12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells.

abstract：:Induction of differentiation in a variety of model systems is accompanied by cell cycle exit and inhibition of Cdk2 kinase activity. We asked whether inhibition of Cdk2 activity is sufficient to allow differentiation to occur in a non-small cell lung cancer cell line. Treatment of NCI-H358 with flavopiridol, an inhibi...

journal_title：International journal of oncology

authors： Lee HR,Chang TH,Tebalt MJ 3rd,Senderowicz AM,Szabo E

更新日期：1999-07-01 00:00:00

abstract：:Two mouse HPV16-transformed cell lines, viz. MK16 cells, which induce metastasizing tumors, and TC-1 cells, which induce non-metastasizing tumors were transduced with the gene for mouse endostatin. Two clones constitutively expressing endostatin were isolated from each of them. They were denoted ME3 and ME9, and TE2 a...

journal_title：International journal of oncology

authors： Lakatosova-Andelova M,Duskova M,Lucansky V,Paral P,Vonka V

更新日期：2009-07-01 00:00:00

abstract：:Lipomas are the most common soft tissue tumors in adults. They often carry chromosome aberrations involving 12q13~15 leading to rearrangements of the HMGA2 gene in 12q14.3, with breakpoints occurring within or outside of the gene. Here, we present eleven lipomas and one osteochondrolipoma with a novel recurrent chromo...

journal_title：International journal of oncology

authors： Panagopoulos I,Gorunova L,Bjerkehagen B,Lobmaier I,Heim S

更新日期：2015-09-01 00:00:00

abstract：:Hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC) is a global health problem that accounts for more than half of total liver cancer cases in developing countries. Despite the growing number of researches conducted, the molecular mechanism underlying the development of HCC remains elusive. Long non‑coding ...

journal_title：International journal of oncology

authors： Zhang H,Chen X,Zhang J,Wang X,Chen H,Liu L,Liu S

更新日期：2020-01-01 00:00:00

abstract：:Percutaneous nephrostomy (PN) will rapidly correct renal failure due to ureteral obstruction. Complications of the procedure are few and the procedure can be quickly accomplished on an outpatient basis using local anesthesia. A retrospective review of fifty patients who underwent PN led to derivation of a formula whic...

journal_title：International journal of oncology

authors： McKenna B,Chalas E,Ferretti J,Rothpearl A,Mann W

更新日期：1994-04-01 00:00:00

abstract：:The regions upstream from the human N-myc gene were examined for both transcription and replication. The plasmids containing several N-myc regions linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to human neuroblastoma IMR32 cells. The results indicated that the region spanning fro...

journal_title：International journal of oncology

authors： Nakagawa T,Imamura Y,Iguchiariga S,Ariga H

更新日期：1994-09-01 00:00:00

abstract：:Gene therapy is a newly hatched field of biomedical research aimed at introducing therapeutically important genes into somatic cells of patients for the treatment of human disease. Whereas for inborn errors of metabolism transfer of a single gene can correct the disorder, cancer is a complex disease involving mutation...

journal_title：International journal of oncology

authors： Boulikas T

更新日期：1996-11-01 00:00:00

abstract：:Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The re...

journal_title：International journal of oncology

authors： Zhang Y,Ying X,Han S,Wang J,Zhou X,Bai E,Zhang J,Zhu Q

更新日期：2013-01-01 00:00:00

abstract：:Lymph node metastasis of breast cancer is a clinical marker of poor prognosis. Yet, there exist no therapies targeting mechanisms of intravasation into lymphatics. Herein we report on an effect of the antidyslipidemic drug fenofibrate with vasoprotective activity, which attenuates breast cancer intravasation in vitro,...

journal_title：International journal of oncology

authors： Nguyen CH,Huttary N,Atanasov AG,Chatuphonprasert W,Brenner S,Fristiohady A,Hong J,Stadler S,Holzner S,Milovanovic D,Dirsch VM,Kopp B,Saiko P,Krenn L,Jäger W,Krupitza G

更新日期：2017-05-01 00:00:00

abstract：:The tumor suppressor gene product p53 has been detected in a high percentage of esophageal squamous cell carcinoma. To evaluate the role of this protein in carcinogenesis, we examined the p53 overexpression both in esophageal dysplasia and in esophageal squamous cell carcinoma in the same patients. Using anti-p53 anti...

journal_title：International journal of oncology

authors： Maruyama K,Shiozaki H,Shimaya K,Inoue M,Iwazawa T,Matsui S,Mori T

更新日期：1994-05-01 00:00:00

abstract：:Early-onset breast cancer is one of the most common malignancies and causes of death among young women, and its incidence is increasing. In the present study, we aimed to investigate the epigenetic modifications of the breast cancer type 1 susceptibility gene (BRCA1) in breast tissues and blood cells derived from wome...

journal_title：International journal of oncology

authors： Al-Moghrabi N,Al-Qasem AJ,Aboussekhra A

更新日期：2011-07-01 00:00:00

abstract：:Accumulating evidence has demonstrated the crucial roles of long non‑coding RNAs (lncRNAs) in various human cancers, including non‑small cell lung cancer (NSCLC). However, to the best of our knowledge, the role of the lncRNA cancer susceptibility candidate 7 (CASC7) in NSCLC has not been clearly determined. The aim of...

journal_title：International journal of oncology

authors： Chen L,Li X,Lu C,Zhao Y,Zhu J,Yang L

更新日期：2020-08-01 00:00:00

abstract：:By setting the cut-off line at the level as used in a negative control study without primary antibody in the same sample, the Ki-67 labeling rate was calculated by the Ki67-DNA dual fluorescence analysis. The mean Ki-67 labeling rate of 28 advanced gastric cancer was 45.1% (13.9-76.3%). The Ki-67 labeling rates were s...

journal_title：International journal of oncology

authors： Kimura H,Yonemura Y,Miyazaki I

更新日期：1992-08-01 00:00:00

abstract：:Oncogenic, moderately immunogenic MK16/1/IIIABC (MK16) cells were previously established by co-transfection of HPV 16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of the MK16 cells produced progressively growing neoplasms which metastasized spontaneously to lungs. In t...

journal_title：International journal of oncology

authors： Mendoza L,Bubeník J,Símová J,Jandlová T,Vonka V,Mikysková R

更新日期：2003-07-01 00:00:00

abstract：:Human pancreatic ductal adenocarcinomas overexpress the epidermal growth factor (EGF) receptor. Betacellulin is a mitogenic polypeptide that binds and activates this receptor. To determine whether betacellulin has a role in human pancreatic cancer, we studied its expression in cultured human pancreatic cancer cell lin...

journal_title：International journal of oncology

authors： Yokoyama M,Funatomi H,Kobrin M,Ebert M,Friess H,Buchler M,Korc M

更新日期：1995-10-01 00:00:00

abstract：:Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ...

journal_title：International journal of oncology

authors： Li Z,Sun L,Lu Z,Su X,Yang Q,Qu X,Li L,Song K,Kong B

更新日期：2015-09-01 00:00:00

abstract：:Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...

journal_title：International journal of oncology

authors： Pereira MC,de Bessa-Garcia SA,Burikhanov R,Pavanelli AC,Antunes L,Rangnekar VM,Nagai MA

更新日期：2013-08-01 00:00:00

abstract：:The gp160 human kidney differentiation antigen is identical to human aminopeptidase A (APA), a zinc-dependent cell-surface metallopeptidase which hydrolyzes peptides with N-terminal acidic residues. GP160/APA is constitutively expressed by proximal tubule cells, the normal cellular counterpart of most renal cancers (R...

journal_title：International journal of oncology

authors： Nanus DM,Bogenrieder T,Papandreou CN,Finstad CL,Lee A,Vlamis V,Motzer RJ,Bander NH,Albino AP,Reuter VE

更新日期：1998-08-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:Extracellular matrix breakdown as well as increased expression in cancer cells and tumor microvascular endothelial cells make matrix metalloproteinase 2 (MMP2) an attractive target for cancer treatment. By taking advantage of MMP2's properties, an MMP2 cleavable melittin/avidin conjugate was designed. Melittin alone i...

journal_title：International journal of oncology

authors： Holle L,Song W,Holle E,Wei Y,Wagner T,Yu X

更新日期：2003-01-01 00:00:00

abstract：:This study evaluated the effects of a combination of opioid growth factor (OGF) and paclitaxel on squamous cell carcinoma of the head and neck (SCCHN) using a tissue culture model of human SCCHN. The combination of OGF and paclitaxel was markedly inhibitory to SCCHN proliferation, reducing growth from control levels b...

journal_title：International journal of oncology

authors： McLaughlin PJ,Jaglowski JR,Verderame MF,Stack BC,Leure-Dupree AE,Zagon IS

更新日期：2005-03-01 00:00:00

abstract：:The proper structure of the extracellular matrix, in particular of the basement membrane and the adjacent interstitial matrix, are essential prerequisites for a proper function of tissues. Invasive growth in malignant tumors is associated with a destruction of various matrix structures. Due to extensive recent analyse...

journal_title：International journal of oncology

authors： Hagedorn HG,Bachmeier BE,Nerlich AG

更新日期：2001-04-01 00:00:00

abstract：:Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients wi...

journal_title：International journal of oncology

authors： Wu C,Habib N,Mitry R,Reitsma P,Vandeventer S,Chamuleau R

更新日期：1997-07-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:p73 has been shown to transcriptionally activate genes positively responsive to wild-type p53. In order to undertake a comparative study of functions of p53 and p73 we have cloned the cDNA of p73 from MCF-7 cells. Adenovirus onco-protein E1A inhibits the transactivation by p73; a deletion mutant of E1A incapable of in...

journal_title：International journal of oncology

authors： Deb D,Lanyi A,Scian M,Keiger J,Brown DR,Le Roith D,Deb SP,Deb S

更新日期：2001-02-01 00:00:00

abstract：:Metastatic disease commonly occurs in the spine and incidence is likely to increase secondary to improved survival rates in many cancer patients. Despite published research on instability in patients with metastatic disease of the thoracolumbar spine, controversy exists regarding risk factors for instability and indic...

journal_title：International journal of oncology

authors： Weber MH,Burch S,Buckley J,Schmidt MH,Fehlings MG,Vrionis FD,Fisher CG

更新日期：2011-01-01 00:00:00

abstract：:Cervical lymph node metastasis is the most common recurrence pattern of head and neck squamous cell carcinoma (HNSCC), and it is usually treated with radiation therapy and/or neck dissection. There has long been a desire for markers useful in predicting radiosensitivity to enable assignment of patients with recurrent ...

journal_title：International journal of oncology

authors： Ito Y,Kamijo T,Yokose T,Kawashima M,Ogino T,Ikeda H,Hayashi R,Sasaki S,Ochiai A

更新日期：2001-12-01 00:00:00

abstract：:Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a s...

journal_title：International journal of oncology

authors： Choi YM,An S,Lee EM,Kim K,Choi SJ,Kim JS,Jang HH,An IS,Bae S

更新日期：2012-07-01 00:00:00

abstract：:Lack of life-prolonging therapies has provided much of the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, the use of dietary supplements and botanical products has been showing a sustained increase in recent years, owing in part to some en...

journal_title：International journal of oncology

authors： Lu X,Hsieh TC,Wu JM

更新日期：2004-12-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00