Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages.

abstract：:Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...

journal_title：International journal of oncology

authors： Pereira MC,de Bessa-Garcia SA,Burikhanov R,Pavanelli AC,Antunes L,Rangnekar VM,Nagai MA

更新日期：2013-08-01 00:00:00

abstract：:Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. F...

journal_title：International journal of oncology

authors： Papadakis E,Malliri A,Linardopoulos S,Karaiossifidi H,Field J,Spandidos D

更新日期：1992-09-01 00:00:00

abstract：:Previous investigations have shown that interleukin-11 (IL-11) and the IL-11 receptor (IL-11R) have been correlated with the regulation of tumor progression, cellular growth and differentiation in several malignant tumors. The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric ...

journal_title：International journal of oncology

authors： Nakayama T,Yoshizaki A,Izumida S,Suehiro T,Miura S,Uemura T,Yakata Y,Shichijo K,Yamashita S,Sekin I

更新日期：2007-04-01 00:00:00

abstract：:Telomerase activity was studied in 51 penile carcinomas, and detected in all samples from 3 patients with verrucous carcinoma, in 85.4% (41/48) of invasive carcinomas, in 81.8% (9/11) of adjacent non-cancerous skin and in 80% (8/10) of adjacent non-cancerous corpus cavernosum. All skin and corpus cavernosum samples fr...

journal_title：International journal of oncology

authors： Alves G,Fiedler W,Guenther E,Nascimento P,Campos MM,Ornellas AA

更新日期：2001-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the performance of whole-body diffusion-weighted imaging (WB-DWI), whole-body positron emission tomography with computed tomography (WB-PET/CT), and whole-body positron emission tomography with magnetic resonance imaging (WB-PET/MRI) in staging patients with untreated invas...

journal_title：International journal of oncology

authors： Catalano OA,Daye D,Signore A,Iannace C,Vangel M,Luongo A,Catalano M,Filomena M,Mansi L,Soricelli A,Salvatore M,Fuin N,Catana C,Mahmood U,Rosen BR

更新日期：2017-07-01 00:00:00

abstract：:A group of 133 primary oral squamous cell carcinomas were studied concerning a relationship between exposure factors and tumour biological parameters with a focus on the TP53 gene and p53 protein status. Tumours were evaluated using immunohistochemistry (IHC) for expression of p53, PCNA, Ki-67 and bcl-2 proteins. The ...

journal_title：International journal of oncology

authors： Schildt EB,Nylander K,Eriksson M,Hardell L,Magnusson A,Roos G

更新日期：2003-04-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...

journal_title：International journal of oncology

authors： He DX,Zhang GY,Gu XT,Mao AQ,Lu CX,Jin J,Liu DQ,Ma X

更新日期：2016-10-01 00:00:00

abstract：:The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line. SEM cells were injected into the tail vein and engraftment was monitored ...

journal_title：International journal of oncology

authors： Zunino SJ,Storms DH,Newman JW,Pedersen TL,Keen CL,Ducore JM

更新日期：2012-04-01 00:00:00

abstract：:The suppressors of cytokine signaling (SOCS) family inhibits not only Janus kinase (JAK)/signal transducers and activators of transcription (STAT) but also focal adhesion kinase (FAK) signaling pathways, and has tumor suppressor activity. Aberrant methylation in the promoter region of the SOCS3 gene frequently occurs ...

journal_title：International journal of oncology

authors： Tokita T,Maesawa C,Kimura T,Kotani K,Takahashi K,Akasaka T,Masuda T

更新日期：2007-03-01 00:00:00

abstract：:Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear matrix proteins during HMBA-induced differentiation of human...

journal_title：International journal of oncology

authors： Xu DH,Liu F,Li X,Chen XF,Jing GJ,Wu FY,Shi SL,Li QF

更新日期：2014-07-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological cancer. We identified interleukin 11 (IL11) as a critical mediator of endometrial tumourigenesis and demonstrated that IL11 regulates chondroitin sulfate proteoglycan (CSPG4) in human placental trophoblasts. CSPG4 is a cell membrane protein overexpressed in numerous ...

journal_title：International journal of oncology

authors： Winship A,Van Sinderen M,Heffernan-Marks A,Dimitriadis E

更新日期：2017-03-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...

journal_title：International journal of oncology

authors： Otsuki T,Fujimoto D,Hirono Y,Goi T,Yamaguchi A

更新日期：2014-12-01 00:00:00

abstract：:Licochalcone A (LCA) is a natural product derived from the roots of Glycyrrhiza inflata exhibiting a wide range of bioactivities such as antitumor, anti-oxidant and anti-bacterial effects. Malignant pleural mesothelioma (MPM) is an extremely aggressive type of cancer with a poor prognosis because of its rapid progress...

journal_title：International journal of oncology

authors： Kim KH,Yoon G,Cho JJ,Cho JH,Cho YS,Chae JI,Shim JH

更新日期：2015-03-01 00:00:00

abstract：:Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...

journal_title：International journal of oncology

authors： Ahmad SS,Glatzle J,Bajaeifer K,Bühler S,Lehmann T,Königsrainer I,Vollmer JP,Sipos B,Ahmad SS,Northoff H,Königsrainer A,Zieker D

更新日期：2013-08-01 00:00:00

abstract：:We have previously shown that the genotoxin-induced apoptosis in mouse embryo fibroblasts was enhanced by the extracellular matrix protein fibronectin (FN). In the present study, we tested the hypothesis that FN regulates the DNA damage response (DDR) signaling pathways in HCT116 (p53-wt) and HT29 (p53-mut) human colo...

journal_title：International journal of oncology

authors： DE Wever O,Sobczak-Thépot J,Vercoutter-Edouart AS,Michalski JC,Ouelaa-Benslama R,Stupack DG,Bracke M,Wang JYJ,Gespach C,Emami S

更新日期：2011-08-01 00:00:00

abstract：:The modifying effects of dietary administration of capsaicin, which is the principal pungent capsicum fruit, and rotenone, which is a naturally occurring pesticide derived from Derris and Lonchorcarpus species, on azoxymethane (AOM)-induced colon tumorigenesis were investigated in male F344 rats. Gavage with capsaicin...

journal_title：International journal of oncology

authors： Yoshitani SI,Tanaka T,Kohno H,Takashima S

更新日期：2001-11-01 00:00:00

abstract：:Protein kinase C (PKC) designates a family of kinases that regulate many essential functions including cell growth and differentiation. The tight regulation of PKC activity is crucial for maintaining normal cellular proliferation and excessive activity leads to abnormal or uncontrolled cell growth. Recent reports indi...

journal_title：International journal of oncology

authors： Sharif TR,Sharif M

更新日期：1999-02-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...

journal_title：International journal of oncology

authors： Thews O,Lambert C,Kelleher DK,Biesalski HK,Vaupel P,Frank J

更新日期：2005-09-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against several human cancer cell lines. In the present study, we investigated further possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured...

journal_title：International journal of oncology

authors： Park C,Jung JH,Kim ND,Choi YH

更新日期：2007-01-01 00:00:00

abstract：:Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon alpha (IFN-alpha) as a single agent or combined with standard chemo-therapy has been shown to inhibit various tumors, but the effect of combination anti-angiog...

journal_title：International journal of oncology

authors： Son MJ,Song HS,Kim MH,Kim JT,Kang CM,Jeon JW,Park SY,Kim YJ,Groves MD,Park K,Kim JH,Nam DH

更新日期：2006-06-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...

journal_title：International journal of oncology

authors： Chen J,Schmitt A,Giannopoulos K,Chen B,Rojewski M,Döhner H,Bunjes D,Schmitt M

更新日期：2007-11-01 00:00:00

abstract：:Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying development of multidrug-resistance in NB we established two neuroblastoma cell sublines resistant to vincristine (UKF-NB-3rVCR10) and doxorubicin (UKF-NB-3rDOX20...

journal_title：International journal of oncology

authors： Kotchetkov R,Driever PH,Cinatl J,Michaelis M,Karaskova J,Blaheta R,Squire JA,Von Deimling A,Moog J,Cinatl J Jr

更新日期：2005-10-01 00:00:00

abstract：:Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and p...

journal_title：International journal of oncology

authors： Haneji T,Hirashima K,Teramachi J,Morimoto H

更新日期：2013-06-01 00:00:00

abstract：:Human mammary and thyroid tumors as well as peripheral blood cells of the same patients were examined for the amplification of oncogene fins and the expression of its product. Of the 7 mammary tumors analyzed, amplification of fms was observed in 6 (86%) mammary tumor DNAs, while no amplification was seen in 5 thyroid...

journal_title：International journal of oncology

authors： Haga S,Imai S,Morimoto J,Okumoto M,Nishikawa R,Mori N,Kiyozuka Y,Nagano K,Nishino T,Yamamoto H,Sarkar N

更新日期：1994-10-01 00:00:00

abstract：:The retinoic acid receptor (RAR) beta gene is located in a region on chromosome 3p, which is frequently deleted in renal cell carcinoma. Since retinoic acid (RA) can inhibit cell proliferation and tumor formation, loss of RAR beta might contribute to oncogenesis of the kidney. This prompted us to examine RAR beta expr...

journal_title：International journal of oncology

authors： Vanderleede B,Opdenoordt T,Vandenbrink C,Ebert T,Vandersaag P

更新日期：1995-02-01 00:00:00

abstract：:Normal cells produce energy either through OXPHOS in the presence of oxygen or glycolysis in its absence. Cancer cells produce energy preferably through glycolysis even in the presence of oxygen, thereby, acquiring survival and proliferative advantages. Oncogenes and tumour suppressors control these metabolic pathways...

journal_title：International journal of oncology

authors： Rajendran R,Garva R,Ashour H,Leung T,Stratford I,Krstic-Demonacos M,Demonacos C

更新日期：2013-06-01 00:00:00

abstract：:5-Fluorouracil (5-FU), a fluoropyrimidine analogue, is one of the most commonly used anticancer drugs for the treatment of gastrointestinal malignancies. Some studies reported that the cytotoxicity of fluoropyrimidines is mediated, in large part, by inhibition of the thymidylate synthase (TS), an essential DNA synthet...

journal_title：International journal of oncology

authors： Matsuoka K,Tsukuda K,Suda M,Kobayashi K,Ota T,Okita A,Watanabe K,Suzuki E,Murakami M,Doihara H,Shimizu N

更新日期：2004-01-01 00:00:00

abstract：:Percutaneous nephrostomy (PN) will rapidly correct renal failure due to ureteral obstruction. Complications of the procedure are few and the procedure can be quickly accomplished on an outpatient basis using local anesthesia. A retrospective review of fifty patients who underwent PN led to derivation of a formula whic...

journal_title：International journal of oncology

authors： McKenna B,Chalas E,Ferretti J,Rothpearl A,Mann W

更新日期：1994-04-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00