Abstract:
:According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p53 gene expression has exceptionally been implicated in the development of a wide variety of human cancers and it is generally accepted that p53 is a component in biochemical pathways central to human carcinogenesis. Although the role of the p53 gene in cancer genesis and development has fueled as many questions, study of p53 has come to the forefront of cancer research and detection of its abnormalities during the development of tumors may have diagnostic, prognostic and therapeutic implications. To be of value in clinical practice, immunohistochemical assessment of p53 protein should provide clinically relevant information. The degree of concordance between p53 gene mutation and the accumulation of p53 protein cannot be perfect, however, the immunohistochemical assay using anti-p53 antibodies is the most widely applicable approach for detection of tumors in routine investigations, particularly with regard to diagnosis or prognosis.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Furihata M,Sonobe H,Ohtsuki Ydoi
10.3892/ijo.6.6.1209subject
Has Abstractpub_date
1995-06-01 00:00:00pages
1209-26issue
6eissn
1019-6439issn
1791-2423journal_volume
6pub_type
杂志文章abstract::Human breast cancer is a major cause of global morbidity and mortality in women and it is a process that involves numerous molecular and cellular alterations attributed to environmental substances and agents such as hormones. Bisphosphonates, such as pamidronate, are potent antiresorptive drugs used to the treatment o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2955
更新日期:2015-01-01 00:00:00
abstract::The mitogen-activated protein kinase (MAPK) cascade, which includes MAPK, MAP kinase kinase (MAPKK) and Raf-l, is involved in the signal transduction of growth factor receptors. We found that the MAPK and Raf-l proteins are increased in human breast cancer. Activated MAPKK was also observed. We then investigated wheth...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.3.583
更新日期:1997-09-01 00:00:00
abstract::Tanshinone IIA (TSIIA), a natural diterpene quinone in the traditional Chinese medicinal herb Dan-Shen (Salvia miltiorrhiza), has extensively exerted antitumor activity in cellular and animal models. However, the molecular mechanisms underlying the antitumor effects of TSIIA remain largely unknown. The in vitro effect...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2471
更新日期:2014-08-01 00:00:00
abstract::Integrin alpha 6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin alpha 6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.5.959
更新日期:1997-11-01 00:00:00
abstract::MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2707
更新日期:2015-01-01 00:00:00
abstract::We describe and discuss the findings by fluorescent in situ hybridization (FISH) for detection of non-random chromosomal gains, in a group of unusual fibrous lesions in children. Nuclear disaggregation was used to prepare slides from eight cases which were hybridized using alpha-satellite enumeration probes for chromo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.3.433
更新日期:2000-09-01 00:00:00
abstract::In contrast to normal cells, cancer cells typically undergo metabolic reprogramming. Studies have shown that oncogenes play an important role in this metabolic reprogramming. CD38 is a multifunctional transmembrane protein that is expressed abnormally in a variety of tumor types. To investigate the effect and possible...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5040
更新日期:2020-07-01 00:00:00
abstract::Whilst the role of microRNA‑143 (miR‑143) in myelodysplastic syndrome (MDS) remains unclear, abnormally expressed microRNA‑143 has been detected in many types of cancer tissues. In this study, we describe a cohort study for the verification of miR‑143 expression, as well as the investigation of the molecular mechanism...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4534
更新日期:2018-11-01 00:00:00
abstract::To evaluate the significance of microsatellite instability (MI) and loss of heterozygosity (LOH) in the development of different histological subgroups of liposarcomas, we examined 28 tissue-samples from 21 patients and the corresponding non-neoplastic reference tissues. We investigated nine microsatellite loci and de...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.4.721
更新日期:1999-04-01 00:00:00
abstract::Thymidylate synthase (TS) is an essential enzyme for DNA biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-FU), which is frequently used against human colon adenocarcinomas. Because levels of TS in such tumors may be predictive of chemotherapeutic response to 5-FU...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::A chromosomal break indicates a double-stranded DNA break of the chromatin fiber. Cytogenetic observations can enumerate chromosome breaks but cannot detect single-stranded DNA breaks (nicks). When a high frequency of chromosomal breaks occurs in a cell population, whether spontaneously occurred or mutagen induced, a ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.6.873
更新日期:1993-06-01 00:00:00
abstract::The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1457
更新日期:2012-07-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3566
更新日期:2016-08-01 00:00:00
abstract::Ligands of the EGF/Heregulin family control the growth of epithelial cells by binding to receptors of the erbB family. By searching a large database of cDNA sequences at Human Genome Sciences Inc. we have identified a new encoded protein sequence containing all the conserved elements of the EGF/Heregulin family. The s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.5.1061
更新日期:1998-11-01 00:00:00
abstract::The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1139
更新日期:2011-11-01 00:00:00
abstract::A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the eff...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.15.4.835
更新日期:1999-10-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with broad resistance to chemotherapeutic drugs. Krüppel-like factor 4 (KLF4) is a candidate tumor suppressor in PDAC. However, the precise role of KLF4 in gemcitabine resistance of PDAC remains largely unclear. In this study, we demonstrat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4099
更新日期:2017-10-01 00:00:00
abstract::We review our recent experience with intensity-modulated radiation therapy (IMRT) and conventional three-dimensional radiation therapy (C3DRT) in advanced head and neck cancer. Sixty-nine patients with Stage IV head and neck cancer (and stage III base of tongue and hypopharynx) enrolled in a Phase II study of definiti...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.5.951
更新日期:1996-05-01 00:00:00
abstract::Lymph node metastasis of breast cancer is a clinical marker of poor prognosis. Yet, there exist no therapies targeting mechanisms of intravasation into lymphatics. Herein we report on an effect of the antidyslipidemic drug fenofibrate with vasoprotective activity, which attenuates breast cancer intravasation in vitro,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.3956
更新日期:2017-05-01 00:00:00
abstract::Inositol hexaphosphate (IP6), also known as phytic acid, has been shown to exhibit anticancer effects in a number of preclinical tumor models. IP6 decreases proliferation by arresting cells in the G0/G1 phase, inhibits iron-mediated oxidative reactions, enhances differentiation and stimulates apoptosis. The present st...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4488
更新日期:2018-10-01 00:00:00
abstract::Collagen type I is an abundant component of the extracellular matrix and due to its longevity, constitutes a prominent target of non-enzymatic post-translational in vivo modifications such as carbamylation and glycation. These protein modifications involved in aging, renal diseases and diabetes, are linked to elevated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1393
更新日期:2012-06-01 00:00:00
abstract::Hepatocellular carcinoma is the most frequent liver cancer and hepatitis B virus is included among the risk factors for the development of this type of neoplasia. Direct detection of this virus is difficult due to the lack of a simple tissue culture system for growing the virus. Amplification of HBV nucleic acid seque...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::The MyD118/Gadd45/CR6 gene family (also termed Gadd45beta/alpha/gamma) has been identified as genes which are rapidly induced by genotoxic agents, during terminal differentiation, as well as by apoptotic cytokines. In recent years, evidence has emerged that the proteins encoded by these genes play pivotal roles in neg...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.9.1.49
更新日期:1996-07-01 00:00:00
abstract::CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4303
更新日期:2018-05-01 00:00:00
abstract::Previously, we found that the injection of zoledronic acid (ZOL) into mice bearing tumor induced changes of the vascular structure in the tumor. In this study, we examined whether ZOL treatment could decrease interstitial fluid pressure (IFP) via change of tumor vasculature, and enhance the antitumor efficacy of lipos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2991
更新日期:2015-07-01 00:00:00
abstract::5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity induced by 5-FU alon...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2904
更新日期:2015-05-01 00:00:00
abstract::Gastric carcinoma may occur sporadically or in association with hereditary diseases, such as Peutz-Jehgers syndrome (PJS). The PJS gene (named STK11 or LKB1) was mapped to 19p13.3 and recently cloned. Germ-line mutations of the gene have been detected in familial PJS patients and are predicted to predispose STK11 carr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00