Abstract:
:Although neural and mesenchymal stem cells have been well-known to have a strong glioma tropism, this activity in induced pluripotent stem cells (iPSCs) has not yet been fully studied. In the present study, we tested tumor tropic activity of mouse iPSCs and neural stem cells derived from the iPSC (iPS-NSCs) using in vitro Matrigel invasion chamber assay and in vivo mouse intracranial tumor model. Both iPSC and iPS-NSC had a similar potent in vitro tropism for glioma conditioned media. The migrated iPSCs to the gliomas kept expressing Nanog-GFP gene, suggesting no neuronal or glial differentiation. iPSCs or iPS-NSCs labeled with 5-bromo-2-deoxyuridine were intracranially implanted in the contralateral hemisphere to the GL261 glioma cell implantation in the allogeneic C57BL/6 mouse. Active migration of both stem cells was observed 7 days after implantation. Again, the iPSCs located in the tumor area expressed Nanog-GFP gene, suggesting that the migrated cells were still iPSCs. These findings demonstrated that both iPSCs and iPS-NSCs had potent glioma tropism and could be candidates as vehicles in stem cell-based glioma therapy.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Yamazoe T,Koizumi S,Yamasaki T,Amano S,Tokuyama T,Namba Hdoi
10.3892/ijo.2014.2702subject
Has Abstractpub_date
2015-01-01 00:00:00pages
147-52issue
1eissn
1019-6439issn
1791-2423journal_volume
46pub_type
杂志文章abstract::Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non‑synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterat...
journal_title:International journal of oncology
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abstract::CA IX is a tumor-associated transmembrane isoform of the carbonic anhydrase with a high enzyme activity and a functional involvement in the pH regulation and cell adhesion. Expression of CA9 gene in tumor cells is principally regulated by the high cell density and the hypoxia-related VHL-HIF pathway. In renal cell car...
journal_title:International journal of oncology
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abstract::Three major, fast developing lines of research are elucidating the biology of the mammary gland and its malignant transformation: phenotypical analyses of epithelial cells and mammary proliferative lesions, the identification, purification and characterization of mammary stem cells and breast cancer-initiating cells, ...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
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abstract::Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...
journal_title:International journal of oncology
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更新日期:2003-09-01 00:00:00
abstract::Spontaneous tumor regression is still one of the most puzzling events in human cancer. A cell culture model of malignant transformation designed to permit the study of this phenomenon in vitro was applied to examine reversion and re-expression of the transformed phenotype in two X-ray transformed mouse 10T1/2 cell clo...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:10.3892/ijo.16.3.561
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pub_type: 杂志文章
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journal_title:International journal of oncology
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doi:
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
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