Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells.

abstract：:The representative halophyte Calystegia soldanella (L) Roem. et Schult is a perennial vine herb that grows in coastal dunes throughout South Korea as well as in other regions around the world. This plant has long been used as an edible and medicinal herb to cure rheumatic arthritis, sore throat, dropsy, and scurvy. So...

journal_title：International journal of oncology

authors： Lee JI,Kim IH,Nam TJ

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffin-embedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presen...

journal_title：International journal of oncology

authors： Duray A,Descamps G,Arafa M,Decaestecker C,Remmelink M,Sirtaine N,Ernoux-Neufcoeur P,Mutijima E,Somja J,Depuydt CE,Delvenne P,Saussez S

更新日期：2011-07-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:Inflammatory abnormalities have been implicated in the pathogenesis of various human diseases, including cancer. Interleukin-1 receptor antagonist (IL1RN) is a potent anti-inflammatory molecule that modulates the biological activity of the proinflammatory cytokine, interleukin-1. The aim of this study was to examine t...

journal_title：International journal of oncology

authors： Shiiba M,Saito K,Yamagami H,Nakashima D,Higo M,Kasamatsu A,Sakamoto Y,Ogawara K,Uzawa K,Takiguchi Y,Tanzawa H

更新日期：2015-05-01 00:00:00

abstract：:Patients with esophageal carcinoma (ESCA) have a poor prognosis and high mortality rate. Although standard therapies have had effect, there is an urgent requirement to develop novel options, as increasing drug tolerance has been identified in clinical practice. In the present study, differentially expressed genes (DEG...

journal_title：International journal of oncology

authors： Chen YT,Xie JY,Sun Q,Mo WJ

更新日期：2019-01-01 00:00:00

abstract：:TP53 gene, encoding tumor protein P53, is frequently inactivated in various types of human cancer, including colorectal, lung, and gastric cancer. Cancer cells with TP53 mutation acquire malignant potentials, such as selective growth advantage, genomic instability, resistance to apoptosis, and promotion of angiogenesi...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-07-01 00:00:00

abstract：:B7-H4 is a transmembrane protein which is a member of the B7 superfamily. It is overexpressed in various types of cancer, including gastric cancer. However, the effects of B7-H4 on the tumorigenicity of gastric cancer and the underlying mechanisms have not yet been fully explored. Thus, the aim of this study was to ex...

journal_title：International journal of oncology

authors： Zhou D,Zhou Y,Li C,Yang L

更新日期：2018-04-01 00:00:00

abstract：:SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta‑analysis based on multiple...

journal_title：International journal of oncology

authors： Liu AG,Zhong JC,Chen G,He RQ,He YQ,Ma J,Yang LH,Wu XJ,Huang JT,Li JJ,Mo WJ,Qin XG

更新日期：2020-07-01 00:00:00

abstract：:The Equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, Herba epimedium brevicornum Maxim (stem and leaves), Radix morindae officinalis (root), Fructus rosa laevigatae michx (fruit), Rubus chingii Hu (fruit), Schisandra chinensis (Turz.) Baill (fruit), Ligustrum lucidum ...

journal_title：International journal of oncology

authors： Hsieh TC,Lu X,Guo J,Xiong W,Kunicki J,Darzynkiewicz Z,Wu JM

更新日期：2002-04-01 00:00:00

abstract：:Although it is well established that ras genes contribute to tumourigenesis either through the accumulation of mutations or by aberrant expression in a wide range of human cancers, little is known regarding their involvement in human nasal polyps (NPs). In the present study, the occurrence of mutations in codons 11 an...

journal_title：International journal of oncology

authors： Zaravinos A,Bizakis J,Soufla G,Sourvinos G,Spandidos DA

更新日期：2007-11-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 ...

journal_title：International journal of oncology

authors： Liu L,Yang L,Chang H,Chen YN,Zhang F,Feng S,Peng J,Ren CC,Zhang XA

更新日期：2019-03-01 00:00:00

abstract：:Choriocarcinoma is a highly malignant trophoblastic tumor related to pregnancy that often occurs with a complete hydatidiform mole. It grows quickly and can also widely metastasize to other organs or tissues through both the venous and lymphatic systems. The transforming growth factor-β1 (TGF-β1) belongs to a growth f...

journal_title：International journal of oncology

authors： Xu Q,Tan Y,Zhang K,Li Y

更新日期：2013-10-01 00:00:00

abstract：:Nitric oxide (NO) shows tumoricidal activity. We had previously reported that NO downregulates the phosphatidylinositol-3-kinase/Akt pathway, but upregulates the MEK/ERK pathway downstream of growth factor signaling. We hypothesized that NO donor and MEK inhibitor in combination syn...

journal_title：International journal of oncology

authors： Furuhashi S,Sugita H,Takamori H,Horino K,Nakahara O,Okabe H,Miyake K,Tanaka H,Beppu T,Baba H

更新日期：2012-03-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:Dose is a critical determinant of the efficacy of chemotherapy. The dose response curve for virtually all anticancer agents is steep in both in vitro and in vivo experimental studies. However the application of the steep dose-response curve in the clinic has been troublesome for many years because of dose limiting bon...

journal_title：International journal of oncology

authors： Honkoop A,Pinedo H

更新日期：1995-04-01 00:00:00

abstract：:A major limitation of cancer chemotherapy is development of resistance. In this study, we analyzed KB-3-1 cells and adriamycin-selected multidrug resistant sublines KB-A1 and KB-A10 cells for mechanisms of resistance. KB-A10 cells are 10-fold more resistant than KB-A1 cells but have lower P-glycoprotein. Of the known ...

journal_title：International journal of oncology

authors： Villagra L,Darling A,Yassa D,Scheper R,Tritton T,Bhushan A

更新日期：1997-11-01 00:00:00

abstract：:RSK2 (90 kDa ribosomal S6 kinase) is a downstream effector of the Ras/ERK (extracellular signal-regulated kinase) signaling pathway that has major functions in cell biological activities, including regulating nuclear signaling, cell cycle progression, cell proliferation, cell growth, protein synthesis, cell migration ...

journal_title：International journal of oncology

authors： Qiu Q,Jiang J,Lin L,Cheng S,Xin D,Jiang W,Shen J,Hu Z

更新日期：2016-06-01 00:00:00

abstract：:Autoimmune diseases are the consequence of the immune system attack on the self. Autoimmunity, sometimes, is reflected through the production of autoantibodies to various self antigens leading to cellular malfunction or destruction. In the current study we employ such autoantibodies for the treatment of cancer origina...

journal_title：International journal of oncology

authors： Fishman P,Merimsky O,Shoenfeld Y

更新日期：1997-05-01 00:00:00

abstract：:Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine...

journal_title：International journal of oncology

authors： Garcia-Areas R,Libreros S,Simoes M,Castro-Silva C,Gazaniga N,Amat S,Jaczewska J,Keating P,Schilling K,Brito M,Wojcikiewicz EP,Iragavarpu-Charyulu V

更新日期：2017-11-01 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most unfavorable prognostic tumor, and immediate growth and distant metastasis are important factors associated with the poor prognosis of patients with this disease. Standard and variant isoforms of CD44 are associated with tumor growth, metastasis, and epithelial-mesenchymal tr...

journal_title：International journal of oncology

authors： Miwa T,Nagata T,Kojima H,Sekine S,Okumura T

更新日期：2017-09-01 00:00:00

abstract：:An overview of the current mechanisms identified as associated with the expression of multidrug resistance is provided. The clinical relevance of multidrug resistance associated with the overexpression of the three major drug resistance-associated proteins namely, P-glycoprotein, MRP and/or LRP, is discussed. Alternat...

journal_title：International journal of oncology

authors： Hill B

更新日期：1996-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...

journal_title：International journal of oncology

authors： Collet N,Théoleyre S,Rageul J,Mottier S,Jouan F,Rioux-Leclercq N,Fergelot P,Patard JJ,Masson D,Denis MG

更新日期：2011-03-01 00:00:00

abstract：:Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR pathway inhibitors on human neuroblastoma cell survival were studied in vitro. We have recently shown on IMR-32, CHP‑134, and LA-N-1 neuroblastoma cells that targeting GD2 with the mAb decr...

journal_title：International journal of oncology

authors： Durbas M,Horwacik I,Boratyn E,Kamycka E,Rokita H

更新日期：2015-09-01 00:00:00

abstract：:We showed in our previous study that cancer upregulated gene (CUG) 2, a novel oncogene, confers resistance to infection of oncolytic vesicular stomatitis virus (VSV) by activating Stat1-mediated signal transduction. Since many studies have reported that autophagy is involved in virus replication, we investigated wheth...

journal_title：International journal of oncology

authors： Malilas W,Koh SS,Lee S,Srisuttee R,Cho IR,Moon J,Kaowinn S,Johnston RN,Chung YH

更新日期：2014-04-01 00:00:00

abstract：:Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...

journal_title：International journal of oncology

authors： Markaverich B,Alejandro M

更新日期：1997-12-01 00:00:00

abstract：:Specific RE protein species modulated by autocrine TGF alpha are unknown. HCT116 cells transfected with TGF alpha antisense expression vector were compared with control HCT116 NEO for mitogenesis and modulation of high MW (130, 120 kD) and low MW (116, 110, 105 kD) RE species. Nutrients alone (N) induced maximal mitog...

journal_title：International journal of oncology

authors： Dobre C,Ziober B,Humphrey L,Brattain M

更新日期：1996-06-01 00:00:00

abstract：:We have examined six patients with multiple low grade, low stage superficial multifocal bladder tumors with surrounding tissues for loss of heterozygosity (LOH) and microsatellite instability at chromosome 3, totaling 76 samples. The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FH...

journal_title：International journal of oncology

authors： Louhelainen J,Wijkström H,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:Previous studies have revealed that protein kinase C (PKC) is responsible for malignant progression. In the present study, we investigated the potent inhibitory effects of an antiestrogen, toremifene, on PKC-mediated cellular adhesion. A phorbol ester, phorbol 12-myristate 13-acetate (PMA), significantly enhanced alph...

journal_title：International journal of oncology

authors： Maemura M,Iino Y,Horiguchi J,Takei H,Horii Y,Koibuchi Y,Yokoe T,Takeyoshi I,Ohwada S,Morishita Y

更新日期：1998-11-01 00:00:00