of esophageal cancer are limited. In the present study, we thus conducted metabolome analysis of paired tumor tissues (Ts) and non-tumor esophageal tissues (NTs) using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). The Ts and surrounding NTs were surgi...

journal_title：International journal of oncology

authors： Tokunaga M,Kami K,Ozawa S,Oguma J,Kazuno A,Miyachi H,Ohashi Y,Kusuhara M,Terashima M

更新日期：2018-06-01 00:00:00

abstract：:Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown o...

journal_title：International journal of oncology

authors： Sang Y,Sun L,Wu Y,Yuan W,Liu Y,Li SW

更新日期：2019-03-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome. We have previously reported that inhibitors of histone deacetylas...

journal_title：International journal of oncology

authors： Torres J,Regan PL,Edo R,Leonhardt P,Jeng EI,Rappaport EF,Ikegaki N,Tang XX

更新日期：2010-10-01 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most unfavorable prognostic tumor, and immediate growth and distant metastasis are important factors associated with the poor prognosis of patients with this disease. Standard and variant isoforms of CD44 are associated with tumor growth, metastasis, and epithelial-mesenchymal tr...

journal_title：International journal of oncology

authors： Miwa T,Nagata T,Kojima H,Sekine S,Okumura T

更新日期：2017-09-01 00:00:00

abstract：:Autoimmune diseases are the consequence of the immune system attack on the self. Autoimmunity, sometimes, is reflected through the production of autoantibodies to various self antigens leading to cellular malfunction or destruction. In the current study we employ such autoantibodies for the treatment of cancer origina...

journal_title：International journal of oncology

authors： Fishman P,Merimsky O,Shoenfeld Y

更新日期：1997-05-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00

abstract：:Globally, breast cancer in women is the leading cause of cancer death. This fact has generated an interest to obtain insight into breast tumorigenesis and also to develop drugs to control the disease. Ras is a proto-oncogene that is activated as a response to extracellular signals. As a member of the Ras GTPase superf...

journal_title：International journal of oncology

authors： Ponce-Cusi R,Calaf GM

更新日期：2016-02-01 00:00:00

abstract：:Many traditional healing plants successfully passed several hundred years of empirical testing against specific diseases and thereby demonstrating that they are well tolerated in humans. Although quite a few ethno-pharmacological plants are applied against a variety of conditions there are still numerous plants that h...

journal_title：International journal of oncology

authors： Gridling M,Stark N,Madlener S,Lackner A,Popescu R,Benedek B,Diaz R,Tut FM,Nha Vo TP,Huber D,Gollinger M,Saiko P,Ozmen A,Mosgoeller W,De Martin R,Eytner R,Wagner KH,Grusch M,Fritzer-Szekeres M,Szekeres T,Kopp B,F

更新日期：2009-04-01 00:00:00

abstract：:The aim of this study was to examine the level and basic characteristics of cell‑derived microparticles (MPs) in the cyst fluids of odontogenic keratocysts (OKCs). For this purpose, MPs from the cyst fluids (CFMPs) of OKCs were purified by a classic differential centrifugation method and characterized by a transmissio...

journal_title：International journal of oncology

authors： Man QW,Zhong WQ,Ren JG,Liu JY,Zheng YY,Li RF,Nyimi BF,Chen G,Zhao YF,Liu B

更新日期：2018-06-01 00:00:00

abstract：:On the basis of immunological results, it is not in doubt that the immune system is able to recognize and eliminate transformed cells. A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and ...

journal_title：International journal of oncology

authors： Scutti JAB

更新日期：2018-04-01 00:00:00

abstract：:The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid malignant tumors to alter the microenvironment represents an important characteristic through which tumor cells are able t...

journal_title：International journal of oncology

authors： Zhang X,Huang S,Guo J,Zhou L,You L,Zhang T,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A, and demonstrated up-regulation of WNT10A in gastric cancer. Here, we investigated expression of WNT10A mRNA in various types of human cancer. WNT10A mRNA was detected in 10 out of 12 esophageal ...

journal_title：International journal of oncology

authors： Kirikoshi H,Inoue S,Sekihara H,Katoh M

更新日期：2001-11-01 00:00:00

abstract：:The tumor suppressor gene product p53 has been detected in a high percentage of esophageal squamous cell carcinoma. To evaluate the role of this protein in carcinogenesis, we examined the p53 overexpression both in esophageal dysplasia and in esophageal squamous cell carcinoma in the same patients. Using anti-p53 anti...

journal_title：International journal of oncology

authors： Maruyama K,Shiozaki H,Shimaya K,Inoue M,Iwazawa T,Matsui S,Mori T

更新日期：1994-05-01 00:00:00

abstract：:Autocrine fibroblast growth factor (FGF) signaling was genetically manipulated in human gliomas by an adenovirus-mediated strategy. Antisense inhibition of endogenous basic FGF (bFGF) expression showed inhibition of the proliferation of human glioma cells (U251MG, NMC-G1) without promoting apoptosis. The reduction in ...

journal_title：International journal of oncology

authors： Aoki T,Kato S,Fox JC,Okamoto K,Sakata K,Morimatsu M,Shigemori M

更新日期：2002-09-01 00:00:00

abstract：:Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...

journal_title：International journal of oncology

authors： Jatoi A,Foster NR,Egner JR,Burch PA,Stella PJ,Rubin J,Dakhil SR,Sargent DJ,Murphy BR,Alberts SR

更新日期：2010-03-01 00:00:00

abstract：:The treatment of glioblastoma is unsatisfactory. Improved understanding of the biological effects of treatment, together with development of new tools to predict outcome of the initiated treatment are therefore of great need. Vandetanib (ZD6474) is mainly a vascular endothelial growth factor (VEGF) and epidermal growt...

journal_title：International journal of oncology

authors： Wibom C,Sandström M,Henriksson R,Antti H,Johansson M,Bergenheim AT

更新日期：2010-10-01 00:00:00

abstract：:We have previously shown that the combination of allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) using CD4+ cell-depleted spleen cells is effective in suppressing tumor growth, but that this does not induce graft-versus-host disease (GVHD) in mice. In this report,...

journal_title：International journal of oncology

authors： Mukaide H,Adachi Y,Koike-Kiriyama N,Suzuki Y,Minamino K,Iwasaki M,Tsuda M,Nakano K,Koike Y,Shigematsu A,Kamiyama Y,Ikehara S

更新日期：2007-06-01 00:00:00

abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

journal_title：International journal of oncology

authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

更新日期：2006-01-01 00:00:00

abstract：:Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...

journal_title：International journal of oncology

authors： Pereira MC,de Bessa-Garcia SA,Burikhanov R,Pavanelli AC,Antunes L,Rangnekar VM,Nagai MA

更新日期：2013-08-01 00:00:00

abstract：:Medulloblastoma is the most common malignant brain tumor in childhood. The most prevalent chromosomal abnormalities are isochromosome 17q and loss of 17p, the location of the tumor suppressor gene p53. Mutations in the p53 gene in medulloblastoma are relatively infrequent but have recently been correlated to poor prog...

journal_title：International journal of oncology

authors： Philipova T,Baryawno N,Hartmann W,Pietsch T,Druid H,Johnsen JI,Ekström TJ

更新日期：2011-03-01 00:00:00

abstract：:This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, which was originally gefitinib...

journal_title：International journal of oncology

authors： Terai H,Soejima K,Yasuda H,Sato T,Naoki K,Ikemura S,Arai D,Ohgino K,Ishioka K,Hamamoto J,Kanai Y,Betsuyaku T

更新日期：2015-01-01 00:00:00

abstract：:A monoclonal antibody (MSN-3) was raised using HEC-108 cells derived from poorly differentiated endometrial carcinoma as the immunogen. The immunoglobulin subclass of MSN-3 was IgGr1. The target antigen of MSN-3 was a protein with a molecular weight of 77 kDa, and it was shown to be localized in the cytoplasm. MSN-3 o...

journal_title：International journal of oncology

authors： Hasegawa K,Tsukazaki K,Kubushiro K,Kobayashi Y,Kobiki K,Udagawa Y,Nozawa S

更新日期：1997-10-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against several human cancer cell lines. In the present study, we investigated further possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured...

journal_title：International journal of oncology

authors： Park C,Jung JH,Kim ND,Choi YH

更新日期：2007-01-01 00:00:00

abstract：:The enzyme poly(ADP-ribose)polymerase (PARP) has been implicated in several cellular processes by the demonstration of ADP-ribosylation of proteins which play a role in cellular repair of DNA damage, response to ionizing radiation and apoptosis. In addition, ADP-ribosylation has been shown to play a role in cell cycle...

journal_title：International journal of oncology

authors： Ramsamooj P,Prasad S,Dritschilo A,Notario V

更新日期：1996-04-01 00:00:00