Synergistic effect and condition of pegylated interferon alpha with paclitaxel on glioblastoma.

abstract：:Tetramethypyrazine (TMP), one of the active compounds extracted from the traditional Chinese medicinal herb (Chuanxiong), has been verified as an anticancer compound against several types of cancer. However, understanding of the molecular mechanisms have not been fully elucidated. In the present study, the anticancer ...

journal_title：International journal of oncology

authors： Luan Y,Liu J,Liu X,Xue X,Kong F,Sun C,Wang J,Liu L,Jia H

更新日期：2016-10-01 00:00:00

abstract：:We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-...

journal_title：International journal of oncology

authors： Yoshida H,Enomoto H,Miyauchi M,Takenaga K,Tanabe M,Ohnuma N,Sakiyama S,Tagawa M

更新日期：1998-05-01 00:00:00

abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

journal_title：International journal of oncology

authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

更新日期：1993-04-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associ...

journal_title：International journal of oncology

authors： Zeng H,Xu N,Liu Y,Liu B,Yang Z,Fu Z,Lian C,Guo H

更新日期：2017-08-01 00:00:00

abstract：:Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...

journal_title：International journal of oncology

authors： Fritz G,Issinger OG,Olsen BB

更新日期：2009-11-01 00:00:00

abstract：:Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...

journal_title：International journal of oncology

authors： Tennstedt P,Köster P,Brüchmann A,Mirlacher M,Haese A,Steuber T,Sauter G,Huland H,Graefen M,Schlomm T,Minner S,Simon R

更新日期：2012-01-01 00:00:00

abstract：:Mutations in p53 are the most common genetic abnormality in cancers. Arsenic trioxide (ATO) is an effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia (APL) and is being tested in phase II studies in various types of cancers. We have shown that ATO is a potent inducer of apoptosis in mult...

journal_title：International journal of oncology

authors： Kircelli F,Akay C,Gazitt Y

更新日期：2007-04-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are potentially mutagenic/carcinogenic lesions. Induction of DSBs triggers phosphorylation of histone H2AX on Ser-139. Phosphorylated H2AX (gammaH2AX) can be detected immunocytochemically, and the intensity of gammaH2AX immunofluorescence (IF), reflecting the number of gammaH2AX-IF foci...

journal_title：International journal of oncology

authors： Albino AP,Huang X,Jorgensen ED,Gietl D,Traganos F,Darzynkiewicz Z

更新日期：2006-06-01 00:00:00

abstract：:This study suggests that speckle-type POZ protein (SPOP) may be a tumor suppressor gene and its prognostic value in human glioma. Real-time quantitative RT-PCR (qRT‑PCR), western blotting, and immunohistochemical staining were used to examine SPOP expression in glioma tissues and normal brain (NB) tissues. The relatio...

journal_title：International journal of oncology

authors： Ding D,Song T,Jun W,Tan Z,Fang J

更新日期：2015-01-01 00:00:00

abstract：:The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...

journal_title：International journal of oncology

authors： Chow LS,Wang X,Kwong DL,Sham JS,Tsao SW,Nicholls JM

更新日期：2000-07-01 00:00:00

abstract：:Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not wel...

journal_title：International journal of oncology

authors： Borrego-Diaz E,Powers BC,Azizov V,Lovell S,Reyes R,Chapman B,Tawfik O,McGregor D,Diaz FJ,Wang X,Veldhuizen PV

更新日期：2014-12-01 00:00:00

abstract：:Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell l...

journal_title：International journal of oncology

authors： Habibie,Yokoyama S,Abdelhamed S,Awale S,Sakurai H,Hayakawa Y,Saiki I

更新日期：2014-08-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00

abstract：:The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...

journal_title：International journal of oncology

authors： Lee WS,Park YL,Kim N,Oh HH,Son DJ,Kim MY,Oak CY,Chung CY,Park HC,Kim JS,Myung DS,Cho SB,Joo YE

更新日期：2015-05-01 00:00:00

abstract：:Chromosomal alterations are a major genomic force contributing to the development of lung cancer. We subjected 22 cases of squamous cell carcinoma of the lung (SCC) to whole-genome microarray-CGH (resolution, 1 Mb) to identify critical genetic landmarks that might be important mediators in the formation or progression...

journal_title：International journal of oncology

authors： Kang JU,Koo SH,Kwon KC,Park JW

更新日期：2010-08-01 00:00:00

abstract：:To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5/F35 adenoviral vector did not exhibit any significant enhancement of transduction efficien...

journal_title：International journal of oncology

authors： Kim SY,Kang S,Song JJ,Kim JH

更新日期：2013-04-01 00:00:00

abstract：:Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine ...

journal_title：International journal of oncology

authors： Galimberti F,Busch AM,Chinyengetere F,Ma T,Sekula D,Memoli VA,Dragnev KH,Liu F,Johnson KC,Guo Y,Freemantle SJ,Andrew AS,Greninger P,Robbins DJ,Settleman J,Benes C,Dmitrovsky E

更新日期：2012-11-01 00:00:00

abstract：:The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...

journal_title：International journal of oncology

authors： Gao Y,Li L,Li T,Ma L,Yuan M,Sun W,Cheng HL,Niu L,Du Z,Quan Z,Fan Y,Fan J,Luo C,Wu X

更新日期：2019-06-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:Clinicopathological assessment of the functional relationship between the HER2 oncogene and tumor-associated fatty acid synthase (FASN) is largely precluded because immunohistochemical and/or mRNA studies should be performed in biopsies from breast cancer patients. We here sought to determine whether serum FASN (sFASN...

journal_title：International journal of oncology

authors： Vazquez-Martin A,Fernandez-Real JM,Oliveras-Ferraros C,Navarrete JM,Martin-Castillo B,Del Barco S,Brunet J,Menendez JA

更新日期：2009-12-01 00:00:00

abstract：:Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerob...

journal_title：International journal of oncology

authors： Xu H,Zeng Y,Liu L,Gao Q,Jin S,Lan Q,Lai W,Luo X,Wu H,Huang Y,Chu Z

更新日期：2017-10-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a key growth factor linked to promoting cancer progression and angiogenesis. The present study identifies repulsive guidance molecule b (RGMb), a bone morphogenetic protein (BMP) co-receptor, as a gene whose expression is regulated by HGF and explores the potential of RGMb to contribu...

journal_title：International journal of oncology

authors： Sanders AJ,Ye L,Li J,Mason MD,Jiang WG

更新日期：2014-09-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：International journal of oncology

authors： Navolanic PM,McCubrey JA

更新日期：2005-11-01 00:00:00

abstract：:Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most impor...

journal_title：International journal of oncology

authors： Kawamoto S,Moriwaki K,Nakagawa T,Terao M,Shinzaki S,Yamane-Ohnuki N,Satoh M,Mehta AS,Block TM,Miyoshi E

更新日期：2011-07-01 00:00:00

abstract：:Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown o...

journal_title：International journal of oncology

authors： Sang Y,Sun L,Wu Y,Yuan W,Liu Y,Li SW

更新日期：2019-03-01 00:00:00

abstract：:Human mammary and thyroid tumors as well as peripheral blood cells of the same patients were examined for the amplification of oncogene fins and the expression of its product. Of the 7 mammary tumors analyzed, amplification of fms was observed in 6 (86%) mammary tumor DNAs, while no amplification was seen in 5 thyroid...

journal_title：International journal of oncology

authors： Haga S,Imai S,Morimoto J,Okumoto M,Nishikawa R,Mori N,Kiyozuka Y,Nagano K,Nishino T,Yamamoto H,Sarkar N

更新日期：1994-10-01 00:00:00

abstract：:Medulloblastoma is the most common malignant brain tumor in childhood. The most prevalent chromosomal abnormalities are isochromosome 17q and loss of 17p, the location of the tumor suppressor gene p53. Mutations in the p53 gene in medulloblastoma are relatively infrequent but have recently been correlated to poor prog...

journal_title：International journal of oncology

authors： Philipova T,Baryawno N,Hartmann W,Pietsch T,Druid H,Johnsen JI,Ekström TJ

更新日期：2011-03-01 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II)/IGF2R signaling plays a pivotal role in cell growth, migration and differentiation in many malignancies. An individual with high IGF-II expression levels has a high risk of developing cancer, but IGF2R is often considered to be a tumor suppressor. To date, little has been reporte...

journal_title：International journal of oncology

authors： Ou JM,Lian WS,Qiu MK,Dai YX,Dong Q,Shen J,Dong P,Wang XF,Liu YB,Quan ZW,Fei ZW

更新日期：2014-09-01 00:00:00

abstract：:miRNA‑223 (miR‑223) has been reported to function not only as a tumor suppressor, but also as an oncogenic microRNA (miRNA or miR) in various cancer cells. Therefore, the functional role of miR‑223 has not been elucidated to date, at least to the best of our knowledge. We previously performed the deep sequencing analy...

journal_title：International journal of oncology

authors： Sugita S,Yoshino H,Yonemori M,Miyamoto K,Matsushita R,Sakaguchi T,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2019-06-01 00:00:00

abstract：:The aim of this study was to demonstrate the potential of electrogene therapy with the bacterial purine nucleoside phosphorylase gene (ePNP), on pancreatic carcinoma (PC) large tumors. The in vivo electroporation (EP) conditions and efficacy were investigated on both subcutaneous xenografts of human PC cells in immuno...

journal_title：International journal of oncology

authors： Deharvengt S,Rejiba S,Wack S,Aprahamian M,Hajri A

更新日期：2007-06-01 00:00:00