Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

Abstract:

:Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. Fifteen cases of benign lessions were also assessed for both ras p21 and p53 expression; all were found to have negative staining. p53 over-expression was found to correlate with a poor prognosis in both the tumor specimens (p<0.05) and in the nodal tissues (p<0.005). Ras p21 over-expression was found to be associated with survival (p<0.1) in both the tumor and the nodal specimens. Stage of the disease correlated with survival; similarly both p53 and ras p21 over-expression correlated with stage. No correlations were found with the pathological grade of the tumors nor with a history of smoking or duration of smoking. No K-ras mutations at codon 12 were observed in a further 15 NSCLC specimens analyzed. These results indicate that the p53 gene in particular plays a role in the stages of NSCLC.

journal_name

Int J Oncol

authors

Papadakis E,Malliri A,Linardopoulos S,Karaiossifidi H,Field J,Spandidos D

doi

10.3892/ijo.1.4.403

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

403-13

issue

4

eissn

1019-6439

issn

1791-2423

journal_volume

1

pub_type

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