Abstract:
:Telomerase activity was studied in 51 penile carcinomas, and detected in all samples from 3 patients with verrucous carcinoma, in 85.4% (41/48) of invasive carcinomas, in 81.8% (9/11) of adjacent non-cancerous skin and in 80% (8/10) of adjacent non-cancerous corpus cavernosum. All skin and corpus cavernosum samples from patients with prostatic carcinoma were found to be telomerase negative. Our results indicate a correlation between frequency of telomerase activity and grade of penile carcinoma. The finding of telomerase activity in skin and corpus cavernosum samples adjacent to tumor suggests that unidentified local factors may modulate telomerase activity in normal tissues.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Alves G,Fiedler W,Guenther E,Nascimento P,Campos MM,Ornellas AAdoi
10.3892/ijo.18.1.67keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
67-70issue
1eissn
1019-6439issn
1791-2423journal_volume
18pub_type
杂志文章abstract::Signet ring cell gastric cancer (SRCGC) has very poor prognosis worldwide, and studying its molecular characteristics is urgent for improving the outcome. However, few well-characterized SRCGC cell lines are available for research. Therefore, we established a novel cell line GCSR1, from a Chinese male SRCGC patient. C...
journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000421
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abstract::Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...
journal_title:International journal of oncology
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更新日期:2002-09-01 00:00:00
abstract::Cell lines established from the TH-MYCN transgenic murine model of neuroblastoma are a valuable preclinical, immunocompetent, syngeneic model of neuroblastoma, for which knowledge of their p53 pathway status is important. In this study, the Trp53 status and functional response to Nutlin-3 and ionising radiation (IR) w...
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abstract::The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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更新日期:1994-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1382
更新日期:2012-06-01 00:00:00
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更新日期:2013-07-01 00:00:00
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更新日期:2016-08-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.2013.2182
更新日期:2014-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2019-07-01 00:00:00
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journal_title:International journal of oncology
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doi:
更新日期:2005-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2005-08-01 00:00:00
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更新日期:2008-08-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2001-08-01 00:00:00
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更新日期:2007-03-01 00:00:00
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