Determination of telomerase activity in squamous cell carcinoma of the penis.

Abstract:

:Telomerase activity was studied in 51 penile carcinomas, and detected in all samples from 3 patients with verrucous carcinoma, in 85.4% (41/48) of invasive carcinomas, in 81.8% (9/11) of adjacent non-cancerous skin and in 80% (8/10) of adjacent non-cancerous corpus cavernosum. All skin and corpus cavernosum samples from patients with prostatic carcinoma were found to be telomerase negative. Our results indicate a correlation between frequency of telomerase activity and grade of penile carcinoma. The finding of telomerase activity in skin and corpus cavernosum samples adjacent to tumor suggests that unidentified local factors may modulate telomerase activity in normal tissues.

journal_name

Int J Oncol

authors

Alves G,Fiedler W,Guenther E,Nascimento P,Campos MM,Ornellas AA

doi

10.3892/ijo.18.1.67

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

67-70

issue

1

eissn

1019-6439

issn

1791-2423

journal_volume

18

pub_type

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