Abstract:
:We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expression greatly varied among the different types of cancer and within the same type of cancer. For example, the 2.3 kb BAC transcript band was detected in 94% of breast adenocarcinomas and in only 35% of epidermoid lung carcinomas with differences of 100-fold in the level of expression between tumor specimens. The majority of tumor tissues displayed BAC expression while their normal counterpart did not with the exception of normal breast tissues which contained low but significant level of BAC transcript. It is possible that BAC expression was influenced by the presence of gene deletions in tumors. Indeed, this gene is located in chromosome 11p15, a region in which deletions have frequently been observed in human cancers. Therefore, the variable levels of expression could have a biological significance and be used as a marker of tumor progression.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Doucrasy S,Coll J,Barrois M,Joubel A,Prost S,Dozier C,Stehelin D,Riou Gdoi
10.3892/ijo.2.5.753subject
Has Abstractpub_date
1993-05-01 00:00:00pages
753-8issue
5eissn
1019-6439issn
1791-2423journal_volume
2pub_type
杂志文章abstract::The mitogen-activated protein kinase (MAPK) cascade, which includes MAPK, MAP kinase kinase (MAPKK) and Raf-l, is involved in the signal transduction of growth factor receptors. We found that the MAPK and Raf-l proteins are increased in human breast cancer. Activated MAPKK was also observed. We then investigated wheth...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.3.583
更新日期:1997-09-01 00:00:00
abstract::To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::We have reported that ONO-4007, a novel synthetic lipid A derivative with low toxic activities, produced large amount of tumor necrosis factor (TNF)-alpha selectively in the tumor tissues and brought about complete cures in about 60% of rats bearing TNF-alpha sensitive KDH-8 cells, which also secreted a large amount o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::Human chondrosarcoma cells (HCS-TG) were transduced with the gene for a herpes simplex virus thymidine kinase (HSV-tk) or Escherichia coli beta-galactosidase (lacZ). We investigated the cytotoxicity of human chondrosarcoma bearing an HSV-tk gene after treatment with ganciclovir. Chondrosarcoma cells bearing an HSV-tk ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.6.1137
更新日期:1999-06-01 00:00:00
abstract::Three major, fast developing lines of research are elucidating the biology of the mammary gland and its malignant transformation: phenotypical analyses of epithelial cells and mammary proliferative lesions, the identification, purification and characterization of mammary stem cells and breast cancer-initiating cells, ...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-01 00:00:00
abstract::We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha). High incidence of lymphoma development in this transgenic mouse model system was similar to lymphoma development in p53 knockout mice. In an effort to understand the molecular basis of lymphomagenesis...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.16.3.561
更新日期:2000-03-01 00:00:00
abstract::Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can als...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.18.4.825
更新日期:2001-04-01 00:00:00
abstract::The transcription factor E2F4 plays a critical role in cell cycle progression of normal and cancerous intestinal epithelial cells. Contrary to other E2Fs, the coding region of the E2F4 gene contains a longer spacer segment of a CAG trinucleotide repeat sequence encoding 13 consecutive serine residues, which is highly ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2131
更新日期:2013-12-01 00:00:00
abstract::Previous studies have revealed that protein kinase C (PKC) is responsible for malignant progression. In the present study, we investigated the potent inhibitory effects of an antiestrogen, toremifene, on PKC-mediated cellular adhesion. A phorbol ester, phorbol 12-myristate 13-acetate (PMA), significantly enhanced alph...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.5.981
更新日期:1998-11-01 00:00:00
abstract::Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.9.6.1295
更新日期:1996-12-01 00:00:00
abstract::Chemo- and radiotherapy induce apoptosis in tumours and surrounding tissues. In a search for robust and reliable apoptosis markers, we have evaluated immunostaining patterns of gammaH2AX and cleaved PARP-1 in paraffin-embedded cellular spheroids. Breast cancer BT474 cells were grown as cell spheroids to diameters of 7...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000311
更新日期:2009-07-01 00:00:00
abstract::According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.6.1209
更新日期:1995-06-01 00:00:00
abstract::A major limitation of cancer chemotherapy is development of resistance. In this study, we analyzed KB-3-1 cells and adriamycin-selected multidrug resistant sublines KB-A1 and KB-A10 cells for mechanisms of resistance. KB-A10 cells are 10-fold more resistant than KB-A1 cells but have lower P-glycoprotein. Of the known ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.5.1025
更新日期:1997-11-01 00:00:00
abstract::A promising family of anticancer agents, the camptothecins, is noted for their ability to induce apoptosis specifically in malignant cells. However, a major obstacle for successful cancer treatment by these and other chemotherapeutic agents is the intrinsic or acquired resistance to drug treatment. Resistance to 9NC6,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Insulin-like growth factor-II (IGF-II)/IGF2R signaling plays a pivotal role in cell growth, migration and differentiation in many malignancies. An individual with high IGF-II expression levels has a high risk of developing cancer, but IGF2R is often considered to be a tumor suppressor. To date, little has been reporte...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2512
更新日期:2014-09-01 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2010.891
更新日期:2011-03-01 00:00:00
abstract::The deregulation of the epidermal growth factor receptor (EGFR) pathway plays a major role in the pathogenesis of prostate cancer (PCa). However, therapies targeting EGFR have demonstrated limited effectiveness in PCa. A potential mechanism to overcome EGFR blockade in cancer cells is the autocrine activation of alter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1509
更新日期:2012-09-01 00:00:00
abstract::MicroRNAs (miRNAs) were reported to be involved in the development of clear cell renal cell carcinoma (ccRCC). However, the study on miRNAs in ccRCC is far from complete. The present study identified miRNAs which could act as potential novel prognostic markers for ccRCC, and analyzed its possible mechanism. We found t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3746
更新日期:2016-12-01 00:00:00
abstract::Phosphorylation of histone H2AX (gammaH2AX) is a sensitive marker of DNA damage, particularly induction of DNA double-strand breaks. Using multiparameter cytometry we explored the effects of doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types of endometrioid adenocarcinoma cell lines (HEC-1A, H...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000589
更新日期:2010-05-01 00:00:00
abstract::Observational, clinical and experimental studies have suggested that dietary supplementation with selenium can inhibit the development of colon cancer. Since toxicity and chemopreventive efficacy of selenium compounds depend to a large extent, on the form of selenium the development of efficacious organoselenium compo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.1.29
更新日期:1998-07-01 00:00:00
abstract::Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2256
更新日期:2014-03-01 00:00:00
abstract::Several lines of direct evidence show that gliomas express high levels of vascular endothelial growth factor (VEGF). VEGF can promote the growth of gliomas through angiogenesis. It is believed that gliomas originate in the brain tumor stem cells (BTSCs). However, the direct effect of VEGF on the biological behavior of...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2331
更新日期:2014-05-01 00:00:00
abstract::To evaluate the significance of microsatellite instability (MI) and loss of heterozygosity (LOH) in the development of different histological subgroups of liposarcomas, we examined 28 tissue-samples from 21 patients and the corresponding non-neoplastic reference tissues. We investigated nine microsatellite loci and de...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.4.721
更新日期:1999-04-01 00:00:00
abstract::IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3750
更新日期:2016-12-01 00:00:00
abstract::The development of colorectal cancer (CRC) is strongly correlated with the aberrant activation of multiple intracellular signaling transduction cascades including STAT3, ERK, JNK and p38 pathways which usually function redundantly. In addition, crosstalk between these pathways forms a complicated signaling network tha...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2040
更新日期:2013-10-01 00:00:00
abstract::An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1719
更新日期:2013-02-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3566
更新日期:2016-08-01 00:00:00
abstract::The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy. Eight human glioma cell lines and twelve primary human glioma cell cultures were...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, dr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1483
更新日期:2012-08-01 00:00:00
abstract::Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1105
更新日期:2011-10-01 00:00:00