Abstract:
:We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 cell lines were resistant or low sensitive to anti-Fas induced apoptosis. In addition, cancer cells in all of the RCC tissues and all cell lines expressed an anti-apoptotic proto-oncogene, bcl-2 product. In conclusion, i) Fas/Fas-ligand system may be often impaired in RCCs despite their frequent expression; and ii) their frequent Bcl-2 expression may further contribute to the resistance to various apoptotic stimuli.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Inoue M,Yano H,Kojiro Mdoi
10.3892/ijo.9.1.49subject
Has Abstractpub_date
1996-07-01 00:00:00pages
49-56issue
1eissn
1019-6439issn
1791-2423journal_volume
9pub_type
杂志文章abstract::In a recent study, we evaluated the efficacy and toxicity of 5-fluorouracil (5-FU), cisplatin (CDDP), and 5-FU plus CDDP (FP treatment) in gastric cancer cell lines and examined the relationship between the response to FP treatment and apoptosis. Our study indicated that there may be prognostic value in measuring p53 ...
journal_title:International journal of oncology
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abstract::The cell-adhesion properties of cancer cells can be targeted to block cancer metastasis. Although cytosolic lysyl-tRNA synthetase (KRS) functions in protein synthesis, KRS on the plasma membrane is involved in cancer metastasis. We hypothesized that KRS is involved in cell adhesion-related signal transduction for cell...
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
abstract::We examined the relationships among nuclear DNA content, tumor origin, nuclear size, and prognosis in squamous cell lung cancer. Central tumors had significantly higher DNA aneuploidy (83%, p<0.01) and DNA indices (1.65+/-0.40, p<0.01) than did peripheral tumors (40%, 1.29+/-0.37, respectively). All six women in the s...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:1996-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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