Isoform switch of CD44 induces different chemotactic and tumorigenic ability in gallbladder cancer.

abstract：:We examined the clinical significance of E-cadherin and vimentin expression in 83 patients with breast dancer. E-cadherin expression was correlated with axillary metastases, histologic grade, recurrence and disease-free survival, but not with overall survival. On the other hand, vimentin expression was correlated with...

journal_title：International journal of oncology

authors： Yagasaki R,Noguchi M,Minami M,Earashi M

更新日期：1996-10-01 00:00:00

abstract：:A disintegrin and metalloproteinase-17 (ADAM17) can cut and release a wide variety of epidermal growth factor receptor (EGFR) ligands to promote survival, invasion and proliferation of cancer cell, and therefore, is considered to be a potential therapeutic target for cancer. The main goal of the present study was to o...

journal_title：International journal of oncology

authors： Meng X,Hu B,Hossain MM,Chen G,Sun Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...

journal_title：International journal of oncology

authors： Huang Z,McWilliams A,Lam S,English J,McLean DI,Lui H,Zeng H

更新日期：2003-09-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have realized that the images presented in Fig. 1A were selected erroneously (essentially, the images for group 'AdBMP9 +++' were chosen to represent the group 'AdGFP'). A corrected version of Fig. 1, including the correct data for the experiments depicte...

journal_title：International journal of oncology

authors： Wu N,Li R,Meng Z,Nie M,Chen Q,He B,Deng Z,Yin L

更新日期：2019-08-01 00:00:00

abstract：:Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in r...

journal_title：International journal of oncology

authors： Tsukamoto S,Honoki K,Fujii H,Tohma Y,Kido A,Mori T,Tsujiuchi T,Tanaka Y

更新日期：2012-01-01 00:00:00

abstract：:The present in vitro study on three human renal cell carcinoma (RCC) cell lines (A-498, ACHN, SN12C) evaluated the efficacy of 2',2'-difluorodeoxycytidine (dFdC, gemcitabine), vinblastine (VBL), rhu-interferon-alpha (IFN-alpha) and rhu-interferon-gamma (IFN-gamma) alone or in combinations. The cytotoxicity was measure...

journal_title：International journal of oncology

authors： Rohde D,Hayn HK,Blatter J,Jakse G

更新日期：1998-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism un...

journal_title：International journal of oncology

authors： Morita Y,Hata K,Nakanishi M,Nishisho T,Yura Y,Yoneda T

更新日期：2012-09-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. F...

journal_title：International journal of oncology

authors： Takeda K,Tomimori K,Kimura R,Ishikawa C,Nowling TK,Mori N

更新日期：2012-01-01 00:00:00

abstract：:The support mechanisms that are involved in lymph-node metastasis of oral squamous cell carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. In this study, we examined...

journal_title：International journal of oncology

authors： Ishikawa T,Nakashiro K,Hara S,Klosek SK,Li C,Shintani S,Hamakawa H

更新日期：2006-01-01 00:00:00

abstract：:Recently, the inflammatory cytokine IL-6 has been reported as a potent inducer of epithelial-mesenchymal transition (EMT) in breast cancer cells with an epithelial phenotype. Furthermore, EMT induces stem cell features in normal and transformed mammary cells. We explored whether IL-...

journal_title：International journal of oncology

authors： Xie G,Yao Q,Liu Y,Du S,Liu A,Guo Z,Sun A,Ruan J,Chen L,Ye C,Yuan Y

更新日期：2012-04-01 00:00:00

abstract：:We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which cont...

journal_title：International journal of oncology

authors： Gutierrez M,Bhatia K,Diez B,Muriel F,Epelman S,Deandreas M,Huppi K,Magrath I

更新日期：1994-03-01 00:00:00

abstract：:Ewing's sarcoma (ES) is a rare tumor that is more frequent in pediatric and adolescent age groups. In the past few decades, long-term survival in affected patients has improved due to the success of multimodal therapy. However, long-term survival is inevitably restricted by the late side-effects of chemotherapy. Besid...

journal_title：International journal of oncology

authors： Ye C,Yu X,Zeng J,Dai M,Zhang B

更新日期：2017-12-01 00:00:00

abstract：:Thymidine kinase (TK) activity in rat hepatoma JB1 and AH136B was mainly due to cytosolic TK and was much higher than that in rat regenerating liver. Two forms of cytosolic TK, designated as TK-I and TK-II, were revealed in addition to mitochondrial TK in anion-exchange high performance liquid chromatography (HPLC) of...

journal_title：International journal of oncology

authors： Lin L,Islam MM,Du M,Ohmura Y,Hiwasa T,Fujimura S

更新日期：1999-08-01 00:00:00

abstract：:From January 1992 to December 1995, 129 patients with previously untreated non-Hodgkin's lymphoma were randomised in a phase III multicenter trial to receive CEOP-B/VIMB or ProMACE-CytaBOM. Eligibility criteria included intermediate or high grade lymphoma (follicular large cell, diffuse small cleaved-cell, diffuse mix...

journal_title：International journal of oncology

authors： Lorusso V,Palmieri G,Bianco AR,Abate G,Catalano G,De Vita F,Dammacco F,Lauta VM,Lucarelli G,Polimeno G,Mantovani G,D'Aprile M,Marzullo F,De Lena M

更新日期：2000-01-01 00:00:00

abstract：:We previously reported in a retrospective study that CEA-based RT-PCR was useful for predicting the prognosis of patients with node-negative colorectal cancer. RT-PCR is well established for laboratory use, but many issues remain to be resolved prior to its clinical application. In addition to the false positive rate ...

journal_title：International journal of oncology

authors： Takayama O,Yamamoto H,Ikeda K,Ishida H,Kato T,Okuyama M,Kanou T,Fukunaga M,Tominaga S,Morita S,Fujie Y,Fukunaga H,Ikenaga M,Ikeda M,Ohue M,Sekimoto M,Kikkawa N,Monden M

更新日期：2004-09-01 00:00:00

abstract：:Claudin 6 (CLDN6), a member of tight junction protein claudin (CLDN) family, inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. However, these molecular mechanisms of CLDN6-induced apoptosis remain largely elusive. We previously found that restoration of human CLDN6 gene expression was correlat...

journal_title：International journal of oncology

authors： Guo Y,Lin D,Zhang M,Zhang X,Li Y,Yang R,Lu Y,Jin X,Yang M,Wang M,Zhao S,Quan C

更新日期：2016-06-01 00:00:00

abstract：:Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

journal_title：International journal of oncology

authors： Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

更新日期：2005-02-01 00:00:00

abstract：:Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations. Previous studies suggested that imatinib mesylate (Gleevec) is effective in pre-clinical trials for glioblastoma. Also, chlorimipramine (Anafranil) is an anti-depressant drug in use in the clinic and ...

journal_title：International journal of oncology

authors： Bilir A,Erguven M,Oktem G,Ozdemir A,Uslu A,Aktas E,Bonavida B

更新日期：2008-04-01 00:00:00

abstract：:DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to be elucidated. In current study, using the publicly available lu...

journal_title：International journal of oncology

authors： Wang M,Xie S,Yuan W,Xie T,Jamal M,Huang J,Yin Q,Song H,Zhang Q

更新日期：2019-12-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

journal_title：International journal of oncology

authors： Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

更新日期：2016-08-01 00:00:00

abstract：:MicroRNA (miRNA)-126 (miR-126) was reported to be downregulated and to act as a tumor suppressor in cancers of the lung, cervix, bladder and prostate. However, the functions of miR-126 in gastric cancer appear to be diverse and are largely unknown. MiR-126 was reported to act as a tumor suppressor by targeting the Crk...

journal_title：International journal of oncology

authors： Liu LY,Wang W,Zhao LY,Guo B,Yang J,Zhao XG,Hou N,Ni L,Wang AY,Song TS,Huang C,Xu JR

更新日期：2014-09-01 00:00:00

abstract：:Three major, fast developing lines of research are elucidating the biology of the mammary gland and its malignant transformation: phenotypical analyses of epithelial cells and mammary proliferative lesions, the identification, purification and characterization of mammary stem cells and breast cancer-initiating cells, ...

journal_title：International journal of oncology

authors： Birnbaum D,Bertucci F,Ginestier C,Tagett R,Jacquemier J,Charafe-Jauffret E

更新日期：2004-08-01 00:00:00

abstract：:Hexadecylphosphocholine (HPC, D-18506, INN: Miltefosine) was characterized in a clonogenic micro assay in vitro with respect to its cytotoxicity against a panel of human and murine tumor cell lines and murine bone marrow cultures (GM-CFC). The KB human epithelial carcinoma line was found to be more sensitive by at lea...

journal_title：International journal of oncology

authors： Voegeli R,Echarti C,Maurer H,Stekar J,Hilgard P,Unger C

更新日期：1993-02-01 00:00:00

abstract：:The enzyme poly(ADP-ribose)polymerase (PARP) has been implicated in several cellular processes by the demonstration of ADP-ribosylation of proteins which play a role in cellular repair of DNA damage, response to ionizing radiation and apoptosis. In addition, ADP-ribosylation has been shown to play a role in cell cycle...

journal_title：International journal of oncology

authors： Ramsamooj P,Prasad S,Dritschilo A,Notario V

更新日期：1996-04-01 00:00:00

abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

journal_title：International journal of oncology

authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

更新日期：2002-06-01 00:00:00

abstract：:The DNA topoisomerase I inhibitor beta-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of beta-lapachone on the growth of human prostate epithelial cells. Upon treatment with beta-lapachon...

journal_title：International journal of oncology

authors： Choi YH,Kim MJ,Lee SY,Lee YN,Chi GY,Eom HS,Kim ND,Choi BT

更新日期：2002-12-01 00:00:00