Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma.

abstract：:Dose is a critical determinant of the efficacy of chemotherapy. The dose response curve for virtually all anticancer agents is steep in both in vitro and in vivo experimental studies. However the application of the steep dose-response curve in the clinic has been troublesome for many years because of dose limiting bon...

journal_title：International journal of oncology

authors： Honkoop A,Pinedo H

更新日期：1995-04-01 00:00:00

abstract：:The gp160 human kidney differentiation antigen is identical to human aminopeptidase A (APA), a zinc-dependent cell-surface metallopeptidase which hydrolyzes peptides with N-terminal acidic residues. GP160/APA is constitutively expressed by proximal tubule cells, the normal cellular counterpart of most renal cancers (R...

journal_title：International journal of oncology

authors： Nanus DM,Bogenrieder T,Papandreou CN,Finstad CL,Lee A,Vlamis V,Motzer RJ,Bander NH,Albino AP,Reuter VE

更新日期：1998-08-01 00:00:00

abstract：:Previously we have demonstrated that the tumor infiltrating lymphocytes found in SJL/J mice with reticulum cell sarcomas (RCS) are CD4+ T cells which express T cell receptor (TCR) beta chain molecules comprised principally of Vbeta17a encoded variable gene segments. Herein we report both the cellular and molecular cha...

journal_title：International journal of oncology

authors： Katz J,Bonavida B

更新日期：1994-04-01 00:00:00

abstract：:Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...

journal_title：International journal of oncology

authors： Kijima H,Yamazaki H,Nakamura M,Scanlon KJ,Osamura RY,Ueyama Y

更新日期：2004-03-01 00:00:00

abstract：:Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...

journal_title：International journal of oncology

authors： Nozaki Y,Isobe K,Nakashima I,Shimokata K

更新日期：1993-06-01 00:00:00

abstract：:Neoadjuvant chemotherapy with docetaxel for advanced breast cancer can improve the radicality for a subset of patients, but some patients suffer from severe adverse drug reactions without any benefit. To establish a method for predicting responses to docetaxel, we analyzed gene expression profiles of biopsy materials ...

journal_title：International journal of oncology

authors： Zembutsu H,Suzuki Y,Sasaki A,Tsunoda T,Okazaki M,Yoshimoto M,Hasegawa T,Hirata K,Nakamura Y

更新日期：2009-02-01 00:00:00

abstract：:A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...

journal_title：International journal of oncology

authors： Tillotson J,Darzynkiewicz Z,Cohen L,Ronai Z

更新日期：1993-07-01 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...

journal_title：International journal of oncology

authors： Koizumi K,Alonso S,Miyaki Y,Okada S,Ogura H,Shiiya N,Konishi F,Taya T,Perucho M,Suzuki K

更新日期：2012-04-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:Chemotherapeutic resistance remains a critical clinical issue is responsible for treatment failure in patients with ovarian cancer. Evidence of the involvement of miRNAs in chemoresistance in ovarian cancer has been recently emerging. However, the underlying molecular links between chemoresistance and miRNAs remain la...

journal_title：International journal of oncology

authors： Xu M,Xiao J,Chen M,Yuan L,Li J,Shen H,Yao S

更新日期：2018-03-01 00:00:00

abstract：:Meningiomas are benign brain tumors thought to arise by multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cell cycle regulator proto-oncogene cyclin D1 has been implicated in the pathogenesis of several types of cancer. Northern blot analysis revealed expr...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-12-01 00:00:00

abstract：:Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFkappaB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFkappaB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly in...

journal_title：International journal of oncology

authors： Huang C,Chen N,Ma WY,Dong Z

更新日期：1998-10-01 00:00:00

abstract：:Normal human diploid cells have a limited life span and undergo replicative senescence after various limited population doublings. Cells must pass the senescence barrier to become immortal. The exact mechanisms of immortalization are not clear, although inactivation of the RB pathway, and/or the p53 pathway and activa...

journal_title：International journal of oncology

authors： Liu L,Zhang J,Bates S,Li JJ,Peehl DM,Rhim JS,Pfeifer GP

更新日期：2005-01-01 00:00:00

abstract：:Telomeres, repeated DNA sequences (T2AG3)n that guard the ends of chromosomes, serve as a checkpoint for cell-cycle progression and regulate cell senescence and apoptosis. Loss of the telomeric repeats promotes genomic instability, which is the hallmark of most cancer cells. Whether this loss differs among tumor cells...

journal_title：International journal of oncology

authors： Multani AS,Ozen M,Sen S,Mandal AK,Price JE,Fan D,Radinsky R,Ali-Osman F,Von Eschenbach AC,Fidler IJ,Pathak S

更新日期：1999-09-01 00:00:00

abstract：:Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...

journal_title：International journal of oncology

authors： Ciatto S,Cataliotti L,Pacini P,Distante V,Bianchi S,Simoncini R,Cardona G,Rontini M,Falli F,Elbetti C

更新日期：1993-08-01 00:00:00

abstract：:Resistance to first-line chemotherapeutic drugs such as gemcitabine contributes to the poor prognosis of patients with pancreatic cancer. MicroRNAs (miRNA) regulate chemoresistance in pancreatic cancer. By analyzing the miRNA sequencing dataset of pancreatic cancer from The Cancer Genome Atlas, it was demonstrated tha...

journal_title：International journal of oncology

authors： Sun D,Wang X,Sui G,Chen S,Yu M,Zhang P

更新日期：2018-05-01 00:00:00

abstract：:The potential of arsenic trioxide (As2O3) as a novel therapy against ovarian cancer has been progressively recognized. Its prospective usefulness for treatment of this malignancy either alone or in combination with other chemotherapeutic agents has been increasingly explored. In this study, we attempted to enhance the...

journal_title：International journal of oncology

authors： Ong PS,Chan SY,Ho PC

更新日期：2011-06-01 00:00:00

abstract：:CDC28 protein kinase regulatory subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have investigated its involvement in gastric cancer. In this study, we focused on the clinical and biological significance of CKS2 over-expression in gastric...

journal_title：International journal of oncology

authors： Tanaka F,Matsuzaki S,Mimori K,Kita Y,Inoue H,Mori M

更新日期：2011-08-01 00:00:00

abstract：:The epidermal growth factor (EGF) receptor (EGFR) is activated by EGF and other EGF-like growth factors, including amphiregulin (AR). We characterized the localization and mitogenic action of AR in T3M4 and COLO-357 human pancreatic cancer cell lines and determined whether the presence of AR in human pancreatic cancer...

journal_title：International journal of oncology

authors： Yokoyama M,Ebert M,Funatomi H,Friess H,Buchler M,Johnson G,Korc M

更新日期：1995-03-01 00:00:00

abstract：:RhKGF is developed for prevention and treatment of chemotherapy- and radiation-induced epithelial damage in cancer patients. Little information exists on growth modulation of malignant cells by KGF. We have tested the anchorage-independent clonal growth of 35 human tumor and 22 lymphoma and leukemia cell lines in semi...

journal_title：International journal of oncology

authors： Oelmann E,Haghgu S,Kulimova E,Mesters RM,Kienast J,Herbst H,Schmitmann C,Kolkmeyer A,Serve H,Berdel WE

更新日期：2004-10-01 00:00:00

abstract：:Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...

journal_title：International journal of oncology

authors： Williams J,Maitland N,Mott M,Brown K

更新日期：1992-12-01 00:00:00

abstract：:miRNA‑223 (miR‑223) has been reported to function not only as a tumor suppressor, but also as an oncogenic microRNA (miRNA or miR) in various cancer cells. Therefore, the functional role of miR‑223 has not been elucidated to date, at least to the best of our knowledge. We previously performed the deep sequencing analy...

journal_title：International journal of oncology

authors： Sugita S,Yoshino H,Yonemori M,Miyamoto K,Matsushita R,Sakaguchi T,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2019-06-01 00:00:00

abstract：:The impacts of post‑operative abdominal infectious complications increase hematogenous distant metastasis and result in poor long‑term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is a...

journal_title：International journal of oncology

authors： Okazaki M,Yamaguchi T,Tajima H,Fushida S,Ohta T

更新日期：2020-10-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00

abstract：:Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...

journal_title：International journal of oncology

authors： Yang JY,Xia W,Hu MC

更新日期：2006-09-01 00:00:00

abstract：:Total body irradiation (TBI), given in low to moderate doses as a single modality, can enhance leukocyte populations and immune modifiers, resulting in slowed tumor progression. The aim of this study was to evaluate natural killer (NK) cell involvement in mediating the antitumor effect of TBI by depleting NK populatio...

journal_title：International journal of oncology

authors： Miller GM,Andres ML,Gridley DS

更新日期：2003-12-01 00:00:00

abstract：:Human papillomavirus 16 (HPV-16) is strongly associated with the development of 50% of cervical cancers. The E6 and E7 proteins encoded by high-risk HPV types are associated with the immune evasion of cervical cancer cells, but the mechanism is poorly understood. The purpose of this study was to investigate whether ce...

journal_title：International journal of oncology

authors： Gao LJ,Gu PQ,Fan WM,Liu Z,Qiu F,Peng YZ,Guo XR

更新日期：2011-11-01 00:00:00

abstract：:CA IX is a tumor-associated transmembrane isoform of the carbonic anhydrase with a high enzyme activity and a functional involvement in the pH regulation and cell adhesion. Expression of CA9 gene in tumor cells is principally regulated by the high cell density and the hypoxia-related VHL-HIF pathway. In renal cell car...

journal_title：International journal of oncology

authors： Jakubicková L,Biesová Z,Pastoreková S,Kettmann R,Pastorek J

更新日期：2005-04-01 00:00:00

abstract：:Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and p...

journal_title：International journal of oncology

authors： Haneji T,Hirashima K,Teramachi J,Morimoto H

更新日期：2013-06-01 00:00:00

abstract：:In the present study, a series of seven synthetic croma-kalim analogues were prepared and evaluated for cytotoxic effect on human cervical carcinoma HeLa cells using WST-8 assay. A preliminary screening of these cromakalim analogues showed that 1-[(3S,4R)-4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy- 2,2-dimethylchr...

journal_title：International journal of oncology

authors： Zhang X,Zhao J,Kang S,Yi M,You S,Shin DS,Kim DK

更新日期：2011-12-01 00:00:00