Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines.

abstract：:The cell survival activity of human glioma cells is largely dependent on autocrine fibroblast growth factor (FGF) signaling. Caspases, a family of cysteine proteases, play an integral part in the execution phase of apoptosis. To better understand the mechanism of resistance to apoptosis in human glioma cells, we inves...

journal_title：International journal of oncology

authors： Fukushima S,Kato S,Maeda M,Shigemori M

更新日期：2008-02-01 00:00:00

abstract：:Chemotherapeutic resistance remains a critical clinical issue is responsible for treatment failure in patients with ovarian cancer. Evidence of the involvement of miRNAs in chemoresistance in ovarian cancer has been recently emerging. However, the underlying molecular links between chemoresistance and miRNAs remain la...

journal_title：International journal of oncology

authors： Xu M,Xiao J,Chen M,Yuan L,Li J,Shen H,Yao S

更新日期：2018-03-01 00:00:00

abstract：:Gicerin, an immunoglobulin superfamily protein, is expressed abundantly in the embryonic tissues and plays an important role in development through its cell adhesive activity. Interestingly, re-expression of gicerin is found in a variety of tumors. In the present study, the possible role of gicerin in the progression ...

journal_title：International journal of oncology

authors： Tsukamoto Y,Sakaiuchi T,Hiroi S,Furuya M,Tsuchiya S,Sasaki F,Miki N,Taira E

更新日期：2003-12-01 00:00:00

abstract：:Human chorionic gonadotropin (hCG) inhibits the growth of human breast epithelial cells MCF-7. Differential display was utilized for analyzing RNA of hCG-treated MCF-7 cells in order to determine whether this effect was mediated by specific gene activation or repression. Three cDNA clones, 19, 29 and 44, were differen...

journal_title：International journal of oncology

authors： Srivastava P,Silva ID,Russo J,Mgbonyebi OP,Russo IH

更新日期：1998-09-01 00:00:00

abstract：:Activation of intestinal human pregnane X receptor (PXR) has recently been proposed as a promising strategy for the chemoprevention of inflammation-induced colon cancer. The present study was aimed at evaluating the effect of rifaximin, a non-absorbable antibiotic, in inhibiting angiogenesis in a model of human colore...

journal_title：International journal of oncology

authors： Esposito G,Gigli S,Seguella L,Nobile N,D'Alessandro A,Pesce M,Capoccia E,Steardo L,Cirillo C,Cuomo R,Sarnelli G

更新日期：2016-08-01 00:00:00

abstract：:Hypoxia, a common phenomenon during the development of malignant solid tumors including breast cancer, serves to propagate a cascade of molecular pathways triggered by hypoxia-inducible factor-1α (HIF-1α). Carbonic anhydrase IX (CA IX), one of the target genes of HIF-1α, has been reported to be involved in progression...

journal_title：International journal of oncology

authors： Chu CY,Jin YT,Zhang W,Yu J,Yang HP,Wang HY,Zhang ZJ,Liu XP,Zou Q

更新日期：2016-01-01 00:00:00

abstract：:Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...

journal_title：International journal of oncology

authors： Zhang MH,Hu YD,Xu Y,Xiao Y,Luo Y,Song ZC,Zhou J

更新日期：2013-04-01 00:00:00

abstract：:A long-held central dogma of radiation biology has been that the carcinogenic effects of ionizing radiation (IR) are induced by the direct and radiolytic actions of IR on nuclear DNA. Numerous investigations, however, have revealed that several cancer relevant effects of IR can occur in cells that have received only c...

journal_title：International journal of oncology

authors： Goldberg Z,Lehnert BE

更新日期：2002-08-01 00:00:00

abstract：:This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...

journal_title：International journal of oncology

authors： Van den Neste E,Cardoen S,Offner F,Bontemps F

更新日期：2005-10-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of lysyl oxidase‑like 2 (LOXL2) on the invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of renal cell carcinoma (RCC) cells through the steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway. RCC tissues and adjacen...

journal_title：International journal of oncology

authors： Hong X,Yu JJ

更新日期：2019-05-01 00:00:00

abstract：:Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...

journal_title：International journal of oncology

authors： Isayeva T,Kumar S,Ponnazhagan S

更新日期：2004-08-01 00:00:00

abstract：:This study evaluated the effects of a combination of opioid growth factor (OGF) and paclitaxel on squamous cell carcinoma of the head and neck (SCCHN) using a tissue culture model of human SCCHN. The combination of OGF and paclitaxel was markedly inhibitory to SCCHN proliferation, reducing growth from control levels b...

journal_title：International journal of oncology

authors： McLaughlin PJ,Jaglowski JR,Verderame MF,Stack BC,Leure-Dupree AE,Zagon IS

更新日期：2005-03-01 00:00:00

abstract：:The present study shows that an application of cyclophosphamide (CY) supported by dendritic cell (DC)-based vaccines affected differentiation of the activity of CD4+ T cell subpopulations accompanied by an alteration in CD8+ cell number. Vaccines were composed of bone marrow-derived DCs activated with tumor cell lysat...

journal_title：International journal of oncology

authors： Wojas-Turek J,Szczygieł A,Kicielińska J,Rossowska J,Piasecki E,Pajtasz-Piasecka E

更新日期：2016-02-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis of all malignancies, and current therapeutic options do not target cancer stem cells (CSCs), which may be the reason for the extreme aggressiveness. The dietary agents sulforaphane and quercetin enriched e.g., in broccoli, and the main and best studied gre...

journal_title：International journal of oncology

authors： Appari M,Babu KR,Kaczorowski A,Gross W,Herr I

更新日期：2014-10-01 00:00:00

abstract：:The biological factors responsible for the increased aggressiveness in atypical meningiomas are not well known. The aim of this study is to evaluate the discriminatory value of a number of biological markers (S100 proteins and galectin-3 and its ligand profile) with respect to benign and atypical meningiomas. Using 63...

journal_title：International journal of oncology

authors： Hancq S,Salmon I,Brotchi J,Gabius HJ,Heizmann CW,Kiss R,Decaestecker C

更新日期：2004-11-01 00:00:00

abstract：:Although most hepatocellular carcinoma (HCC) is related to viral infection, there is a substantial population of HCC patients (5-20%) who are negative for both markers of hepatitis B virus and hepatitis C virus infection [non-B, non-C (NBNC) hepatitis] in Japan and the incidence of NBNC-HCC has recently tended to incr...

journal_title：International journal of oncology

authors： Nishikawa H,Osaki Y

更新日期：2013-11-01 00:00:00

abstract：:Gliomas are malignant brain tumors thought to arise through multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cyclin D1 gene encodes a proto-oncogenic cell cycle regulator implicated in the pathogenesis of several types of cancer, including gliomas. Northe...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-09-01 00:00:00

abstract：:Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...

journal_title：International journal of oncology

authors： Kondo R,Ishino K,Wada R,Takata H,Peng WX,Kudo M,Kure S,Kaneya Y,Taniai N,Yoshida H,Naito Z

更新日期：2019-04-01 00:00:00

abstract：:Orlistat is an orally administered anti-obesity drug that has shown significant antitumor activity in a variety of tumor cells. To identify the proteins involved in its antitumor activity, we employed a proteomic approach to reveal protein expression changes in the human ovarian can...

journal_title：International journal of oncology

authors： Huang HQ,Tang J,Zhou ST,Yi T,Peng HL,Shen GB,Xie N,Huang K,Yang T,Wu JH,Huang CH,Wei YQ,Zhao X

更新日期：2012-08-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. However, the effects of SAL on metastatic capacity of HT1080 human fibrosarcoma cells have not been elucidated. We investigated the effect of SAL on migration an...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2016-06-01 00:00:00

abstract：:The promising benefits of cancer gene therapy have been limited by the inability to deliver therapeutic genes homogeneously throughout the tumor mass and to control gene expression within the tumor cells. Transcriptional targeting, the use of DNA regulatory promoter sequences to localize transgene expression, has been...

journal_title：International journal of oncology

authors： Lopez CA,Park JO,Mauceri HJ,Beckett MA,Weichselbaum RR,Posner MC

更新日期：2004-03-01 00:00:00

abstract：:To evaluate the significance of microsatellite instability (MI) and loss of heterozygosity (LOH) in the development of different histological subgroups of liposarcomas, we examined 28 tissue-samples from 21 patients and the corresponding non-neoplastic reference tissues. We investigated nine microsatellite loci and de...

journal_title：International journal of oncology

authors： Schneider-Stock R,Szibor R,Walter H,Plate I,Roessner A

更新日期：1999-04-01 00:00:00

abstract：:The poor prognosis of Ewing's sarcoma (EWS), together with its high lethal recurrence rate and the side‑effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side‑effects. The oncogenic chimeric protein EWS/FLI1 is the key malignancy driver in mo...

journal_title：International journal of oncology

authors： Sengupta A,Rahman M,Mateo-Lozano S,Tirado OM,Notario V

更新日期：2013-09-01 00:00:00

abstract：:Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against brea...

journal_title：International journal of oncology

authors： Echiburú-Chau C,Alfaro-Lira S,Brown N,Salas CO,Cuellar M,Santander J,Ogalde JP,Rothhammer F

更新日期：2014-04-01 00:00:00

abstract：:Following the publication of this article, the authors noted that there was an error in the affiliations. Specifically, the affiliation of the first author JUAN XU should be: Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China. [the original article was publis...

journal_title：International journal of oncology

authors： Xu J,Jiang N,Shi H,Zhao S,Yao S,Shen H

更新日期：2017-06-01 00:00:00

abstract：:Acquirement of multi-drug resistance by tumor cells represents a major obstacle in the management of prostate cancer. Such resistance was demonstrated in the androgen-independent DU-145 cells in response to paclitaxel and the mechanisms by which these cell develops resistance was not understood. The objective of this ...

journal_title：International journal of oncology

authors： Flynn V Jr,Ramanitharan A,Moparty K,Davis R,Sikka S,Agrawal KC,Abdel-Mageed AB

更新日期：2003-08-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade, which includes MAPK, MAP kinase kinase (MAPKK) and Raf-l, is involved in the signal transduction of growth factor receptors. We found that the MAPK and Raf-l proteins are increased in human breast cancer. Activated MAPKK was also observed. We then investigated wheth...

journal_title：International journal of oncology

authors： Koibuchi Y,Iino Y,Uchida T,Nagasawa M,Morishita Y

更新日期：1997-09-01 00:00:00

abstract：:The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody ...

journal_title：International journal of oncology

authors： Ishikawa T,Furihata M,Ohtsuki Y,Ono H,Inoue A,Ogoshi S

更新日期：1997-11-01 00:00:00

abstract：:A murine B16 melanoma parental line (B16) and two clones either pigmented (B16P) or non-pigmented (B16NP) were cocultured as aggregates with mouse 3T3 fibroblasts. In vivo, these mixed aggregates developed more aggressive tumors in the mouse than corresponding pure aggregates. In vitro, the three pure cell lines secre...

journal_title：International journal of oncology

authors： Coucke P,Baramova E,Leprince P,Depauwgillet M,Foidart J,Bassleer R

更新日期：1994-11-01 00:00:00