Drug resistance.

abstract：:Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 20...

journal_title：International journal of oncology

authors： Mattern J,Koomagi R,Volm M

更新日期：1995-05-01 00:00:00

abstract：:The representative halophyte Calystegia soldanella (L) Roem. et Schult is a perennial vine herb that grows in coastal dunes throughout South Korea as well as in other regions around the world. This plant has long been used as an edible and medicinal herb to cure rheumatic arthritis, sore throat, dropsy, and scurvy. So...

journal_title：International journal of oncology

authors： Lee JI,Kim IH,Nam TJ

更新日期：2017-02-01 00:00:00

abstract：:We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tum...

journal_title：International journal of oncology

authors： Shimose S,Sugita T,Nitta Y,Kubo T,Ikuta Y,Murakami T

更新日期：2001-09-01 00:00:00

abstract：:Cowden's disease (CD) is an autosomal dominant disorder which confers a high susceptibility to diverse benign and malignant tumors. The PTEN (phosphatase and tensin homologue deleted in chromosome ten) gene has been identified as a tumor suppressor gene responsible for cancers of the endometrium, ovary, prostate, and ...

journal_title：International journal of oncology

authors： Kato N,Kimura K,Sugawara H,Aoyagi S,Ikeda T,Horii A

更新日期：2001-05-01 00:00:00

abstract：:Although neural and mesenchymal stem cells have been well-known to have a strong glioma tropism, this activity in induced pluripotent stem cells (iPSCs) has not yet been fully studied. In the present study, we tested tumor tropic activity of mouse iPSCs and neural stem cells derived from the iPSC (iPS-NSCs) using in v...

journal_title：International journal of oncology

authors： Yamazoe T,Koizumi S,Yamasaki T,Amano S,Tokuyama T,Namba H

更新日期：2015-01-01 00:00:00

abstract：:Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...

journal_title：International journal of oncology

authors： Choi EO,Park C,Hwang HJ,Hong SH,Kim GY,Cho EJ,Kim WJ,Choi YH

更新日期：2016-09-01 00:00:00

abstract：:Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymi...

journal_title：International journal of oncology

authors： Nishioka K,Fujimori Y,Hashimoto-Tamaoki T,Kai S,Qiu H,Kobayashi N,Tanaka N,Westerman KA,Leboulch P,Hara H

更新日期：2003-10-01 00:00:00

abstract：:Although Bmi1 is well established as one of the most commonly activated oncogenes, the precise role of Bmi1 during hepatocarcinogenesis remains unclear. In addition, Bmi1 provides a potential therapeutic target for the future treatment of hepatocellular carcinoma (HCC). In this stud...

journal_title：International journal of oncology

authors： Ruan ZP,Xu R,Lv Y,Tian T,Wang WJ,Guo H,Nan KJ

更新日期：2013-01-01 00:00:00

abstract：:177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...

journal_title：International journal of oncology

authors： Lundsten S,Spiegelberg D,Stenerlöw B,Nestor M

更新日期：2019-12-01 00:00:00

abstract：:In a recent study, we evaluated the efficacy and toxicity of 5-fluorouracil (5-FU), cisplatin (CDDP), and 5-FU plus CDDP (FP treatment) in gastric cancer cell lines and examined the relationship between the response to FP treatment and apoptosis. Our study indicated that there may be prognostic value in measuring p53 ...

journal_title：International journal of oncology

authors： Matsuhashi N,Saio M,Matsuo A,Sugiyama Y,Saji S

更新日期：2005-06-01 00:00:00

abstract：:Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear matrix proteins during HMBA-induced differentiation of human...

journal_title：International journal of oncology

authors： Xu DH,Liu F,Li X,Chen XF,Jing GJ,Wu FY,Shi SL,Li QF

更新日期：2014-07-01 00:00:00

abstract：:Polypyrimidine tract-binding protein 1 (PTBP1), a heterogeneous nuclear ribonucleoprotein, is a multi-functional RNA-binding protein. PTBP1 participates in a number of biological processes, including maintaining cell structure and motility, immunity, protein metabolism and the cell cycle. The present study aimed to in...

journal_title：International journal of oncology

authors： Shan H,Hou P,Zhang M,Li L,Pan Y,Chen F,Jiang T,Bai J,Zheng J

更新日期：2018-05-01 00:00:00

abstract：:The aim of this study was to examine the level and basic characteristics of cell‑derived microparticles (MPs) in the cyst fluids of odontogenic keratocysts (OKCs). For this purpose, MPs from the cyst fluids (CFMPs) of OKCs were purified by a classic differential centrifugation method and characterized by a transmissio...

journal_title：International journal of oncology

authors： Man QW,Zhong WQ,Ren JG,Liu JY,Zheng YY,Li RF,Nyimi BF,Chen G,Zhao YF,Liu B

更新日期：2018-06-01 00:00:00

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:Normal human diploid cells have a limited life span and undergo replicative senescence after various limited population doublings. Cells must pass the senescence barrier to become immortal. The exact mechanisms of immortalization are not clear, although inactivation of the RB pathway, and/or the p53 pathway and activa...

journal_title：International journal of oncology

authors： Liu L,Zhang J,Bates S,Li JJ,Peehl DM,Rhim JS,Pfeifer GP

更新日期：2005-01-01 00:00:00

abstract：:Primary hyperparathyroidism is a common endocrine disease with a multifaceted genetic background, the elucidation of which has only begun. Among others, loss of the short arm of chromosome 1 and somatic inactivation of the multiple endocrine neoplasia type 1 gene (MEN1) in 11q13 represent significant alterations in th...

journal_title：International journal of oncology

authors： Välimäki S,Forsberg L,Farnebo LO,Larsson C

更新日期：2002-10-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), are characterized by mutations of the KIT or platelet-derived growth factor receptor-α gene and the constitutive expression of Kit, which is currently being studied as a potential therapeutic target. In this study, we addressed the question of whether the microRNA (miRNA) 221/2...

journal_title：International journal of oncology

authors： Koelz M,Lense J,Wrba F,Scheffler M,Dienes HP,Odenthal M

更新日期：2011-02-01 00:00:00

abstract：:Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

journal_title：International journal of oncology

authors： Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

更新日期：2007-02-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade is a critical component in the regulation of cell survival and proliferation decisions. In breast carcinoma cells, activation of the p38-MAPK member of this family occurs in response to pro-inflammatory cytokines and cellular stress. The involvement of p38-MAPK in th...

journal_title：International journal of oncology

authors： Weldon CB,Parker AP,Patten D,Elliott S,Tang Y,Frigo DE,Dugan CM,Coakley EL,Butler NN,Clayton JL,Alam J,Curiel TJ,Beckman BS,Jaffe BM,Burow ME

更新日期：2004-06-01 00:00:00

abstract：:Seventy French high-risk families were screened for germ-line BRCA-1 mutations. The BRCA-1 coding region and the exon-intron boundaries were sequenced, except when pre-screening by PTT revealed a truncated protein in exon 11. Germ-line BRCA-1 mutations were detected in 24% of families. The number of breast and ovarian...

journal_title：International journal of oncology

authors： Laplace-Marieze V,Presneau N,Sylvain V,Kwiatkowski F,Lortholary A,Hardouin A,Bignon YJ

更新日期：1999-05-01 00:00:00

abstract：:In the study of 69 matched pairs of lung tumors and normal lung parenchyma, the median activities of cathepsin B (CB) and cystein proteinase inhibitors (CPI's) in tumors were found to be increased 4.4-fold and twofold, respectively. The levels of CB and CPI activities did not correlate with TNM stages nor with cell di...

journal_title：International journal of oncology

authors： Knoch H,Werle B,Ebert W,Spiess E

更新日期：1994-07-01 00:00:00

abstract：:Women from ethnic minority groups, including immigrants and refugees are reported to have low breast cancer (BC) screening rates. Active, culturally-sensitive outreach is vital for increasing participation of these women in BC screening programs. Women at high BC risk and who belong to an ethnic minority group are of ...

journal_title：International journal of oncology

authors： Belkić K,Cohen M,Wilczek B,Andersson S,Berman AH,Márquez M,Vukojević V,Mints M

更新日期：2015-09-01 00:00:00

abstract：:ATP-dependent transport of doxorubicin (DOX) by recombinant human RLIP76 has been demonstrated previously in reconstituted proteoliposomes. In the preceding communication, we demonstrated that the ATPase activity of RLIP76 was 2-fold higher in NSCLC as compared with SCLC, and it correlated with their inherent DOX resi...

journal_title：International journal of oncology

authors： Awasthi S,Singhal SS,Singhal J,Cheng J,Zimniak P,Awasthi YC

更新日期：2003-04-01 00:00:00

abstract：:Pleomorphic adenomas (PAs) of salivary glands are characterized by the mixed appearance of epithelial and mesenchymal-like components such as myxoid and chondroid tissues. Although various studies have examined PAs, thus far it is not clear how PAs make these multiple components. Thus, clarification of the histodiffer...

journal_title：International journal of oncology

authors： Kitagawa M,Ogawa I,Shima K,Hashimoto S,Kudo Y,Miyauchi M,Tahara H,Shimono M,Takata T

更新日期：2007-08-01 00:00:00

abstract：:Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown o...

journal_title：International journal of oncology

authors： Sang Y,Sun L,Wu Y,Yuan W,Liu Y,Li SW

更新日期：2019-03-01 00:00:00

abstract：:Neuroblastoma is the second most common extracranial malignant solid tumor that occurs in childhood, and metastasis is one of the major causes of death in neuroblastoma patients. The epithelial-mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. T...

journal_title：International journal of oncology

authors： Shao JB,Gao ZM,Huang WY,Lu ZB

更新日期：2017-05-01 00:00:00

abstract：:Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...

journal_title：International journal of oncology

authors： Fritz G,Issinger OG,Olsen BB

更新日期：2009-11-01 00:00:00

abstract：:Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorub...

journal_title：International journal of oncology

authors： Mattern J,Volm M

更新日期：1992-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a key role in events related to tumor cell invasion and growth. Therefore, we examined tumor tissue samples from 12 individuals with invasive breast cancer for the expression and localization of MMP-1, -2, -3 and -9. These were detected by immunohistochemistry. Simultaneously in t...

journal_title：International journal of oncology

authors： Bachmeier BE,Rohrbach H,De Waal J,Jochum M,Nerlich AG

更新日期：2005-05-01 00:00:00