Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis.

abstract：:Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...

journal_title：International journal of oncology

authors： Lin C,Tsai SC,Tseng MT,Peng SF,Kuo SC,Lin MW,Hsu YM,Lee MR,Amagaya S,Huang WW,Wu TS,Yang JS

更新日期：2013-03-01 00:00:00

abstract：:Quinazolinone derivatives are known to possess anticancer activities on cell metastasis and cell death in different human cancer cell lines. Here, we studied the anti-metastasis activity and the underlying mechanisms of the novel quinazoline derivative MJ-56 (6-pyrrolidinyl-2-(3-bromostyryl)quinazolin-4-one). MJ-56 in...

journal_title：International journal of oncology

authors： Chen HJ,Jiang YL,Lin CM,Tsai SC,Peng SF,Fushiya S,Hour MJ,Yang JS

更新日期：2013-07-01 00:00:00

abstract：:The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...

journal_title：International journal of oncology

authors： Chow LS,Wang X,Kwong DL,Sham JS,Tsao SW,Nicholls JM

更新日期：2000-07-01 00:00:00

abstract：:The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers. However, the function and molecular mechanisms of CXCR7 in human colorectal cancer (CRC) are still undefined. In the present study, sixty-eight cases of CRC tissues and corresponding adjac...

journal_title：International journal of oncology

authors： Li XX,Zheng HT,Huang LY,Shi DB,Peng JJ,Liang L,Cai SJ

更新日期：2014-10-01 00:00:00

abstract：:Although CD138 expression is a hallmark of plasma cells and myeloma cells, reduced CD138 expression is occasionally found. However, the mechanisms underlying CD138 downregulation in myeloma cells remain unclear. Previous reports suggest that the bone marrow microenvironment may contribute to CD138 downregulation. Amon...

journal_title：International journal of oncology

authors： Kawano Y,Kikukawa Y,Fujiwara S,Wada N,Okuno Y,Mitsuya H,Hata H

更新日期：2013-12-01 00:00:00

abstract：:Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, the antitumor mechanism of metformin in several types of cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal ...

journal_title：International journal of oncology

authors： Miyoshi H,Kato K,Iwama H,Maeda E,Sakamoto T,Fujita K,Toyota Y,Tani J,Nomura T,Mimura S,Kobayashi M,Morishita A,Kobara H,Mori H,Yoneyama H,Deguchi A,Himoto T,Kurokohchi K,Okano K,Suzuki Y,Murao K,Masaki T

更新日期：2014-07-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family and is highly expressed in several types of cancer cells and/or stromal tissue. Lumican expression in the cytoplasm in advanced colorectal cancer correlates with poor patient prognosis. The expression of lumican in stromal tissues is associated with a hig...

journal_title：International journal of oncology

authors： Matsuda Y,Yamamoto T,Kudo M,Kawahara K,Kawamoto M,Nakajima Y,Koizumi K,Nakazawa N,Ishiwata T,Naito Z

更新日期：2008-12-01 00:00:00

abstract：:Induction of the B7 family molecules by 12-O-tetradecanoyl phorbol 13-acetate (TPA) has been reported, however, the mechanism by which TPA up-regulates these molecules remains poorly understood. In this study, the expression of B7-DC, -H1, -H2, and -H3 in response to TPA was markedly induced in K562 cells. TPA also in...

journal_title：International journal of oncology

authors： Jang BC,Park YK,Choi IH,Kim SP,Hwang JB,Baek WK,Suh MH,Mun KC,Suh SI

更新日期：2007-12-01 00:00:00

abstract：:Metal-containing compounds have been extensively studied for many years as potent proteasome inhibitors. The 20S proteasome, the main component of the ubiquitin proteasome pathway, is one of the excellent targets in anticancer drug development. We recently reported that several copper complexes were able to inhibit ca...

journal_title：International journal of oncology

authors： Zhang Z,Wang H,Wang Q,Yan M,Wang H,Bi C,Sun S,Fan Y

更新日期：2016-08-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...

journal_title：International journal of oncology

authors： Hossain MA,Kim DH,Jang JY,Kang YJ,Yoon JH,Moon JO,Chung HY,Kim GY,Choi YH,Copple BL,Kim ND

更新日期：2012-04-01 00:00:00

abstract：:Activation of intestinal human pregnane X receptor (PXR) has recently been proposed as a promising strategy for the chemoprevention of inflammation-induced colon cancer. The present study was aimed at evaluating the effect of rifaximin, a non-absorbable antibiotic, in inhibiting angiogenesis in a model of human colore...

journal_title：International journal of oncology

authors： Esposito G,Gigli S,Seguella L,Nobile N,D'Alessandro A,Pesce M,Capoccia E,Steardo L,Cirillo C,Cuomo R,Sarnelli G

更新日期：2016-08-01 00:00:00

abstract：:According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...

journal_title：International journal of oncology

authors： Furihata M,Sonobe H,Ohtsuki Y

更新日期：1995-06-01 00:00:00

abstract：:We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...

journal_title：International journal of oncology

authors： Doucrasy S,Coll J,Barrois M,Joubel A,Prost S,Dozier C,Stehelin D,Riou G

更新日期：1993-05-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological cancer. We identified interleukin 11 (IL11) as a critical mediator of endometrial tumourigenesis and demonstrated that IL11 regulates chondroitin sulfate proteoglycan (CSPG4) in human placental trophoblasts. CSPG4 is a cell membrane protein overexpressed in numerous ...

journal_title：International journal of oncology

authors： Winship A,Van Sinderen M,Heffernan-Marks A,Dimitriadis E

更新日期：2017-03-01 00:00:00

abstract：:Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...

journal_title：International journal of oncology

authors： Narayanan R,Kim HN,Narayanan NK,Nargi D,Narayanan B

更新日期：2012-01-01 00:00:00

abstract：:Neuroblastoma (NB) is one of the most common extracranial solid tumors in children, which has complex molecular mechanisms. Increasing evidence has suggested that long noncoding RNAs (lncRNAs) account for NB pathogenesis. However, the function of small nucleolar RNA host gene 16 (SNHG16) in NB is currently unclear. In...

journal_title：International journal of oncology

authors： Yu Y,Chen F,Yang Y,Jin Y,Shi J,Han S,Chu P,Lu J,Tai J,Wang S,Yang W,Wang H,Guo Y,Ni X

更新日期：2019-07-01 00:00:00

abstract：:The aim was to compare the efficacy of ondansetron and a combination of ondansetron plus dexamethasone in the prophylaxis of cisplatin-induced delayed emesis over three consecutive courses of chemotherapy. Cancer patients scheduled to receive for the first time cisplatin (>50 mg/m(2)) in combination with other cytotox...

journal_title：International journal of oncology

authors： Gridelli C,Ianniello G,Ambrosini G,Mustacchi G,Pedicini T,Farris A,Iacobelli S,Rossi G,Moretti G,Angelini F,Delena M,Dicarlo A,Bonsignori M,Sabbatini R,Catalano G,Rossi A,Olivieri A,Fina P,Bianco A

更新日期：1997-02-01 00:00:00

abstract：:Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...

journal_title：International journal of oncology

authors： Rieger C,Huebner D,Temme A,Wirth MP,Fuessel S

更新日期：2015-09-01 00:00:00

abstract：:Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFkappaB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFkappaB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly in...

journal_title：International journal of oncology

authors： Huang C,Chen N,Ma WY,Dong Z

更新日期：1998-10-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：International journal of oncology

authors： Navolanic PM,McCubrey JA

更新日期：2005-11-01 00:00:00

abstract：:Ovarian cancer is a lethal malignancy, rarely diagnosed early, and there is currently little, if any, preventive strategies which can be followed. This study attempts to identify lifestyle profiles which might be associated with ovarian cancer, and could then be subject to subsequent modification in an effort to preve...

journal_title：International journal of oncology

authors： Loesch M,Fischer M,Shurpin K,Mann W

更新日期：1994-03-01 00:00:00

abstract：:Liquid crystals are the state of matter existing between liquid and crystalline phases, and recently there has been increasing interest in their biological effects. Following our recently reported work, we investigated the cell suppressive effects of liquid crystal-related compounds (LCRCs), which are precursors of li...

journal_title：International journal of oncology

authors： Wakasaya T,Yoshino H,Fukushi Y,Yoshizawa A,Kashiwakura I

更新日期：2013-04-01 00:00:00

abstract：:The long-term survival for elderly patients with advanced ovarian papillary serous carcinoma (OPSC) does not exceed 30%, and the incidence and prognosis rise continuously after menopause. The aim of this study was to identify the differences in key miRNAs and their potential regulators through miRNA microarray analysi...

journal_title：International journal of oncology

authors： Zhao H,Ding Y,Tie B,Sun ZF,Jiang JY,Zhao J,Lin X,Cui S

更新日期：2013-09-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00

abstract：:To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...

journal_title：International journal of oncology

authors： Kohnoe S,Maehara Y,Takahashi I,Yoshida M,Emi Y,Baba H,Sugimachi K

更新日期：1993-11-01 00:00:00

abstract：:Cytogenetic analyses of peripheral blood cells of breast cancer patients unveiled in one case a grossly enlarged G-band in one copy of chromosome 16 (16qh+), which scored also strongly positive in C-banding. Fluorescence in situ hybridization with both a total chromosome 16 library and with probe pHuR195 detecting loc...

journal_title：International journal of oncology

authors： Savelyeva L,Schneider B,Finke L,Schlag P,Schwab M

更新日期：1994-02-01 00:00:00

abstract：:Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous ad...

journal_title：International journal of oncology

authors： Tsukagoshi S,Saga Y,Suzuki N,Fujioka A,Nakagawa F,Fukushima M,Suzuki M

更新日期：2003-05-01 00:00:00

abstract：:Advanced metastatic melanoma is a malignant tumor for which there is currently no effective treatment due to resistance development. Ginsenoside Rg3, a saponin component extracted from ginseng roots, has been shown to reduce melanoma cell proliferation by decreasing histone deacetylase 3 and increasing p53 acetylation...

journal_title：International journal of oncology

authors： Meng L,Ji R,Dong X,Xu X,Xin Y,Jiang X

更新日期：2019-06-01 00:00:00

abstract：:Glioma is the most prevalent and fatal primary tumor of the central nervous system in adults, while the development of effective therapeutic strategies in clinical practice remain a challenge. Nucleotide-binding domain leucine-rich family pyrin-containing 3 (NLRP3) has been reported to be associated with tumorigenesis...

journal_title：International journal of oncology

authors： Yin XF,Zhang Q,Chen ZY,Wang HF,Li X,Wang HX,Li HX,Kang CM,Chu S,Li KF,Li Y,Qiu YR

更新日期：2018-09-01 00:00:00

abstract：:Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...

journal_title：International journal of oncology

authors： Patel MR,Sadiq AA,Jay-Dixon J,Jirakulaporn T,Jacobson BA,Farassati F,Bitterman PB,Kratzke RA

更新日期：2012-02-01 00:00:00